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Prediagnostic plasma testosterone, sex hormone-binding globulin, IGF-I and hepatocellular carcinoma: Etiological factors or risk markers?

Elevated prediagnostic testosterone and insulin-like growth factor I (IGF-I) concentrations have been proposed to increase risk of hepatocellular carcinoma (HCC). However, the metabolism of these hormones is altered as a consequence of liver damage and they may have clinical utility as HCC risk markers. A case-control study was nested within the European Prospective Investigation into Cancer and N

Chemical solution deposition of thin films for protonic ceramic fuel cells

Chemical solution deposition (CSD) offers the opportunity to fabricate very thin electrolyte films at lower temperatures than traditional powder-based methods. CSD methods have not been used much in production of protonic ceramic fuel cells (PCFC) until now. In this contribution we describe thin film deposition of the two proton-conducting materials BaZr0.9Y0.1O3 (-) (delta) (BZY) and La28 - xW4 +

Measurement of the transverse momentum distribution of W bosons in pp collisions at root s=7 TeV with the ATLAS detector

This paper describes a measurement of the W boson transverse momentum distribution using ATLAS pp collision data from the 2010 run of the LHC at root s = 7 TeV, corresponding to an integrated luminosity of about 31 pb(-1). Events form both W -> e nu and W -> mu nu are used, and the transverse momentum of the W candidates is measured through the energy deposition in the calorimeter from the recoil

Shades of professionalism: Risk assessment in pre‐sentence reports in Sweden

Abstract in UndeterminedAn emphasis on risk assessment has been introduced in the instructions guiding pre-sentence reports in Sweden. Since this focus indicates an organizational aspiration to risk management, we examined how pre-sentence assessments are made and especially how probation officers relate to risk assessments. Our results show that probation officers do not act in accordance with th

Impact of sequence diversity in the Moraxella catarrhalis UspA2/UspA2H head domain on vitronectin binding and antigenic variation.

The nasopharyngeal pathogen Moraxella catarrhalis recruits vitronectin to subvert complement-mediated killing. Ubiquitous surface protein (UspA) 2 and its hybrid form UspA2H bind vitronectin at the highly diverse N-terminal head domain. Here we characterized the sequence diversity of the head domain in multiple M. catarrhalis clinical isolates (n = 51) with focus on binding of vitronectin. The hea

Simultaneous growth mechanisms for Cu-seeded InP nanowires

We report on epitaxial growth of InP nanowires (NWs) from Cu seed particles by metal-organic vapor phase epitaxy (MOVPE). Vertically-aligned straight nanowires can be achieved in a limited temperature range between 340 A degrees C and 370 A degrees C as reported earlier. In this paper we present the effect of the V/III ratio on nanowire morphology, growth rate, and particle configuration at a grow

First-line panitumumab plus irinotecan/5-fluorouracil/leucovorin treatment in patients with metastatic colorectal cancer

Purpose Panitumumab monotherapy is approved for KRAS wild-type (WT) metastatic colorectal cancer (mCRC) progressing after standard chemotherapy. This study evaluated first-line panitumumab plus FOLFIRI in patients with mCRC. Methods In this phase II, single-arm study, panitumumab (6 mg/kg) and FOLFIRI [irinotecan (180 mg/m(2)) and leucovorin (400 mg/m(2)) followed by a 5-fluorouracil 400 mg/m(2) b

Trend analysis for rainfall in Delhi and Mumbai, India

Urbanisation has burdened cities with many problems associated with growth and the physical environment. Some of the urban locations in India are becoming increasingly vulnerable to natural hazards related to precipitation and flooding. Thus it becomes increasingly important to study the characteristics of these events and their physical explanation. This work studies rainfall trends in Delhi and

Tool wear and tool life of PCBN, binderless cBN and wBN-cBN tools in continuous finish hard turning of cold work tool steel

The paper presents the results of comparative study of performance of cutting tools made of ceramic-bound, binderless cBN, and wBN-cBN tool materials. The tool performance was assessed by tool wear-resistance, values of cutting forces, parameters of machined surface quality, and the state of sub-surface layer generated in continuous turning of hardened cold work tool steel. The tests were carried

