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Resected hippocampal tissue from patients with drug-resistant epilepsy presents a unique possibility to test novel treatment strategies directly in target tissue. The post-resection time for testing and analysis however is normally limited. Acute tissue slices allow for electrophysiological recordings typically up to 12 hours. To enable longer time to test novel treatment strategies such as, e.g.,
In this study, electrospinning has been employed to produce micro to nano scale fibres of whey protein in order to investigate their potential for use in the food industry. Initially, spinning of pure whey protein proved challenging; so in order to facilitate the spinning of freshly prepared aqueous solutions, small amounts of polyethylene oxide (as low as 1% w/w in solution) were incorporated in
Advances in sequencing technologies led to rapid increase in the number and diversity of biological sequences, which facilitated development in the sequence research. In this paper, we present a new method for analyzing protein sequence similarity. We calculated the spectral radii of 20 amino acids (AAs) and put forward a novel 2-D graphical representation of protein sequences. To characterize pro
This article takes stock of the world's largest low-carbon technology demonstration programme – the EU's NER 300. The programme has been marked by delays and many withdrawn projects since becoming operational in 2010: CCS projects have failed and not reached final investment decisions; wind and solar projects have succeeded, whereas bioenergy projects have seen successes as well as failures. These
Denna avhandling syftar till att utöka kunskapsbasen om hur grundskolelärare i Sverige kommunicerar och interagerar i sitt yrke och vilka arbetsrelaterade hälsoproblem de upplever. Avhandlingen bygger på två studier, vilka genererat tre artiklar. Papper I är baserat på resultat från en explorativ studie med fokusgruppsmetodik. I denna studie undersöktes arbetsplatskommunikationspraxis bland skolläDuring recent years, schoolteachers in Sweden have experienced many reforms and societal changes, resulting in altered conditions for work. Subsequently, many teachers have reported an increased workload and reduced well-being. In addition, previous research has identified a need for more contextually anchored measures of demands and resources pertaining to teachers’ work situation.This dissertati
While health might deteriorate through the ageing and disablement process, the impacts of disability can be reduced by adapting the environment. This study aimed to investigate the effects of applying a standardized research-based strategy to housing adaptation as compared to ordinary practice with respect to falls and fear of falling. Another aim was to investigate the overall effects of housing
Purpose: An unprecedented scale of human migration has lead humanitarians to view camps as long-term settlements rather than temporary holding facilities. The purpose of this paper is to increase the understanding of and identify challenges with this proposed new approach to camp design. Design/methodology/approach: Based on the camp design literature, the authors developed an interview guide and
Two new genera in the subfamily Teloschistoideae (Teloschistaceae, Teloschistales) are described: Hosseusiella S. Y. Kondr., L. Lőkös et A. Thell for the Caloplaca chilensis group including three South American species and Rehmanniella S. Y. Kondr. et J.-S. Hur for the new species, R. wirthii S. Y. Kondr. from South Africa. The new genera are supported by a three-gene phylogeny based on ITS1/ITS2
Nineteen new to science species of lichen forming fungi, i.e.: Agonimia ascendens S. Y. Kondr., L. Lőkös et J.-S. Hur, A. sunchonensis S. Y. Kondr. et J.-S. Hur, A. yongsangensis S. Y. Kondr. et J.-S. Hur, Biatora loekoesiana S. Y. Kondr. et J.-S. Hur, Caloplaca ivanpisutii S. Y. Kond., L. Lőkös et J.-S. Hur, Candelariella makarevichiae S. Y. Kondr., L. Lőkös et J.-S. Hur, Huriella pohangensis S.
I detta kapitel diskuteras kritiskt två relaterade tendenser i filosofiska teorier om mänskliga rättigheter. Den första handlar om synen på rättighetsinnehavaren. Mänskliga rättigheter har kommit att betraktas som något som människor ”har” och då uppstår frågan vad det är med människor som gör dem till rättighetsinnehavare. Ett vanligt svar är att människor besitter den moraliska värdighet som gör
In the article I investigate the differences between Ansel Adams' and Jerry Uelsmann's use of nature in their respective photography. Through their attitudes, approaches to, and involvement with nature their different relations to the photographic medium and the creative process unfold. Uelsmann's departure from the straight photographic tradition - that Ansel Adams came to symbolize - is in the a
In terms of genome size, the hepatitis B virus is the smallest virus known to infect humans and its compactness with multiple overlapping reading frames puts restraints on the emergence of mutations. In the papers included in this thesis we aimed to investigate genetic variation within the precore and core promoter region and to describe the origin, spread and diversification of HBV genotype A. We
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and
Novel soil remediation equipment based on electro-kinetic geosynthetics (EKG) was developed for in situ isolation of metals from paddy soil. Two mutually independent field plot experiments A and B (with and without electric current applied) were conducted. After saturation using ferric chloride (FeCl3) and calcium chloride (CaCl2), soil water drainage capacity, soil cadmium (Cd) removal performanc
Background: Labor subjects the fetus to an hypoxic episode and concomitant adrenomodullary catecholamine surge that may provide protection against the hypoxic insult. The beta1-adrenergic agonist dobutamine protects against hypoxia/aglycemia induced neuronal damage. We aimed to identify the associated protective biological processes involved. Results: Hippocampal slices from 6 days old mice showed
Background: Differences in stroke care and health outcomes between men and women are debated. The objective of this study was to explore the relationship between patients' sex and post-stroke health outcomes and received care in a Swedish setting. Methods: Patients with a registered diagnosis of acute intracerebral hemorrhage (ICH) or ischemic stroke (IS) within regional administrative systems (IC
FKBP12 (FK506 binding protein 12 kDa) is an important drug target. Nuclear magnetic resonance (NMR) order parameters, describing amplitudes of motion on the pico- to nanosecond time scale, can provide estimates of changes in conformational entropy upon ligand binding. Here we report backbone and methyl-axis order parameters of the apo and FK506-bound forms of FKBP12, based on 15N and 2H NMR relaxa
The problem of low-rank approximation with convex constraints, which appears in data analysis, system identification, model order reduction, low-order controller design and low-complexity modelling is considered. Given a matrix, the objective is to find a low-rank approximation that meets rank and convex constraints, while minimizing the distance to the matrix in the squared Frobenius norm. In man
Genom jämförelser mellan beskrivningar och bilder av landskap hos Plinius d.y., Claude Lorrain, Super Mario World och Zelda Skyward Sword undersöker jag hur en serie konventioner rörande blick, avbildande och berättande tillsammans skapar en förståelse av naturen kring oss och ut ur denna producerar ett begripligt landskap.
