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Clinical chemistry’s special issue on men’s health
Androgen deprivation therapy potentiates the efficacy of vascular targeted photodynamic therapy of prostate cancer xenografts
Purpose: WST11 vascular targeted photodynamic therapy (VTP) is a local ablation approach relying upon rapid, free radical-mediated destruction of tumor vasculature. A phase III trial showed that VTP significantly reduced disease progression when compared with active surveillance in patients with low-risk prostate cancer. The aim of this study was to identify a druggable pathway that could be combi
Vasectomy and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Purpose Vasectomy is a commonly used form of male sterilization, and some studies have suggested that it may be associated with an increased risk of prostate cancer, including more aggressive forms of the disease. We investigated the prospective association of vasectomy with prostate cancer in a large European cohort, with a focus on high-grade and advanced-stage tumors, and death due to prostate
Reply to Re : The Memorial Sloan Kettering Cancer Center Recommendations for Prostate Cancer Screening
The Memorial Sloan Kettering Cancer Center Recommendations for Prostate Cancer Screening
The Memorial Sloan Kettering Cancer Center (MSKCC) recommendations on prostate cancer screening were developed in response to three limitations of previous screening guidelines: insufficient evidence base, failure to link screening with treatment, and lack of risk stratification. The objective of the recommendations is to provide a schema for prostate cancer screening that maximizes the benefits,
Clinical Consultation Guide : How to Optimize the Use of Prostate-specific Antigen in the Current Era
Optimizing the benefits versus harms of prostate-specific antigen screening can be achieved through stratifying screening and biopsy. This clinical consultation guide provides the scientific background and evidence-based recommendations.
An analysis of the association between prostate cancer risk loci, PSA levels, disease aggressiveness and disease-specific mortality
Genome-wide association studies have identified multiple single-nucleotide polymorphsims (SNPs) associated with prostate cancer (PCa). Although these SNPs have been clearly associated with disease risk, their relationship with clinical outcomes is less clear. Our aim was to assess the frequency of known PCa susceptibility alleles within a single institution ascertainment and to correlate risk alle
Liberation
Aminopeptidase activities as prospective urinary biomarkers for bladder cancer
Purpose: Proteases have been implicated in cancer progression and invasiveness. We have investigated the activities, as opposed to simple protein levels, of selected aminopeptidases in urine specimens to serve as potential novel biomarkers for urothelial cancer. Experimental design: The unique urinary proteomes of males and females were profiled to establish the presence of a gender-independent se
Analytic and clinical validation of a prostate cancer-enhanced messenger RNA detection assay in whole blood as a prognostic biomarker for survival
Background Biomarkers based on detecting prostate cancer (PCa)-specific transcripts in blood are associated with inferior outcomes, but their validation in a clinical context is lacking. Objective To determine whether detecting enhanced transcripts for PCa in whole blood using an analytically valid assay has prognostic significance relative to circulating tumor cell (CTC) enumeration. Design, sett
Enemy of Humanity or Freedom Fighter? The ‘Jihadist’ Foreign Combatant in the Syrian Civil War
Support for sustainable welfare? : A study of public attitudes related to an eco-social agenda among Swedish residents
Denna avhandling undersöker den svenska befolkningens attityder i förhållande till en ekosocial agenda utifrån ett hållbart välfärdsperspektiv. Forskare har länge angripit frågor om miljö och välfärd som två separata fält. De aktuella miljö- och klimatförändringarna visar dock att dessa två fält måste förstås i samklang med varandra om vi ska kunna ställa om till ett klimatneutralt samhälle där håThis thesis explores Swedish residents’ attitudes related to an eco-social agenda from a sustainable welfare perspective. It investigates public support for general policy goals related to an eco-social agenda as well as for specific eco-social policies. The thesis also analyses the significance of the individuals’ socioeconomic characteristics, their values, and the context they are situated in r
Evaluating the Prostate Cancer Prevention Trial High Grade prostate cancer risk calculator in 10 international biopsy cohorts : Results from the prostate biopsy collaborative group
Objectives: To assess the applicability of the Prostate Cancer Prevention Trial High Grade (Gleason grade ≥ 7) Risk Calculator (PCPTHG) in ten international cohorts, representing a range of populations. Methods: A total of 25,512 biopsies from 10 cohorts (6 European, 1 UK and 3 US) were included; 4 implemented 6-core biopsies, and the remaining had 10 or higher schemes; 8 were screening cohorts, a
Bidirectional associations of intellectual and social activities with cognitive function among middle-aged and elderly adults in China
Background: Previous studies evaluating the association between leisure activities and cognitive function produced conflicting results. Different types of leisure activities may have different effects on cognition, and very few studies have explored their bidirectional associations. Our study aimed to explore whether intellectual and social activities had bidirectional associations with cognitive
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Martti Koskenniemi, Walter Rech, and Manuel Jiménez Fonseca (eds.), International Law and Empire: Historical Explorations
Emerging PSA-based tests to improve screening
This article updates advances in prostate cancer screening based on prostate-specific antigen, its derivatives, and human kallikrein markers. Many men are diagnosed with indolent disease not requiring treatment. Although there is evidence of a survival benefit from screening, the numbers needed to screen and treat remain high. There is risk of exposing men to the side effects of treatment for nont
The Making of International Human Rights: The 1960s, Decolonization, and the Reconstruction of Global Values
Ghosts of International Law: The Figure of the Foreign Fighter in a Cultural Perspective
Heroes and villains, idealists and mercenaries, freedom fighters and religiousfanatics. Foreign fighters tend to defy easy classification. Good andbad images of the foreign combatant epitomize different conceptions offreedom and are used to characterize the rightness or wrongness of thisactor in civil wars. This book traces the history of these figures and theirafterlife. It does so through an int