Aims: To evaluate the impact of β-cell function on the efficacy of lixisenatide, a once-daily prandial glucagon-like peptide-1 receptor agonist, in patients with type 2 diabetes (T2D). Materials and methods: In this post hoc analysis, patients from the Phase 3 GetGoal-M and GetGoal-S clinical trials randomized to lixisenatide 20. μg once daily were stratified into quartiles by baseline β-cell func

A low power CMOS charge pump (CP) is proposed utilizing a new combination of charge transferring switches for a faster start-up, higher efficiency and lower reverse charge sharing. A low cost feedback mechanism observes the output voltage level and automatically switches off the clock after passing a threshold, which reduces energy dissipation by 62%. It is shown that by using one capacitor per st

With the recent advances towards modern Ion Beam Analysis (IBA), going from one- or few-parameter detector systems to multi-parameter systems, it has been necessary to expand and replace the more than twenty years old CAMAC based system. A new VME multi-parameter (presently up to 200 channels) data acquisition and control system has been developed and implemented at the Lund Ion Beam Analysis Faci

The temperature and density profiles of protoplanetary discs depend crucially on the mass fraction of micrometre-sized dust grains and on their chemical composition. A larger abundance of micrometre-sized grains leads to an overall heating of the disc, so that the water ice line moves further away from the star. An increase in the water fraction inside the disc, maintaining a fixed dust abundance,

In the design of vibration-sensitive structures, large three-dimensional numerical models are frequently used, those occasionally being too large to be simulated in a practical manner. More specifically, the analyses of vibrating complex water-pipe systems require efficient model order reduction strategies. In the paper, a numerical procedure for model order reduction of a water-pipe system housed

In this paper, I reconstruct Robert Nozick's experience machine objection to hedonism about well-being. I then explain and briefly discuss the most important recent criticisms that have been made of it. Finally, I question the conventional wisdom that the experience machine, while it neatly disposes of hedonism, poses no problem for desire-based theories of well-being.

Cancer in old age means a complex situation that may differ depending on where in the aging process the person is. For the older patient it is a reminder of that life is going to its end. Cancer treatment is to be provided in addition to handling other health problems and the overall frailty that goes with old age. Comprehensive geriatric assessment and case management may be a way to handle the f

Regional governments in Europe seem to be playing an increasing role in hydrogen and fuel cell (H2FC) development. A number of regions are supporting demonstration projects and building networks among regional stakeholders to strengthen their engagement in H2FC technology. In this article, we will analyse regions that are highly engaged in H2FC activity, based on three indicators: existing hydroge

A beam shift method is presented for an aperture coupled stacked microstrip antenna with a gridded parasitic patch. The gridded parasitic patch is formed by nine close coupled identical rectangular microstrip patches. Each of these patches is resonant at the antenna central frequency. Using four switches connecting adjacent parasitic patches in the grid, it is possible to realize a pattern reconfi

Several severe fires in structural elements, or so-called "structural fires", have occurred in Sweden in recent years. In order to study this phenomenon, a dozen fires in structural elements have been studied in a recent project. This paper provides a description of the characteristics of "structural fires" and examples of how such events can be managed and limited. Constructional fire protection,

In this work, we present a novel self-aligned gate-last fabrication process for vertical nanowire metal-oxide-semiconductor field-effect transistors. The fabrication method allows for exposure dose-defined gate lengths and a local diameter reduction of the intrinsic channel segment, while maintaining thicker highly doped access regions. Using this process, InAs nanowire transistors combining good

Investigations of past climate dynamics rely on accurate and precise chronologies of the employed climate reconstructions. The radiocarbon dating calibration curve (IntCal13) and the Greenland ice core chronology (GICC05) represent two of the most widely used chronological frameworks in paleoclimatology of the past 1/4 g50g000 years. However, comparisons of climate records anchored on these chrono

Chiral amines are important building blocks in the pharmaceutical industry, and the biocatalytic synthesis of these compounds using ω-transaminases has been increasingly studied in recent years. In principal, asymmetric synthesis of chiral amines from a prochiral ketone is the preferable route, but it is often hampered by an unfavourable equilibrium position and product inhibition. An effective me

Optimal data detection of data transmitted over a linear channel can always be implemented through the Viterbi algorithm (VA). However, in many cases of interest the memory of the channel prohibits direct application of the VA. A popular and conceptually simple method in this case, studied since the early 1970s, is to first filter the received signal in order to shorten the memory of the channel,

A quick guide to the Australian Bogong moth, the nocturnal counterpart of the migratory Monarch butterfly.

In general, diffusion rates in extractions are enhanced by increasing the temperature. In this study, we instead add compressed liquid carbon dioxide to the extraction phase to accomplish faster mass transfer. The feasibility of using carbon dioxide expanded ethanol (CXE) as the extraction phase was explored, targeting two medium-polar analytes, α-pinene and cis-verbenol in Boswellia sacra tree re

Platelets have been reported to become activated in response to bacteria and this is proposed to contribute to the acute response to bacterial infection. In the present study, we investigated platelet aggregation in response to group G streptococci (GGS) in vitro in healthy human donors and in vivo in a mouse model of streptococcal sepsis. Platelet aggregation by GGS was dependent on the bacterial

Blogs, social media, and search engines have democratized information seekers and providers. However, the same affordances of the Internet have also contributed to resurgence and transformation of far-right and racist communities. Despite a growing number of studies of far-right communities, little attention has so far been paid to the mechanisms through which far-right and racist ideologies are p