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Breast cancer is a very heterogeneous disease in terms of clinical characteristics, genetic aberrations and prognosis. In Paper I, we focused on the CD44 molecule that often is aberrantly expressed in breast cancer and is widely used as a marker for cancer stem cells. Several isoforms of the CD44 molecule were analyzed at the transcriptome level across breast tumors and the expression of individua
The interactions of biological macromolecules with nanoparticles underlie a wide variety of current and future applications in the fields of biotechnology, medicine and bioremediation. The same interactions are also responsible for mediating potential biohazards of nanomaterials. Some applications require that proteins adsorb to the nanomaterial and that the protein resists or undergoes structural
Background: The innate immune system contributes to the outcome after stroke, where neuroinflammation and post-stroke systemic immune depression are central features. Tumor necrosis factor (TNF), which exists in both a transmembrane (tm) and soluble (sol) form, is known to sustain complex inflammatory responses associated with stroke. We tested the effect of systemically blocking only solTNF versu
Partially Premixed Combustion (PPC) is a combustion concept by which it is possible to get low smoke and NOx emissions simultaneously. PPC requires high EGR levels to extend the ignition delay so that air and fuel mix prior to combustion to a larger extent than with conventional diesel combustion. This paper investigates the operating region of single injection PPC for three different fuels; Diese
This survey, "Life and Health-Young People 2005," included all 15/16-year-old adolescents in mainstream schools in the county of Orebro, Sweden. just students with a slight/mild or moderate hearing loss were included. There were 56 (1.9%) "hard-of-hearing (HH) students with multiple disabilities," 93 (3.1%) students who were "just HH," 282 (9.7%) students with some "other disability than HH," and
Projekt Turnstone är ett samverkansprojekt delvis finansierat av Europeiska kommissionen. Projektet är ett initiativ av Stockholmspolisens gränsbevakningsenhet. Syftet med Projekt Turnstone är att minska gränsöverskridande brottslighet, förbättra dagligt samarbete mellan gräns, polis och kustbevakare i Östersjöregionen och förbättra säkerheten för passagerare i Östersjöregionen utan att göra avkalProject Turnstone is a collaborative project funded in part by the European Commission. The project is an initiative by the Stockholm Police. The purpose of the project is to improve day-to-day cooperation between border officers in the Baltic Sea region, decrease trans-boundary criminality, and increase security for passengers in the Baltic Sea area without compromising freedom of movement. Withi
Popular Abstract in Swedish Människans immunförsvar ska hjälpa oss att bekämpa infektioner från bakterier och virus. Immunförsvaret kan delas in i två delar; det adaptiva immunförsvaret, som utvecklas hela tiden under livets gång, samt det medfödda immunförsvaret. De flesta känner kanske till att kroppen kan utveckla antikroppar mot bakterier. Antikroppar känner igen och markerar ut främmande struAbstract: The joint diseases osteoarthritis and rheumatoid arthritis are characterized by destructive inflammatory processes that result in pathological changes of the joint tissues, including proteolytic degradation of cartilage and release of extracellular matrix proteins or fragments to the synovial fluid. The complement system, which is a part of the innate immune system, plays a central role
The Ebola virus (EBOV) RNA-dependent RNA polymerase (RdRp) complex consists of the catalytic subunit of the polymerase, L, and its cofactor VP35. Using immunofluorescence analysis and coimmunoprecipitation assays, we mapped the VP35 binding site on L. A core binding domain spanning amino acids 280-370 of L was sufficient to mediate weak interaction with VP35, while the entire N-terminus up to amin
Popular Abstract in Swedish Bland infektionssjukdomarna är Enterobacteriaceae den viktigaste gruppen av bakterier. Den kan orsaka ett flertal olika infektioner så som blodförgiftning, urinvägsinfektion, hjärnhinneinflammation, bukhinneinflammation, gallvägsinfektioner, lunginflammation och diarrésjukdomar. Den vanligaste orsaken till blodförgiftning är bakterier som har kommit in i blodet från uriIn human medicine, the most important family of bacteria is Enterobacteriaceae, which includes genera and species that cause well-defined diseases and also nosocomial infections. These bacteria can give rise to numerous infections such as septicaemia and urinary tract infections. It is important to combat these infections with effective antibiotics, because many of them are associated with high mo
Cationic vinylpyridine based molecularly imprinted polymer monoliths were, for the first time, applied to enantiomer separation using capillary electrochromatography. In order to map the synthesis conditions under which superporous monoliths are obtained, capillary columns were prepared by an in situ polymerization technique using varying monomer and porogen compositions. Both electrolyte pH and p
The integrated model WORLD and Hubbert's model were used for assessment of future supply for different metals: iron, nickel, manganese, chromium, molybdenum, tantalum, niobium, rhenium, zir- conium, tungsten, cobalt, copper, zinc, lead, aluminium and the technology metals derived from copper ezinc mining (tellurium, selenium, gallium, indium, antimony, bismuth, tin, germanium, selenium). The conne
Kidney cancer and renal injuries affect millions of people in the world resulting in high patient morbidity and mortality, as well as one of the most extensive medical costs for society. Upon renal injury the kidney has an endogenous ability to repair damaged tubules and restore kidney function, provided that the patient receives adequate supportive care in time. The molecular basis for this regen
We here describe the result of simulations of 15 generic neutron instruments for the long-pulsed European Spallation Source. All instruments have been simulated for 20 different settings of the source time structure, corresponding to pulse lengths between 1 ms and 2 ms; and repetition frequencies between 10 Hz and 25 Hz. The relative change in performance with time structure is given for each inst
Directive 2008/96/EC on road infrastructure safety management requires the establishment and implementation of procedures relating to road safety impact assessments (RSIA), road safety audits (RSA), ranking of high accident concentration sections and network safety ranking (NSR) and road safety inspections (RSI). The aim of this article is to present the outputs of BALTRIS project. The goal of the
It is not known if verum (real) acupuncture is effective for nausea and vomiting (emesis) during radiotherapy. We randomly treated 215 blinded cancer patients with verum: penetrating 'deqi' creating acupuncture (n = 109) or non-penetrating sham needles (n = 106) two to three times per week. The patients documented emesis daily during the radiotherapy period. Primary end point was the number of pat
