Peptide mass fingerprinting of bone collagen (ZooMS) has previously been proposed as a method to calculate the extent of the non-enzymatic degradation of glutamine into glutamic acid (deamidation). Temporal and spatial variation of glutamine deamidation at a single site, however, has not been investigated. Here we apply ZooMS screening of Châtelperronian and Early Holocene bone specimens from Quin

Ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) is the enzyme responsible for the first step of carbon dioxide (CO2) fixation in plants, which proceeds via the carboxylation of ribulose 1,5-biphosphate. Because of the enormous importance of this reaction in agriculture and the environment, there is considerable interest in the mechanism of fixation of CO2 by RuBisCO. Here, a serial synch

Non-genetic variation is the phenotypic variation induced by the differential expression of a genotype in response to varying environmental cues and is broadly categorized into two types: phenotypic plasticity and developmental noise. These aspects of variation have been suggested to play an important role in adaptive evolution. However, the mechanisms by which these two types of non-genetic varia

This work reports on a method for uncertainty estimation in simulated collider-event predictions. The method is based on a Monte Carlo-veto algorithm, and extends previous work on uncertainty estimates in parton showers by including uncertainty estimates for the Lund string-fragmentation model. This method is advantageous from the perspective of simulation costs: a single ensemble of generated eve

Industrial symbiosis (IS) has been recognized as an important approach to succeed in the transition towards increased circularity in industry and society. IS involves collaboration between different actors sharing resources, aiming to minimize waste, improve resource and/or energy efficiency, resulting in reduced emissions and environmental impact. This study conducts an embedded single case study

Objectives Increasing epidemiological and experimental evidence suggests that particle exposure is an environmental risk factor for chronic kidney disease (CKD). However, only a few case-control studies have investigated this association in an occupational setting. Hence, our objective was to investigate associations between particle exposure and CKD in a large cohort of Swedish construction worke

When lab resources are shared among multiple research projects, issues such as experimental integrity, replicability, and data safety become important. Different research projects often need different software and settings that may well conflict with one another, and data collected for one project may not be safeguarded from exposure to researchers from other projects. In this paper we provide an

Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10−8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing to

This study is concerned with how contemporary Belfast riots are represented in digital culture, with a specific focus on how social resilience is discursively cultivated (or hindered) through memes about said political violence.While a substantial amount has already been written about everyday practices in post-conflict Belfast, less is known about how digital narratives represent and make sense o

Importance: Identification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies. Objective: To evaluate the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors. Design, Setting, and Participants: Individual-level analysis including data on cardiovascular

Vi testar om det går att bygga generaliserade modeller för tidsseriedata och om den framgångsrika AI-arkitekturen Transformer kan hjälpa oss med detta. Vår slutsats är att sådana modeller är möjliga, men att vi inte kan fastställa huruvida Transformer är värd mödan eller inte. Alla typer av mätningar i vilken utveckling över tid är av intresse kan porträtteras som tidsserier. Dessa är sekvenser aA reliable forward prediction of time series data is essential for optimising resource allocation, mitigating risks, and enhancing strategic decision-making across various domains. However, the limited historical data available can pose a challenge for accurate modelling. Conversely, transformer architectures, renowned for their success in natural language tasks through zero-shot inference, demons

Under den senaste tiden har det skett en betydande ökning av intresse inom forskningen och utvecklingen av arbetsflödesmotorer som är tekniska verktyg för att styra en sekvens av steg och processer. Detta har bidragit till bättre automatisering av komplexa och tidskrävande arbetsprocesser. I en del av de verksamhetssystem som Advania levererar finns det ofta ett behov av att kunna sätta upp och koIn recent times, there has been a significant increase in interest regarding the research and development of workflow engines, which are technical tools to control a sequence of steps and processes. This has enhanced the automation process of complex and time-consuming work processes. In some of the operational systems that Advania delivers, there is often a need to set up and configure different

A search for CP violation in D0→KS0K+π− and D0→KS0K−π+ decays is reported. The search is performed using an unbinned model-independent method known as the energy test that probes local CP violation in the phase space of the decays. The data analysed correspond to an integrated luminosity of 5.4 fb−1 collected in proton-proton collisions by the LHCb experiment at a centre-of-mass energy of s = 13 T

The production of ψ(2S) mesons in proton-lead collisions at a centre-of-mass energy per nucleon pair of sNN = 8.16 TeV is studied with the LHCb detector using data corresponding to an integrated luminosity of 34 nb−1. The prompt and nonprompt ψ(2S) production cross-sections and the ratio of the ψ(2S) to J/ψ cross-section are measured as a function of the meson transverse momentum and rapidity in t

BACKGROUND: Each year, more than 1.5 million people in Europe have a stroke, and many experience disabilities leading to activity and participation restrictions. Home-based rehabilitation is the recommended approach for stroke rehabilitation, in line with the international shift to integrated care. Despite this, rehabilitation often focuses on the person's physical functions, not the whole life si