Background: Patients with severe asthma may present with characteristics representing overlapping phenotypes, making them eligible for more than one class of biologic. Our aim was to describe the profile of adult patients with severe asthma eligible for both anti-IgE and anti-IL5/5R and to compare the effectiveness of both classes of treatment in real life. Methods: This was a prospective cohort s

Cabdio occidentalis, new species, is described from the Lake Mashkid basin and the Makran region of Iran. It is distinguished from other species of the genus by a combination of characters: 38–42+1–2 total lateral-line scales, 19–23 predorsal scales, 9–11 pectoral-fin rays, and the absence of a keel between the pelvic-fin base and the genital papilla. The cytochrome c oxidase subunit I (COI) seque

The study of atmospheric processes related to climate requires a multidisciplinary approach, encompassing physics, chemistry, meteorology, forest science, and environmental science. The Academy of Finland Centre of Excellence in atmospheric sciences (CoE ATM) responded to that need for 18 years and produced extensive research and eloquent results, which are summarized in this review. The work in t

The extent of vegetation openness in the temperate forest biome prior to modern humans is widely debated – particularly in Europe regarding baselines for conservation and restoration. The temperate forest biome was traditionally thought to be dense closed-canopy forest; however, this view has been challenged by arguments that large herbivores could have maintained some degree of openness, or even The extent of vegetation openness in past European landscapes is widely debated. In particular, the temperate forest biome has traditionally been defined as dense, closed-canopy forest; however, some argue that large herbivores maintained greater openness or even wood-pasture conditions. Here, we address this question for the Last Interglacial period (129,000–116,000 years ago), before Homo sapien

Climate change affects timing of reproduction in many bird species, but few studies have investigated its influence on annual reproductive output. Here, we assess changes in the annual production of young by female breeders in 201 populations of 104 bird species (N = 745,962 clutches) covering all continents between 1970 and 2019. Overall, average offspring production has declined in recent decade

Lifetime risk of developing breast cancer for Danish women is approx. 9%. Diagnostics are done by mammography, biopsy, and examination. Breast-conserving surgery followed by radiotherapy is standard for treatment of early-stage breast cancer. Studies report unsatisfying outcomes in up to one third of the patients. This review summarises the current surgical techniques. Oncoplastic breast surgery m

Importance: The prognostic impact of parenteral nutrition duration (PND) on retinopathy of prematurity (ROP) is not well studied. Safe prediction models can help optimize ROP screening by effectively discriminating high-risk from low-risk infants. Objective: To evaluate the prognostic value of PND on ROP; to update and validate the Digital ROP (DIGIROP) 2.0 birth into prescreen and screen predicti

This resource is a disaster risk financing conceptual framework to assist humanitarian donors, practitioners, and their partners (governments, local communities, etc.) to develop and implement more effective disaster risk financing activities.

Public health measures introduced in early 2020 to curb the spread of Covid-19 played a critical role in mitigating the worst effects of the pandemic. This column highlights how to understand the effectiveness of these policies in MENA, and the importance of evaluating the relationship between risk perception and compliance. People’s risk perception and attitudes towards the disease varied over ti

Background Effective cooperation between B-cells and T-cells within the tumor microenvironment may lead to the regression of established tumors. B-cells and T-cells can recognize tumor antigens with exquisite specificity via their receptor complexes. Nevertheless, whether a diverse intratumoral B-cells and T-cell receptor (BCR, TCR) repertoire affects the tumor immune microenvironment (TIME) and c

Oxide defects in the high-k/InGaAs MOS system are investigated. The behaviour of these traps is explored from room temperature down to 10 K. This study reveals that the exchange of free carriers between oxide states and either the conduction or the valence band is strongly temperature dependant. The capture and emission of electrons is strongly suppressed at 10 K as demonstrated by the collapse of

Objective: Late night spontaneous growth hormone (GH) pulses may influence the pituitary GH response to provocation tests. We evaluated GH response during arginine-insulin-tolerance test (AITT) after a GH peak during a short spontaneous nocturnal profile (SSNP) in children with short stature or low growth velocity. Design: Using SSNP and subsequent AITT, we examined 257 children 4–18 years old (13

Meteorological drought is a common hydrological hazard that affects human life. It is one of the significant factors leading to water and food scarcity. Early detection of drought events is necessary for sustainable agricultural and water resources management. For the catchments with scarce meteorological observatory stations, the lack of observed data is the main leading cause of unfeasible susta

An astonishing number of bat fatalities (2,371 belonging to 15 species) were recovered in a provincial surveillance program at wind farms in Cádiz, at the southern tip of Spain, in 2005–2016. We carefully analysed a subset of this sample intending to estimate the true fatality rate in the year 2011, the year for which we had the richest data set (582 fatalities at 38 wind farms). To estimate the t

Background: Several studies of distal radial fractures have investigated final displacement and its association with clinical outcomes. There is still no consensus on the importance of radiographic outcomes, and published studies have not used the same criteria for acceptable alignment. Previous reports have involved the use of linear or dichotomized analyses.Methods:The present study included 438

Great reed warblers, Acrocephalus arundinaceus,1 and great snipes, Gallinago media,2 exhibit a diel cycle in flight altitudes—flying much higher during the day than the night—when performing migratory flights covering both night and day. One hypothesis proposed to explain this behavior is that the birds face additional heating by solar radiation during daytime and hence must climb to very high, an

Frequency-domain electromagnetic induction (EMI) methods are commonly used to map vast areas quickly and with minimum logistical efforts. Unfortunately, they are often characterized by a very limited number of frequencies and severe ill-posedness. On the other hand, electrical resistivity tomography (ERT) approaches are usually considered more reliable; for example, they do not require specific ca

MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally regulate gene expression by binding to the 3' untranslated regions (UTR) of target genes. Aberrant expression of miRNAs can lead to disease, including cancer. Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Among several factors, differential expression of miRNA can have serious consequ