Evolution of reproductive strategies in libellulid dragonflies (Odonata: Anisoptera)

In Libellulidae, oocyte production has been assumed to be continuous, with periods of egg-laying interspersed with periods of resting/eating; however, recent work suggests that two types of oocyte production are common: either (a) continuous or (b) step-wise. These are mirrored in the arrangement of the ovarioles in the ovaries. Likewise, two types of mate-guarding behavior have been observed in L

Low anthropometric measures and mortality-results from the Malmo Diet and Cancer Study

Aim. To study the association between anthropometric measures: body mass index (BMI), percent body fat, waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), waist-to-hip-to-height ratio (WHHR), and A Body Shape Index (ABSI); to see if individuals in the lowest 5 percentiles for these measures have an increased risk of mortality. Methods. A population-based prospective

Mortality in persons with mental disorders is substantially overestimated using inpatient psychiatric diagnoses

Mental disorders are associated with premature mortality, and the magnitudes of risk have commonly been estimated using hospital data. However, psychiatric patients who are hospitalized have more severe illness and do not adequately represent mental disorders in the general population. We conducted a national cohort study using outpatient and inpatient diagnoses for the entire Swedish adult popula

Inhibition of metastasis in a castration resistant prostate cancer model by the quinoline-3-carboxamide tasquinimod (ABR-215050)

BACKGROUND Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that has completed phase II clinical trial in patients with castration resistant prostate cancer, showing promising inhibiting effects on the occurrence of metastasis and delayed disease progression. Its mechanism of action is not fully elucidated, but previous studies show anti-angiogenic effects and strong int

Authoritarian regime types revisited: updated data in comparative perspective

This article introduces a modified and updated version of the authoritarian regime type dataset first introduced by Hadenius and Teorell [2007. Pathways from authoritarianism. Journal of Democracy, 18 (1), 143–157]. The basic logic and merits of this dataset is presented, previously published criticism of the index is addressed and practical advice for potential users is provided. The dataset is a

Stromal Activation Associated with Development of Prostate Cancer in Prostate-Targeted Fibroblast Growth Factor 8b Transgenic Mice

Expression of fibroblast growth factor 8 (FGF-8) is commonly increased in prostate cancer. Experimental studies have provided evidence that it plays a role in prostate tumorigenesis and tumor progression. To study how increased FGF-8 affects the prostate, we generated and analyzed transgenic (TG) mice expressing FGF-8b under the probasin promoter that targets expression to prostate epithelium. Pro

Super Resolution Laser Radar with Blinking Atmospheric Particles - Application to Interacting Flying Insects

Assessment of biodiversity of pollinators on the landscape scale or estimation of fluxes of disease-transmitting biting midges constitutes a major technical challenge today. We have developed a laser-radar system for field entomology based on the so called Scheimpflug principle and a continuouswave laser. The sample-rate of this method is unconstrained by the round-trip time of the light, and the

Transfer into L3 English : Global accent in German-dominant heritage speakers of Turkish

This study is concerned with L3 acquisition in heritage speakers (HSs). The goals are to incorporate HSs into L3 acquisition research and investigate the role of language dominance for predicting L3 transfer. We analyze global accent in German-Turkish early bilinguals, HSs of Turkish, who acquired English as their L3. Twenty native-speaker judges determined accent strength and accent source in the

Enzymatic Activity of Lipase-Nanoparticle Conjugates and the Digestion of Lipid Liquid Crystalline Assemblies

Variants of lipase were attached to gold nanoparticles (NPs) and their enzymatic activity was studied. The two bioengineered lipase variants have been prepared with biotin groups attached to different residues on the protein outer surface. The biotinylation was evidenced by denaturing polyacrylamide gel electrophoresis and quantified by the ([2-(4'-hydroxyazobenzene)]benzoic acid spectrophotometri

The influence of crystalline lens accommodation on post-saccadic oscillations in pupil-based eye trackers

It is well known that the crystalline lens (henceforth lens) can oscillate (or 'wobble') relative to the eyeball at the end of saccades. Recent research has proposed that such wobbling of the lens is a source of post-saccadic oscillations (PSOs) seen in data recorded by eye trackers that estimate gaze direction from the location of the pupil. Since the size of the lens wobbles increases with accom