Krakus Mound, a pre-historic man-made hill in Krakow, provides a magnificent panorama of the city. The opposite direction opens up to a gravel pit named Kamieniołom Libana. Here, a Jewish entrepreneur, Bernard Liban, founded a company for the production of limestone and fertilizers in 1873. Later on, the plant was used as a Nazi labor camp. At the place where this camp was situated, the American fKrakus Mound, a pre-historic man-made hill in Krakow, provides a magnificent panorama of the city. The opposite direction opens up to a gravel pit named Kamieniołom Libana. Here, a Jewish entrepreneur, Bernard Liban, founded a company for the production of limestone and fertilizers in 1873. Later on, the plant was used as a Nazi labor camp. At the place where this camp was situated, the American f

The association between human leukocyte antigen (HLA) insulin-dependent diabetes was studied in a large population-based investigation using genotyping of 425 new-onset patients, 0-14 years of age, and 367 matched control subjects. As many as 97% of patients compared with 75% of control subjects were positive for one or several of DQA1*0301, DQA1*0501, DQB1*0302, or DQB1*0201. Asp-57 DQB was prese

During the preclinical period of insulin-dependent diabetes mellitus (IDDM), progression to clinical IDDM is characterized by declining β-cell function. Although the presence of insulin autoantibodies (IAA) improves the ability of islet cell antibodies (ICA) to predict subsequent clinical IDDM, few studies have examined the risk of developing IDDM in subjects positive for IAA but negative for both

Galectins are a family of galactoside-recognizing proteins involved in different galectin-subtype-specific inflammatory and tumor-promoting processes, which motivates the development of inhibitors that are more selective galectin inhibitors than natural ligand fragments. Here, we describe the synthesis and evaluation of 3-C-methyl-gulopyranoside derivatives and their evaluation as galectin inhibit

This article presents two learning processes in order to explain how children at an early age can transform a complex sensory input to concepts and categories. The first process constructs the perceptual structures that emerge in children’s cognitive development by detecting invariants in the sensory input. The invariant structures involve a reduction in dimensionality of the sensory information.

Theories of taste-based discrimination predict that competitive pressures will drive discriminatory behavior out of the market. The authors analyze how firm takeovers and product market competition affect firms' gender composition and gender wage gap using detailed matched employer-employee data. Taking into account several endogeneity concerns while using a difference-in-difference framework, the

Liver disease is linked to a decreased capacity of hepatocytes to divide. In addition, cellular metabolism is important for tissue homeostasis and regeneration. Since metabolic changes are a hallmark of liver disease, we investigated the connections between metabolism and cell division. We determined global metabolic changes at different stages of liver regeneration using a combination of integrat

Global profiling of protein expression through the cell cycle has revealed subsets of periodically expressed proteins. However, expression levels alone only give a partial view of the biochemical processes determining cellular events. Using a proteome-wide implementation of the cellular thermal shift assay (CETSA) to study specific cell-cycle phases, we uncover changes of interaction states for mo

The failure of pancreatic isletβ-cells is a major contributor to the etiology of type 2 diabetes.β-Cell dysfunction and declining β-cell mass are two mechanisms that contribute to this failure, although it is unclear whether they are molecularly linked. Here, we show that the cell cycle regulator, cyclin-dependent kinase 2 (CDK2), couples primary β-cell dysfunction to the progressive deterioration

Thermoresponsive structures in the 5'-untranslated region of mRNA are known to control translation of heat shock and virulence genes. Expression of many rhizobial heat shock genes is regulated by a conserved sequence element called ROSE for repression of heat shock gene expression. This cis-acting, untranslated mRNA is thought to prevent ribosome access at low temperature through an extended secon

To ensure a continuous high standard of police units, it is critical to recruit people who perform well in stressful situations. Today, this selection process includes performing a large series of tests, which still may not objectively reveal a person’s capacity to handle a life-threatening situation when subjected to high levels of stress. To obtain more systematic and objective data, 12 police o

Most autoimmune diabetes occurs in those without a diabetic relative, but few cases are identifiable prospectively. To model general population prediction, 491 consecutive newly diabetic children from all of Sweden were tested for autoantibodies to glutamate decarboxylase (GAD65ab), insulin (IAA), and islet cells (ICA), and for HLA-DQ genotypes by PCR; 415 matched control children were tested in p

The transmission of HLA-DR and DQ was compared between 46 families with at least one child affected by insulin dependent diabetes mellitis (IDDM) and 43 healthy control families. In the patient families, there was an increased transmission of DR4 (p

We report on the straightforward metal-free synthesis of poly(p-terphenyl perfluorophenylsulfonic acid)s by efficient superacid catalyzed Friedel–Crafts polycondensations of commercially available perfluoroacetophenone and p-terphenyl, followed by sulfonation of the pendant pentafluorophenyl groups via a selective and quantitative thiolation-oxidation procedure. The stiff and well-defined polymer

Delegationen för senior arbetskraft har i uppdrag att verka för ett mer inkluderande och åldersoberoende synsätt i arbetslivet. Delegationen ska sammanställa och sprida kunskap om forskning om äldres möjligheter och även föreslå åtgärder som motverkar åldersdiskriminering för att bättre tillvarata senior erfarenhet. Som en viktig del av arbetet med uppdraget har delegationen valt att ta fram en se

Introduction: Breathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m2) is rapidly increasing globally and its impact on breathlessness is unclear. Methods: This population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessnes