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Comparison of CGRP and NO responses in the human peripheral microcirculation of migraine and control subjects.

Calcitonin gene-related peptide (CGRP) and nitric oxide (NO) are two molecules shown to have a role in migraine pathophysiology. Our objective was to test the hypothesis that migraine subjects are particularly sensitive to these signal molecules. The cutaneous microvascular responses to endothelial and non-endothelial dependent dilators were tested using laser Doppler flowmetry in combination with

Progressive resistance training after stroke: Effects on muscle strength, muscle tone, gait performance and perceived participation.

OBJECTIVE: To evaluate the effects of progressive resistance training on muscle strength, muscle tone, gait performance and perceived participation after stroke. DESIGN: A randomized controlled trial. SUBJECTS: Twenty-four subjects (mean age 61 years (standard deviation 5)) 6-48 months post-stroke. METHODS: The training group (n = 15) participated in supervised progressive resistance training of t

Speech results in adult Swedish patients born with bilateral complete cleft lip and palate.

Thirty-six adult patients (26 men and 10 women) who had been operated on for bilateral complete cleft lip and palate (BCLP) were evaluated with regard to long-term follow-up consisting of clinical investigation, perceptual speech analysis, and self-estimation of quality of speech. Twenty-six had had a von Langenbeck repair at the age of 14 months (L-14 group), and 10 a Wardill repair at the age of

Kvalitet i nya deponiers lakvatten - resultat från Renovas deponi Fläskebo

EU:s deponeringsdirektiv har medfört ökade krav på deponier. Mängden deponerat organiskt material har begränsats kraftigt och deponiernas inre skall nu vara så torrt som möjligt. Konsekvenserna av detta är ännu inte helt kända. Fläskebodeponin, den deponi som varit i drift längst av de få svenska deponier som är konstruerade enligt direktivet, har här fungerat som ett exempel på framtidens depoThe European landfill directive increases demands on landfills. The amount of organic matter being landfilled is restricted and landfills should be as dry as possible. The consequences of these changes are not yet fully understood. In this study the first landfill in Sweden to be constructed according to the directive, Fläskebo, has served as an example of future landfills. Its leachate has bee

Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?

Amyloid β peptide (Aβ42) assemblies are considered central to the development of Alzheimer's disease, but the mechanism of this toxicity remains unresolved. We screened protein microarrays with on-pathway oligomeric Aβ42 to identify candidate proteins interacting with toxic Aβ42 species. Samples prepared from Alexa546-Aβ42 and Aβ42 monomers at 1:5 molar ratio were incubated with the array during a

Societal services after traumatic spinal cord injury in Sweden

The article describes a survey of the societal services in Sweden that are available after a spinal cord injury. These services are allocated to allow independence and financial compensation. I have investigated the kinds of services that are available. I have also interviewed 34 of a total incidence population of 48 people, to find out which services were applied for, and to describe the levels o

Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors.

ABSTRACT: BACKGROUND: Urothelial carcinoma (UC) is characterized by nonrandom chromosomal aberrations, varying from one or a few changes in early-stage and low-grade tumors, to highly rearranged karyotypes in muscle-invasive lesions. Recent array-CGH analyses have shed further light on the genomic changes underlying the neoplastic development of UC, and have facilitated the molecular delineation a

När blev Jesus Guds Son?

Popular discussions over Jesus as the Son of God are mostly predetermined by the Creed or by a ”Christology from above”. Against this background the question on when Jesus began to be called ”Son of God” might be answered in a reductionist way, giving priority to the oldest and least developed forms of Christology. As a matter of fact, however, historical-critical exegesis has shown that titles an

Sahl and the Tājika Yogas: Indian transformations of Arabic astrology

This paper offers a positive identification of Sahl ibn Bishr’s Kitāb al-ʾaḥkām ʿalā ʾn-niṣba al-falakiyya as the Arabic source text for what is perhaps the most characteristic feature of the medieval Perso-Indian style of astrology known as tājika: the sixteen yogas or types of planetary configurations. The dependence of two late sixteenth-century tājika works in Sanskrit – Nīlakaṇṭha’s Tājikanīl

Behandling med intravenöst immunoglobulin vid neurologiska sjukdomar. Deskriptiv studie av effekter ur patientens och sjukvårdens perspektiv

We studied medical records for out-patient treatments with intravenous immunoglobulins during 2005 at the neurological clinics in Skåne and evaluated patient opinions using a questionnaire. Of 64 patients, 10 had started their therapy during the period, and 14 had it terminated. In five medical records doctor had defined and documented a therapy objective at the start of therapy and in six cases t

International network for comparison of HIV neutralization assays: the NeutNet report.

BACKGROUND: Neutralizing antibody assessments play a central role in human immunodeficiency virus type-1 (HIV-1) vaccine development but it is unclear which assay, or combination of assays, will provide reliable measures of correlates of protection. To address this, an international collaboration (NeutNet) involving 18 independent participants was organized to compare different assays. METHODS: Ea