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Comparison of diagnostic accuracy of current left bundle branch block and ventricular pacing ECG criteria for detection of occlusion myocardial infarction

Background: Electrocardiographic detection of patients with occlusion myocardial infarction (OMI) can be difficult in patients with left bundle branch block (LBBB) or ventricular paced rhythm (VPR) and several ECG criteria for the detection of OMI in LBBB/VPR exist. Most recently, the Barcelona criteria, which includes concordant ST deviation and discordant ST deviation in leads with low R/S ampli

High-Throughput Drug Screening Revealed That Ciclopirox Olamine Can Engender Gastric Cancer Stem-like Cells

Cancer stem cells (CSCs) are relevant therapeutic targets for cancer treatment. Still, the molecular circuits behind CSC characteristics are not fully understood. The low number of CSCs can sometimes be an obstacle to carrying out assays that explore their properties. Thus, increasing CSC numbers via small molecule-mediated cellular reprogramming appears to be a valid alternative tool. Using the S

Optimization of Induction Machine Design for Electric Vehicle Powertrain

This paper proposes a methodology to include induction machine (IM) in an optimization scheme for EV powertrains using Particle Swarm Optimization (PSO) as the optimization algorithm. The IM model is developed based on finite element analysis (FEA) and all the losses are estimated. The main objective is to generate a large database of base designs in a computationally efficient but accurate way. T

Treatment outcomes of childhood PICALM::MLLT10 acute leukaemias

The prognostic impact of PICALM::MLLT10 status in childhood leukaemia is not well described. Ten International Berlin Frankfurt Münster-affiliated study groups and the Children's Oncology Group collaborated in this multicentre retrospective study. The presence of the PICALM::MLLT10 fusion gene was confirmed by fluorescence in situ hybridization and/or RNA sequencing at participating sites. Ninety-

Scoping carbon dioxide removal options for Germany–What is their potential contribution to Net-Zero CO2?

In its latest assessment report the IPCC stresses the need for carbon dioxide removal (CDR) to counterbalance residual emissions to achieve net zero carbon dioxide or greenhouse gas emissions. There are currently a wide variety of CDR measures available. Their potential and feasibility, however, depends on context specific conditions, as among others biophysical site characteristics, or availabili

Finding the dispersing siblings of young open clusters : Dynamical traceback simulations using Gaia DR3

Context. Stars tend to form in clusters, but many escape their birth clusters very early. Identifying the escaped members of clusters can inform us about the dissolution of star clusters, but also about the stellar dynamics in the galaxy. Methods capable of finding escaped stars from many clusters are required to fully exploit the large amounts of data in the Gaia era. Aims. We present a new metho

Recent patent-based review on the role of three-dimensional printing technology in pharmaceutical and biomedical applications

Three-dimensional printing (3DP) is emerging as an innovative manufacturing technology for biomedical and pharmaceutical applications, since the US FDA approval of Spritam as a 3D-printed drug. In the present review, we have highlighted the potential benefits of 3DP technology in healthcare, such as the ability to create patient-specific medical devices and implants, as well as the possibility of

Utility of heparin-binding protein following cardiothoracic surgery using cardiopulmonary bypass

Cardiothoracic surgery using cardiopulmonary bypass (CPB) triggers an inflammatory state that may be difficult to differentiate from infection. Heparin-binding protein (HBP) is a candidate biomarker for sepsis. As data indicates that HBP normalizes rapidly after cardiothoracic surgery, it may be a suitable early marker of postoperative infection. We therefore aimed to investigate which variables i

THz Spectroscopic Electron Paramagnetic Resonance of the Fe3+Defect in GaN

We present a recently developed method for electron paramagnetic resonance (EPR) measurements in the THz spectral range. The method is based on spectroscopic ellipsometry and thus requires no cavity, unlike conventional EPR. This permits us to scan the frequency parameters in addition to the magnetic field parameters. To showcase this, both frequency and magnetic field scans are performed on Fe-do

ESMO Expert Consensus Statements on the management of breast cancer during pregnancy (PrBC)

The management of breast cancer during pregnancy (PrBC) is a relatively rare indication and an area where no or little evidence is available since randomized controlled trials cannot be conducted. In general, advances related to breast cancer (BC) treatment outside pregnancy cannot always be translated to PrBC, because both the interests of the mother and of the unborn should be considered. Eviden

Numerical and experimental investigations on residual stress evolution of multiple sequential cuts in turning

Residual stress is of great importance on the fatigue life of components; nevertheless, most of the simulations of turning operation focus on the first cut and ignore the evolution of residual stress in sequential cutting. The present study aims to explore the surface residual stress profile along the feed direction during longitudinal turning, to understand the impact of sequential cuts on turnin

Decolonising pedagogy in practice : cuerpo-territorio to consolidate students´ learning

Cuerpo-territorio is a method stemming from Latin American geography, which recognizes the centrality of situated and embodied experiences as a form of knowing. We engaged with this method in the classroom to understand how students through their embodied and situated experiences had absorbed a post-development geographic course content and how these notions had remained with them. Given that emot

Seed treatment with clothianidin induces changes in plant metabolism and alters pollinator foraging preferences

Neonicotinoids, systemic insecticides that are distributed into all plant tissues and protect against pests, have become a common part of crop production, but can unintentionally also affect non-target organisms, including pollinators. Such effects can be direct effects from insecticide exposure, but neonicotinoids can affect plant physiology, and effects could therefore also be indirectly mediate

Hybrid Governance Arrangements for Urban Infrastructure Transitions : Comparing the Adoption of Onsite Water Reuse in San Francisco and New York City

Decentralized water reuse technologies are increasingly being explored as a transformative approach for complementing centralized water and wastewater infrastructure. A transition to onsite water reuse requires a better understanding of how urban infrastructures are governed. While governance tends to be discussed within ideal types─i.e., hierarchy, market, and network─researchers increasingly rec

Optimal Carrier Frequency Design for Frequency Diverse Array Mimo Radar

In this work, we introduce a novel approach for designing the transmit frequency offset scheme based on Cramér-Rao lower bound (CRLB) minimization for a frequency diverse array multiple-input multiple-output (FDA-MIMO) radar. The problem originates in non-uniform FDA radar where each frequency offset scheme derives from a specific mathematical model, but where no optimization is conducted with res

Machine Learning Models for Prediction of Diabetic Microvascular Complications

IMPORTANCE AND AIMS: Diabetic microvascular complications significantly impact morbidity and mortality. This review focuses on machine learning/artificial intelligence (ML/AI) in predicting diabetic retinopathy (DR), diabetic kidney disease (DKD), and diabetic neuropathy (DN).METHODS: A comprehensive PubMed search from 1990 to 2023 identified studies on ML/AI models for diabetic microvascular comp