PIWI-interacting RNAs (piRNAs) are important for ensuring the integrity of the germline. 3'-terminal 2'-O-methylation is essential for piRNA maturation and to protect them from degradation. HENMT1 (HEN Methyltransferase 1) carries out the 2'-O-methylation, which is of key importance for piRNA stability and functionality. However, neither the structure nor the catalytic mechanism of mammalian HENMT

In Sweden, the governance of healthcare is decentralized, so PC is provided with regional or local differences in organization, level of competence, and recourses. Ongoing regional and national initiative to increase quality of pediatric palliative care in Sweden aligns with the international standard of pediatric palliative care as a care directed towards all children with life-threatening or lif

Prostate cancer is the predominant cause of cancer in men, but there is still a lack of biomarkers and treatments for metastatic spread. The initial promise of microRNAs to provide avenues to solve these problems has been dampened by the realisation that microRNAs co-exist in multiple functionally distinct isoforms, for example due to A-to-I editing. We recently found that A-to-I-editing of microR

The early career professionals in the field of Cardiovascular Magnetic Resonance (CMR) face unique challenges and hurdles while establishing their careers in the field. The Society for Cardiovascular Magnetic Resonance (SCMR) has expanded the role of the early career section within the society to foster the careers of future CMR leaders. This paper aims to describe the obstacles and available oppo

In 1617, after seven years of war between Sweden and Russia and talks facilitated by English and Dutch diplomats, the peace treaty of Stolbovo was signed. This important but little-studied document was to form the basis for relationships between Sweden and Russia for the next one hundred years, before it was replaced by the Peace of Nystad in 1721, and it had a huge influence on the lives of the p

I denna artikel studerar vi upplevelser av makt hos regionala utvecklingsledare i svenska regionala stöd- och samverkansstrukturer (RSS) inom statens styrning av socialtjänsten. Artikeln besvarar två frågor: 1) utvecklingsledarnas erfarenheter av makt i vertikala och horisontella styrrationaliteter i statlig kunskapsstyrning, och 2) vilken betydelse dessa erfarenheter har för deras förståelse av s

Med utgångspunkt i historiska och empiriska beskrivningar av offentliga och privata badanläggningar i Japan undersöker denna artikel kulturella betydelser i japanska badvanor. Genom att undersöka nakenhet och varmt vatten som förmedlare av närhet och intim socialitet i Japan, utmanar artikeln gränserna mellan den privata och offentliga sfären och det intima och sociala. Artikeln visar att badvanorBased on historical and empirical descriptions of bathing practice in public bath-houses and private bathing facilities in Japan, this article examines cultural meanings embedded in Japanese bathing practice. The article explores the relation between Japanese bathing practice and notions of the private and the public spheres as well as intimacy and sociality. By studying naked skin and hot water a

The role of consumers in a circular economy (CE) is crucial but not well understood in the literature. For consumers to become catalysts in a CE, people need to understand how and under what conditions circular consumption is made possible. This chapter conceptualises the sociomaterial assembling of circular consumption, which refers to the process in which heterogeneous elements – meanings, mater

DOCTORAL DISSERTATIONDoctoral dissertation for the degree of Doctor of Philosophy (PhD) at the Faculties of Humanities and Theology at Lund University to be publicly defended on the 14th of February at 13.00 in room LUX:B336, Lund University Cognitive Science, Helgonavägen 3, LundFaculty opponent:Professor Dr. Claudia Männel, LeipzigIn the present thesis, brainwaves analyzed as event-related poten

Online platforms devoted to investigating criminal cases or mysteries are often seen as reaching outwards to identify suspects, promote punishment, and try to solve cases. Simultaneously, internal interactions between posters motivate them to contribute, even to outdo one another, and so a team spirit emerges. This article analyzes a lengthy thread on a Swedish Internet discussion forum, FlashbackOnline platforms devoted to investigating criminal cases or mysteries are often seen as reaching outwards to identify suspects, promote punishment, and try to solve cases. Simultaneously, internal interactions between posters motivate them to contribute, even to outdo one another, and so a team spirit emerges. This article analyzes a lengthy thread on a Swedish Internet discussion forum, Flashback

In the cuprate superconductors, the spatial coherence of the charge density wave (CDW) state grows below a temperature TCDW, the origin of which is debated. Using x-ray photon correlation spectroscopy, we have studied the temporal atomic relaxation dynamics in La1.88Sr0.12CuO4 to shed light on this question. Cooling within an emergent structurally distorted phase, which favors the CDW modulation i

The deteriorating security environment in Europe due to the increasing conflict of interests between western democracies and Russia is now, after the Russian invasion of Ukraine, obvious to all. But the willingness of the Russian state to oppose and disrupt European security order and the sovereignty of other states is not new. One increasingly common way is using influence operations, often in co

This article analyses infant and child sex ratios in late Imperial Russia relying on district-level information obtained from the 1897 Russian census (489 districts). The article shows that child sex ratios were, on average, relatively low (around 98 boys per hundred girls) due to the biological female advantage: the extremely high infant and child mortality rates took a greater toll on boys and p

Aims Our objective was to assess changes in the birth prevalence of CHD over a half-century in a high-resource, nationwide setting, as well as changes in the prevalence of cardiac interventions in this population. Methods The Swedish National Patient and Cause of Death registers were linked to estimate the annual rates of CHD and cardiac and results interventions among live-born infants from 1970

Medical adhesive tapes are commonly recommended for the prevention of friction blisters during hiking and military marches. The aim of this paper is to report on the results of investigations into an outbreak of taperelated foot dermatitis in 26 military conscripts following continuous use of medical adhesive tapes for several days during a field exercise. Patch tests were performed using baseline

This paper presents a 4-channel time-interleaved (TI) analog-to-digital converter (ADC), where each channel is comprised of a two-stage pipelined asynchronous successive-approximation (ASAR) sub-ADC. The ADC employs two samplers to alleviate the problem of timing skew on the sub-sampler when distributing the clock to the TI channels. To further increase the speed of the ADC, the reset switch in th

Public discourse and political climate policymaking are based on scientific reports and propose technological solutions to solve the crisis, primarily by changing fossil fuels to renewable energy. Rather than questioning growth and the overuse of natural resources—which has been at the core of green concern for decades—green growth is the motor in an economy that aims for continuous economic spin,