At the catalytic site for the hydrolysis of cellulose the enzyme cellobiohydrolase Cel7A binds the enantiomers of the adrenergic beta-blocker propranolol with different selectivity. Methyl-to-hydroxymethyl group modifications of propranolol, which result in higher affinity and improved selectivity, were herein studied by 1H,1H and 1H,13C scalar spin–spin coupling constants as well as utilizing the

General analysis of expected per-terminal signalto-interference-plus-noise-ratio (SINR) and ergodic per-cell sum spectral efficiency for a multi-cellular system with coordinated regularized zero-forcing (RZF) precoding is presented.An application to two-tier small-cell networks is considered, assuming independent and identically distributed (i.i.d.) and semi-correlated Rayleigh fading channels, wi

Closed-form approximations to the expected perterminal signal-to-interference-plus-noise-ratio (SINR) and ergodic sum spectral efficiency of a large multiuser multiple-input multiple-output system are presented. Our analysis assumes correlated Ricean fading with maximum ratio combining on the uplink, where the base station (BS) is equipped with a uniform linear array (ULA) with physical size restr

The quest for fundamental scientific knowledge triggers technological advancement. This has been particularly true for attosecond science in recent years: we assisted in the development of many new approaches - both experimentally and theoretically - that will have a high impact, not only on atomic and molecular physics, but also on optical technology. This special issue collects several of these

A general framework for the analysis of expected per-user signal-to-interference-plus-noise-ratio (SINR) of a multiuser multiple-input-multiple-output system is presented. Our analysis assumes spatially correlated Rayleigh fading channels with regularized zero-forcing precoding on the downlink. Unlike previous works, our analytical expressions are averaged over the eigenvalue densities of the comp

In this paper, we present two important contributions. The first is demonstration of the use of subliminal levels of pseudo-random noise to enhance channel estimation, and the second is a joint time and frequency domain algorithm for multichannel inversion. An adaptive system is presented where the acoustic channel is accurately estimated and utilized. In this implementation, maximum length sequen

Bumblebees are important pollinators for a wide range of crops and wild plants. Performance of their colonies depends on pollen and nectar as food resources, but flowering plants are scarce in modern agricultural landscapes. It is well-known that semi-natural habitats can enhance floral resources and bumblebee abundance, but the impact of different crop types and their heterogeneity at the landsca

Behandlar premisserna för Nationalmuseums framtida verksamhet när det gäller renovering och nybyggnation på Blasieholmen.

Historical Life Course Studies, a journal in population studies, aims to stimulate and facilitate the implementation of IDS (Intermediate Data Structure, a standard data format for large historical databases), and to publish the results from (comparative) research with the help of large historical databases. The journal publishes not only empirical articles, but also descriptions (of the construct

The role of genetic variability in dementia with Lewy bodies (DLB) is now indisputable; however, data regarding copy number variation (CNV) in this disease has been lacking. Here, we used whole-genome genotyping of 1454 DLB cases and 1525 controls to assess copy number variability. We used 2 algorithms to confidently detect CNVs, performed a case-control association analysis, screened for candidat

Panic Disorder, with or without agoraphobia (PDA or PD, respectively), is a major public health problem. After having established a PD diagnosis based on the DSM or the ICD systems, the Panic Disorder Severity Scale (PDSS) is the most widely-used interview-based instrument for assessing disorder severity. There is also a self-report version of the instrument (PDSS-SR); both exist in a Swedish tran

Aim: Many species are showing distribution shifts in response to environmental change. We explored (a) the effects of inter-annual variation in winter weather conditions on non-breeding distributional abundance of waterbirds exploiting different habitats (deep-water, shallow water, farmland) and (b) the long-term shift in the population centroid of these species and investigate its link to changes

There is currently a lack of representative, systematic and harmonised greenhouse gas (GHG) observations covering the variety of natural and human-altered biomes that occur in Africa. This impedes the long-term assessment of the drivers of climate change, in addition to their impacts and feedback loops at the continental scale, but also limits our understanding of the contribution of the African c

Background: Dementia is a public health priority with a dramatic social and economic impact on people with dementia (PwD), their caregivers and societies. The aim of this study was to contribute to the knowledge on how utilization of formal and informal care varies between Sweden and Italy. Methods: Data were retrieved from two trials: TECH@HOME (Sweden) and UP-TECH (Italy). The sample consisted o

This study focuses on the role of negative-ion formation in the decay of core-valence doubly excited water molecules. Combining negative- and positive-ion coincidence measurements with calculated energies of core-valence doubly excited states, we find that O- and H- production is enhanced selectively. In particular, we suggest that O- production is correlated to double occupancy of the antibonding

Universal Design (UD) is usually stated to be “for all ages and abilities”. Given that stroke is a major source of disability, it is important that UD recommendations take stroke-specific problems into account. Within the framework of EU project STARR, we have investigated user requirements of stroke survivors. In this project we have used a mix of interviews, focus groups, design workshops and te

Importance: Prognostication of neurologic outcome after cardiac arrest is an important but challenging aspect of patient therapy management in critical care units. Objective: To determine whether serum neurofilament light chain (NFL) levels can be used for prognostication of neurologic outcome after cardiac arrest. Design, Setting and Participants: Prospective clinical biobank study of data from t

Town foundations have been at the core of urban planning since the onset of civilization. This paper describes the long-run impact of an urbanization place-based policy that was considered a failure by contemporary policymakers. We test the impact of founded towns using a series of town foundations that took place between 1570 and 1810, when the Swedish Crown conferred monopoly market rights to tr