Several threads of research towards developing artificial gametes are ongoing in a number of research labs worldwide. The development of a technology that could generate gametes in vitro has significant potential for human reproduction, and raises a lot of interest, as evidenced by the frequent and extensive media coverage of research in this area. We have asked researchers involved in work with a

In this paper, we explore the ethical and legal implications of a hypothetical use of artificial gametes (AGs): that of taking a person’s cells, converting them to artificial gametes and using them in reproduction – without that person’s knowledge or consent. We note the common reliance on genetic understandings of parenthood in the law, and suggest that injustices may arise if unwitting genetic p

This book examines, through a multi-disciplinary lens, the possibilities offered by relationships and family forms that challenge the nuclear family ideal, and some of the arguments that recommend or disqualify these as legitimate units in our societies. That children should be conceived naturally, born to and raised by their two young, heterosexual, married to each other, genetic parents; that th

Phase retrieval approaches based on deep learning (DL) provide a framework to obtain phase information from an intensity hologram or diffraction pattern in a robust manner and in real-time. However, current DL architectures applied to the phase problem rely on i) paired datasets, i. e., they are only applicable when a satisfactory solution of the phase problem has been found, and ii) the fact that

Objective: Monoclonal gammopathy of undetermined significance (MGUS) is the asymptomatic precursor of multiple myeloma (MM). Lytic bone lesions and fractures are hallmarks of MM and although there are no lytic lesions in MGUS, it has also been associated with fractures. The causes of fractures in MGUS are currently unclear but potential causes include inherent MGUS bone disease, undiagnosed MM, an

Pluvial flood damage to residential buildings causes a significant part of direct tangible flood losses. In this study, we investigate the non-hazard variables and sewer system types in relation to damage costs in the city of Malmö, Sweden. A comprehensive data set of around 1000 records of direct damage to residential buildings from a cloudburst event on 31 August 2014 in Malmö, Sweden has been a

Swedish has been generally assumed not to have any well-defined question intonation. However, with respect to Southern Swedish, Lindblad & Gårding (1973) present data showing final rises in polar (Y/N) questions. Gårding (1979) also assumes a broader and higher F0 range in Y/N questions than in statements, particularly on the final focussed word. The present study investigates the extent to wh

This new edition includes a greater focus on applicable ISO standards in facility management as well as maintaining an international perspective throughout. It covers: the fundamentals of facility management, including key roles, responsibilities and accountabilities and the core competencies of facility management; an exploration of facility planning, facility management strategy, outsourcing, pr

As a growing number of diplomatic practices take new digital forms, research on digital diplomacy is rapidly expanding. Many of the changes linked to digitalization transform or challenge traditional ways of doing diplomacy. Analyses of new forms of “digital diplomacy” are therefore valuable for the advancement of practice approaches in international relations theory. That said, digital diplomacy

Postural orthostatic tachycardia syndrome (POTS) is a chronic and often disabling disorder characterized by orthostatic intolerance with excessive heart rate increase without hypotension during upright posture. Patients often experience a constellation of other typical symptoms including fatigue, exercise intolerance and gastrointestinal distress. A typical patient with POTS is a female of child-b

This chapter reports preliminary findings from a study of epistemic consequences of misinformation in social networks. It uses the methodology of computer simulation, constructing computer models of Bayesian learning in networks that include untrustworthy sources. Censorship and de-platforming take time and money, and they violate social and democratic norms of inclusiveness and free speech. Enqui

BACKGROUND: Surgical safety during posterior sagittal anorectal plasty (PSARP) for anorectal malformations (ARM) depends on accurate pre-operative fistula localization. This study aimed to evaluate accuracy of pre-operative fistula diagnostics.METHODS: Ethical approval was obtained. Diagnostic accuracy of pre-PSARP symptoms (stool in urine, urine in passive ostomy, urinary tract infection) and exa