Background: Following exposure to traumatic stress, women are twice as likely as men to develop mood disorders. Yet, individual responses to such stress vary, with some people developing stress-induced psychopathologies while others exhibit resilience. The factors influencing sex-related disparities in affective disorders as well as variations in resilience remain unclear; however, emerging eviden

We compared five groups of students to investigate the effects of ”Just-in-time teaching” (JiTT), a method designed to both help students keep up with the often fast pace of undergraduate calculus and to deepen their learning. In total, 137 students participated in the study. The outcome is discussed in terms of conceptual and procedural knowledge in relation to examination and other assessment ta

Materials with heterogeneous microstructures architected across several scales are becoming increasingly popular in structural applications due to unique strength–ductility balance. One of the most popular 3D-architected structure designs is harmonic structure (HS) where soft coarse-grain (CG) islands are embedded in a hard continuous 3D skeleton of ultrafine grains (UFGs). In this work, a series

DNA mismatch repair (MMR) is thought to contribute to the onset and progression of Huntington disease (HD) by promoting somatic expansion of the pathogenic CAG nucleotide repeat in the huntingtin gene (HTT). Here we have studied constitutional HTT CAG repeat size in two cohorts of individuals with Lynch syndrome (LS) carrying heterozygous loss-of-function variants in the MMR genes MLH1 (n = 12/60;

We introduce benchmarking analysis based on state-of-the-art machine learning techniques applied to the measurement of efficiency to assess the performance of Higher Education Institutions (HEIs). We rely on Efficiency Analysis Trees (EAT) and its Convexified frontier counterpart (CEAT) to assess the efficiency of 144 private HEIs in Colombia and compare the results with those achieved with classi

Cognitive skills affect individual choices. Researchers commonly use Raven's Progressive Matrices (RPM) tests and the Cognitive Reflection Test (CRT) to assess the relationship between cognitive abilities and economic decision making. In this paper, we study the relationship between these measures, and investigate the extent to which they are correlated and whether they are best described as subst

A student at a university, let us call him John, was always the first to answer questions posed by the teacher. Problems that took 15 minutes for his peers to solve took him a split second. John attended all compulsory lectures, but he did not do all compulsory tasks and hence did not pass the course. He was always late and not very focused on the course, other than on occasional problems posed by

Pollutions on and within the underground poses risks for groundwater contamination and is a widespread global problem. Common remediation methods based on digging and removal can be expensive and have limitations, while in-situ remediation is an attractive alternative. However, there is a need to develop tools to monitor the effectiveness both in terms of the successful injection of remediation fl

Standard treatment for patient with peritoneal metastases from colorectal cancer is cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). In recent years, the efficacy of oxaliplatin-based HIPEC has been challenged. An intensified HIPEC (oxaliplatin+irinotecan) in combination with early postoperative intraperitoneal chemotherapy (EPIC) has shown increased recurrence-fr

Lipid nanopartiklar, förkortat LNP, används bland annat vid cancerbehandling och vaccinutveckling. Deras funktion är att transportera och skydda verksamma ämnen såsom antikroppar, proteiner och peptider. Ett välkänt exempel är coronavaccinet, där LNP transporterar mRNA och skyddar det från att brytas ner i kroppen. Lipid nanopartiklar består av olika lipider: positivt laddade, fosfolipider, kolestOver the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. Specifically, Polysorbate 80 (P80), a

OBJECTIVES: Head and neck cancer (HNC) is the sixth most common cancer worldwide. The condition and its treatment often lead to marked morbidities and, for some patients, premature death. Inferentially, HNC imposes a significant economic burden on society. This study aims to provide a comprehensive and detailed estimation of the cost of illness of HNC for Sweden in 2019.METHODS: This is a prevalen

Cardio-metabolic traits have been reported to be associated with the development of sepsis. It is, however, unclear whether these co-morbidities reflect causal associations, shared genetic heritability, or are confounded by environmental factors. We performed three analyses to explore the relationships between cardio-metabolic traits and sepsis. Mendelian randomization (MR) study to evaluate the c

Aim: To provide a comprehensive description of the clinical features, biochemical characteristics, and outcomes of infants up to 90 days old with COVID-19. Moreover, to assess the severity of the disease and propose an effective management pathway. Methods: Retrospective single-center study spanning three years. Patient data includes age, sex, symptoms, comorbidities, blood and urine test results,

The world is transitioning towards a renewable energy system to combat climate change and the wind power industry plays a key role in this shift. However, with the expansion of wind power concerns about its impact on local biodiversity have been raised. This thesis investigates the incentives, regulations, and challenges that are influencing biodiversity management in the wind power industry. Thro

PCDD/Fs and dl-PCBs, or more commonly referred to as dioxin and dioxin like substances are compounds present in our surrounding environment. As some congeners of these have been shown to be toxic, they are regulated under the Stockholm Convention. As dioxins are persistent in biota and have lipophilic properties they are seen accumulating in lipid rich fish in the Baltic, one of the affected speci

Pharmacometric modeling plays an important role in drug development and personalized medicine. Pharmacometric covariate models can be used to describe the relationships between patient characteristics (such as age and weight) and pharmacokinetic (PK) parameters. Traditionally, the functional structure of these relationships are obtained manually. This is a time-consuming task, and consequently lim

När man talar om elbussar framhålls ofta deras påverkan på stadsmiljöer, exempelvis vad gäller urbana kvaliteter som luftkvalitet och buller, eller hur etableringen av laddinfrastruktur ska anpassas till både den urbana kontexten och till kollektivtrafikens förutsättningar. Sedan de första elbussarna introducerades i svenska städer för ca 10 år sedan har det funnits förväntningar på att elektrifie

In 2005 the Swedish Association of the Pharmaceutical Industry (LIF) initiated a national environmental classification and information system for pharmaceuticals. This investigation reports the results from a survey, conducted among the persons involved in the start-up process. The aim of this study is to generate knowledge contributing to the clarification of the motivations, expectations, and in

The size of the authentication tag represents a significant overhead for applications that are limited by bandwidth or memory. Hence, some authenticated encryption designs have a smaller tag than the required privacy level, which was also suggested by the NIST lightweight cryptography standardization project. In the ToSC 2022, two papers have raised questions about the IND-CCA security of AEAD sch