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A novel bio-electronic tongue using different cellobiose dehydrogenases to resolve mixtures of various sugars and interfering analytes.

A novel application of cellobiose dehydrogenase (CDH) as sensing element for a Bioelectronic Tongue (BioET) system has been tested. In this work CDHs from various fungi, which exhibit different substrate specificities, were used to discriminate between lactose and glucose in presence of the interfering matrix compound Ca(2+) in various mixtures. This work exploits the advantage of an electronic to

The early life origins of vascular ageing and cardiovascular risk: the EVA syndrome.

Early vascular ageing is common in patients with hypertension and increased burden of cardiovascular risk factors, often influenced by chronic inflammation. One aspect of this vascular ageing is arterial stiffening, as measured by increased pulse wave velocity or augmentation index and central pressure. Several studies have indicated that this process starts early in life and that arterial functio

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Forays in Estonia: Experiences from participation in an excavation om St Michaels monastery in Tallinn, Estonia.

Ultrasound weight estimation of large fetuses.

Objective: To compare the accuracy of fetal weight estimation in large fetuses using four ultrasound formulas. Design: Prospective comparative study. Setting: University Hospital, Lund, Sweden. Population: Large-for-gestational age fetuses (n = 114) at a routine ultrasound examination in the third trimester. Methods: Persson & Weldner two-dimensional formula was compared with Hart et a

The European registry of quality outcomes for cataract and refractive surgery (EUREQUO): a database study of trends in volumes, surgical techniques and outcomes of refractive surgery.

A European web-based registry for refractive surgery was established in 2008; The European Registry of Quality Outcomes for Cataract and Refractive Surgery (EUREQUO). The aim of the registry was to improve treatment and standards of care for refractive surgery. Further aims were to offer a tool for benchmarking by establishing a reference database and for surgeons to enter and analyze their own ou

Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential.

Reports on the retention of somatic cell memory in induced pluripotent stem cells (iPSCs) have complicated the selection of the optimal cell type for the generation of iPSC biobanks. To address this issue we compared transcriptomic, epigenetic, and differentiation propensities of genetically matched human iPSCs derived from fibroblasts and blood, two tissues of the most practical relevance for bio

Knowledge Bases and Spatial Patterns of Collaboration: Comparing the Pharma and Agro-Food Bioregions Scania and Saskatoon

The aim of this paper is to compare the spatial patterns of innovation and knowledge linkages of a biopharmaceutical and an agro-food biotech cluster. Dissimilarities can be expected based on substantial differences in terms of historical technological regimes and sectoral innovation system dynamics between the agro-food and pharmaceutical industries in general and particularly the distinctive ana

Exploring the Railway System from a Risk Governance Perspective

Popular Abstract in Swedish Olyckor i järnvägssektorn kan ge upphov till katastrofala konsekvenser. I första hand kan människors liv och hälsa drabbas, men allvarliga konsekvenser kan även uppstå för samhället i stort. Detta beror på att järnvägssystemet, liksom en rad andra infrastruktursystem är väsentliga för att vårt moderna samhälle ska fungera. Under de senaste decennierna har dessa system bIn recent decades, the Swedish railway system has faced substantial deregulations. As a result, management of risk is often carried out in settings involving multiple stakeholders having various roles, mandates, and viewpoints on risk, and where no single stakeholder has the superior authority. In order to manage risks in this type of multi-actor setting, the traditional elements of risk assessmen

On the use of sequential Monte Carlo methods for approximating smoothing functionals, with application to fixed parameter estimation

Sequential Monte Carlo (SMC) methods have demonstrated a strong potential for inference on the state variables in Bayesian dynamic models. In this context, it is also often needed to calibrate model parameters. To do so, we consider block maximum likelihood estimation based either on EM (Expectation-Maximization) or gradient methods. In this approach, the key ingredient is the computation of smoot

Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues

Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous

Cardiovascular Risk, Cardiac Function, Physical Activity, and Quality of Life with and without Long-Term Growth Hormone Therapy in Adult Survivors of Childhood Acute Lymphoblastic Leukemia.

Context: Long-term data are missing in GH-treated acute lymphoblastic leukemia (ALL) patients. GH therapy may result in poorer outcome regarding cardiovascular (CV) and particularly cardiac effects than in patients with hypothalamic-pituitary disease. Objective: Our objective was to evaluate GH therapy on CV risk, cardiac function, physical activity, and quality of life in ALL patients treated wit