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Appraisals of Wildlife During Restorative Opportunities in Local Natural Settings

Many call for a broad approach to valuation of nature’s contribution to people, one that provides a contextualized understanding of what may be experienced as a value in different cultures, groups and settings. In the present paper we address contributions of nature to psychological well-being as realized through restorative processes during encounters with wildlife. Although restorative benefits

Adolescents’ experiences of facilitators for and barriers to maintaining exercise 12 months after a group-based intervention for depression

Exercise can improve health among adolescents with depression. Understanding facilitators for and barriers to maintaining exercise among adolescents with depression may increase adherence to exercise and consequently improve health. The aim was to explore adolescents’ experiences of facilitators for and barriers to maintaining exercise after a group-based exercise intervention for depression. Inte

Exploring factors associated with research involvement of undergraduate students at the College of Medicine and Health Sciences, University of Rwanda

Background: Early involvement of students in research processes is an important step in professional development and can increase the academic output of the university. Previous studies indicate low research involvement amongst undergraduate students, however limited research has been done in sub-Saharan Africa. This study aimed to describe the level of research involvement amongst undergraduate s

Development of a surgical competency assessment tool for sentinel lymph node dissection by minimally invasive surgery for endometrial cancer

Sentinel lymph node dissection is widely used in the staging of endometrial cancer. Variation in surgical techniques potentially impacts diagnostic accuracy and oncologic outcomes, and poses barriers to the comparison of outcomes across institutions or clinical trial sites. Standardization of surgical technique and surgical quality assessment tools are critical to the conduct of clinical trials. B

Acute manic state with psychotic features in a teenager with autoimmune encephalitis

INTRODUCTION: Autoimmune disorders have become increasingly acknowledged as having a more causative role in encephalitis than previously assumed. Anti-N-methyl-D-aspartate receptor encephalitis seems to be the most prevalent disorder. Symptoms of the neuropsychiatric phase in children and adolescents include abnormal behavior, seizures, and neurologic symptoms. We present a report on a teenage gir

Hypnosis Intervention for Sleep Disturbance : Determination of Optimal Dose and Method of Delivery for Postmenopausal Women

Sleep disturbances are a pervasive problem among postmenopausal women, with an estimated 40 to 64% reporting poor sleep. Hypnosis is a promising intervention for sleep disturbances. This study examined optimal dose and delivery for a manualized hypnosis intervention to improve sleep. Ninety postmenopausal women with poor sleep were randomized to 1 of 4 interventions: 5 in-person, 3 in-person, 5 ph

The Aurora kinase/β-catenin axis contributes to dexamethasone resistance in leukemia

Glucocorticoids, such as dexamethasone and prednisolone, are widely used in cancer treatment. Different hematological malignancies respond differently to this treatment which, as could be expected, correlates with treatment outcome. In this study, we have used a glucocorticoid-induced gene signature to develop a deep learning model that can predict dexamethasone sensitivity. By combining gene expr

An Open Source, Automated Tumor Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer

Purpose: Although tumor infiltrating lymphocytes (TIL) assessment has been acknowledged to have both prognostic and predictive importance in triple negative breast cancer (TNBC), it is subject to inter and intra-observer variability that has prevented widespread adoption. Here we constructed a machine-learning based breast cancer TIL scoring approach and validated its prognostic potential in multi

Older people’s strategies for meaningful social interactions in the context of eldercare services

Considering that ‘social work with older people’ refers to something that is carried out with older people, it is of crucial importance to reveal the meaning of ‘the social’ from the perspective of the elderly. The aim of this article is to reveal how older people go about achieving meaningful social interactions in everyday life in the context of eldercare services and the role of social work pra

Authentic and posed emotional vocalizations trigger distinct facial responses

The ability to recognize the emotions of others is a crucial skill. In the visual modality, sensorimotor mechanisms provide an important route for emotion recognition. Perceiving facial expressions often evokes activity in facial muscles and in motor and somatosensory systems, and this activity relates to performance in emotion tasks. It remains unclear whether and how similar mechanisms extend to

Dietary Data in the Malmö Offspring Study : Reproducibility, Method Comparison and Validation against Objective Biomarkers

Irregular dietary intakes impairs estimations from food records. Biomarkers and method combinations can be used to improve estimates. Our aim was to examine reproducibility from two assessment methods, compare them, and validate intakes against objective biomarkers. We used the Malmö Offspring Study (55% women, 18-71 y) with data from a 4-day food record (4DFR) and a short food frequency questionn

Mutational profile of ZBTB16-RARA-positive acute myeloid leukemia

Background: The ZBTB16-RARA fusion gene, resulting from the reciprocal translocation between ZBTB16 on chromosome 11 and RARA genes on chromosome 17 [t(11;17)(q23;q21)], is rarely observed in acute myeloid leukemia (AML), and accounts for about 1% of retinoic acid receptor-α (RARA) rearrangements. AML with this rare translocation shows unusual bone marrow (BM) morphology, with intermediate aspects

Epidemiology and Etiology of AML

Acute myeloid leukemia (AML) is a grave disease with an incidence of 4 per 100,000 a year. It can present in all ages, but the median age is 70 years. One-third of such patients have secondary AML, that is, AML following chemoradiotherapy or a transformation from previous myelodysplastic syndrome (MDS) or myeloproliferative neoplasia. A combination of genetic, epigenetic, and environmental factors