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Popular Abstract in Swedish Endokrina och metabola sjukdomstillstånd har många gemensamma komponenter. Att förstå de signalvägar som ligger till grund för dessa sjukdomar hjälper oss att utveckla bättre behandlingsmetoder. Det övergripande syftet med min forskning är att undersöka den roll s.k. G-protein kopplade receptorer spelar i endokrina metaboliska sjukdomar, mer specifikt de signalvägar somThe aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) throug

A key to successful chronic neural interfacing is to achieve minimal glial scarring surrounding the implants, as the astrocytes and microglia may functionally insulate the interface. A possible explanation for the development of these reactions is mechanical forces arising between the implants and the brain. Here, we show that the difference between the density of neural probes and that of the tis

This article explores the symbolic aspects of change agency on a learning platform designed to facilitate system-wide transformation in cancer care. A sensemaking-sensegiving perspective is adopted to analyse the construction of meaning amongst of the leader of a regional cancer centre, senior physicians and an action research team in relation to patient-centred care. The analysis suggests that th

FTIR imaging was performed on pig ear skin samples cryo-sectioned perpendicular to the skin surface. The OH-stretch region revealed the distribution of water; the amide II band gave the protein distribution; the C=O stretch and C-H stretch regions showed the variation in lipids. Water and proteins were similarly distributed. Triglycerides were predominantly found in the deeper skin layers whereas

This paper discusses compact node-link formulations for MPLS fast reroute optimal single path layout. We propose mathematical formulations for MPLS fast reroute local protection mechanisms. In fact, we compare one-to-one (also called detour) local protection and many-to-one (also called facility backup) local protection mechanisms with respect to minimized maximum link utilization. The optimal res

Background: Sacroiliitis in ankylosing spondylitis has frequently been graded radiographically using the New York (NY) criteria, which also have been applied in computed tomography (CT). Purpose: To validate the grading of the NY criteria in CT of the sacroiliac joints. Material and Methods: With the aid of the NY criteria, assessment of inflammatory and degenerative changes was made in 1304 CT st

By discussing Sophie Leijonhufvud’s Swedish translation of Dinah Mulock’s A Woman’s Thoughts about Women (1858, transl. 1861) this article investigates how the agenda of the translator and editor may affect the target text, for instance by altering the implied reader and by assuming an additional authorial voice.

Et konferenspaper som belyser de centrala delarna av min kommande avhandling där effekter av långvarig arbetslöhset och socialbidragsbehov hos unga med omfattande arbetsmarkandsproblematik alltsedan 1990-talet belyses.Texten visar på den omfattande skam och och ovilja till socialbidragsberoende studiens respondenter uttrycker.

Objective-To evaluate the use of CT and MRI for guidance of osteochondral sample collection for histologic detection of early osteoarthritic lesions in centrodistal (distal intertarsal) joints of horses. Sample-Right tarsal joints from the cadavers of 24 Icelandic horses aged 29 to 31 months. Procedures-CT and MRI were used to evaluate the extent of suspected osteoarthritic changes in centrodistal

We report on fabrication and optical characterization of GaAs nanopillar (NP) arrays, obtained using a combination of low-cost mask generation by self-assembled silica particles (nanosphere lithography) and dry etching. Tapered structures (conical and frustum NP arrays) are fabricated by appropriate optimization of process parameters. Significant suppression of surface reflectance is observed for

Safety performance functions are frequently used to describe the relation of various factors to the number of accidents, often focusing on exposure of vulnerable road users. Those studies require reliable data regarding exposure, but collecting such data is resource demanding, often resulting in short observational periods. This might produce measurement errors, influencing the reliability of the

Antineutrophil cytoplasm autoantibodies (ANCA) directed against bactericidal/permeability-increasing protein (BPI) are common in patients with cystic fibrosis (CF), and serum levels are correlated with lung colonization by Pseudomonas aeruginosa and the severity of lung damage. The production of BPI-ANCA may be due to the costimulation of BPI when mounting an immune response against P. aeruginosa.

Research on management consultancy usually emphasizes the rote and perspective of the consultants. Whilst important, consultants are only one element in a dynamic relationship involving both consultants and their clients. In much of the literature, the client is neglected, or is assumed to represent a distinct, immutable entity. In this paper, we argue that the client organisation is not uniform b

Classical continuum mechanics is used extensively to predict the properties of nanoscale materials such as graphene. The bending rigidity, kappa, is an important parameter that is used, for example, to predict the performance of graphene nanoelectromechanical devices and also ripple formation. Despite its importance, there is a large spread in the theoretical predictions of kappa for few-layer gra

By catalyzing hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), cyclic nucleotide phosphodiesterases are critical regulators of their intracellular concentrations and their biological effects. As these intracellular second messengers control many cellular homeostatic processes, dysregulation of their signals and signaling pathways initiate or modulate p

Despite weak evidence, the use of acupuncture has increased in infantile colic. The only three randomized trials conducted evaluated standardized minimal acupuncture in one single point. Two showed effect but one did not so further research is necessary. The aims of the study are 1) to test if results in earlier trials conducted in private acupuncture clinics can be repeated at Child Health Center

This contribution highlights recent results from the PHENIX Collaboration at RHIC with emphasis on those obtained through lepton and photon measurements in PHENIX.