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Släpp politikerna loss - det är vår hamn

En reflektion kring ett politiskt beslut som togs i Göteborg 2020. Politikerna kom överens om att nu måste det nya som byggs vid Skeppsbron i Göteborg få en klassisk utformning. De menar att med klassisk och traditionell arkitektur blir invånarna och besökare nöjdare. Beslutet retade upp många arkitekter.

A bird's eye-view of smallholder productivity : Current measurement shortfalls, farmer perceptions and rationality on rainfed family farms in Ghana

Smallholder farming, which is largely rainfed and relies on mostly rudimentary tools, predominates Ghana’s agricultural sector. The sector’s importance to the national economy is exemplified in not only the proportion of the active national labour force engaged in it but also in terms of its export earnings and service as a source of food for the vast majority of the population. However, the secto

Aspects of infective endocarditis. Molecules, microbiology, management, and more.

AbstractEndocarditis, or heart valve infection, can be caused by a number of pathogens, many of which are Gram-positive bacteria. The diagnosis is based on imaging techniques such as echocardiography and on blood culture. The implementation of fast and accurate species identification methods, such as the matrix-assisted laser desorption/ionisation-time of flight mass spectrometry (MALDI-TOF MS) in

Representing quantitative documentation of 3D cultural heritage artefacts with CIDOC CRMdig

In this paper, we will explore the theme of the documentation of 3D cultural heritage assets, not only as entire artefacts but also including the interesting features of the object from an archaeological perspective. Indeed, the goal is supporting archaeological research and curation, providing a different approach to enrich the documentation of digital resources and their components with correspo

Who Needs 3D When the Universe Is Flat?

An overlooked feature in astronomy education is the need for students to learn to extrapolate three-dimensionality and the challenges that this may involve. Discerning critical features in the night sky that are embedded in dimensionality is a long-term learning process. Several articles have addressed the usefulness of three-dimensional (3D) simulations in astronomy education, but they have neith

Enforcing the Responsibility to Protect Through Solidarity Measures

Responsibility to Protect (R2P) provides a moral basis for collective action through the UN Security Council in reaction to mass atrocity situations. However, this avenue is not always available. The question then arises whether other actors can and should assume responsibility in such circumstances and, if so, which kinds of measures they may pursue. The present article examines this question wit

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

Synaptic dysfunction is increasingly viewed as an early manifestation of Alzheimer's disease (AD), but the cellular mechanism by which β-amyloid (Aβ) may affect synapses remains unclear. Since cultured neurons derived from APP mutant transgenic mice secrete elevated levels of Aβ and parallel the subcellular Aβ accumulation seen in vivo, we asked whether alterations in synapses occur in this settin

Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation

Intrinsic optical emissions, such as autofluorescence and second harmonic generation (SHG), are potentially useful for functional fluorescence imaging and biomedical disease diagnosis for neurodegenerative diseases such as Alzheimer's disease (AD). Here, using multiphoton and SHG microscopy, we identified sources of intrinsic emissions in ex vivo, acute brain slices from AD transgenic mouse models

Testosterone reduces neuronal secretion of Alzheimer's β-amyloid peptides

Alzheimer's disease (AD) is characterized by the age-related deposition of β-amyloid (Aβ) 40/42 peptide aggregates in vulnerable brain regions. Multiple levels of evidence implicate a central role for Aβ in the pathophysiology of AD. Aβ peptides are generated by the regulated cleavage of an ≃700-aa Aβ precursor protein (βAPP). Full-length βAPP can undergo proteolytic cleavage either within the A β

Highly selective effects of nerve growth factor, brain‐derived neurotrophic factor, and neurotrophin‐3 on intact and injured basal forebrain magnocellular neurons

Cholinergic neurons of the basal nucleus complex (BNC) respond to nerve growth factor (NCF), the first member of a polypeptide gene family that also includes brain‐derived neurotrophic factor (BDNF), neurotrophin‐3 (NT‐3), and neurotrophin‐4/5 (NT‐4/5), NGF, BDNF, and NT‐3 are enriched in hippocampus. In addition, NGF and, more recently, BDNF have been shown to stimulate the cholinergic differenti