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Mitochondrial permeability transition in acute neurodegeneration.

Acute neurodegeneration in man is encountered during and following stroke, transient cardiac arrest, brain trauma, insulin-induced hypoglycemia and status epilepticus. All these severe clinical conditions are characterized by neuronal calcium overload, aberrant cell signaling, generation of free radicals and elevation of cellular free fatty acids, conditions that favor activation of the mitochondr

Observation of states beyond band termination in Er-156,Er-157,Er-158 and strongly deformed structures in Hf-173,Hf-174,Hf-175

High-spin terminating bands in heavy nuclei were first identified in nuclei around Er-158(90). While examples of terminating states have been identified in a number of erbium isotopes, almost nothing is known about the states lying beyond band termination. In the present work, the high-spin structure of Er-156,Er-157,Er-158 has been studied using the Gammasphere spectrometer. The subject of triaxi

Integrated analysis of conditions accounting for intersite distribution of grassland plants

The objectives are to relate species distributions among 110 non-fertilized grassland ('dry meadow') sites in southeastern Sweden to soil chemical, physical, exposure and management variables using correlation, stepwise regression and factor (PCA) analysis based on quantitative data. It was suggested that soil acidity variables (pH, base saturation, exchangeable Ca, Al, Mn,and Fe), P, K, Mg, and N

Industrial biotechnology for the production of bio-based chemicals - a cradle-to-grave perspective

Shifting the resource base for chemical production from fossil feedstocks to renewable raw materials provides exciting possibilities for the use of industrial biotechnology-based process tools. This review gives an indication of the current developments in the transition to bio-based production, with a focus on the production of chemicals, and points out some of the challenges that exist in the la

System size and energy dependence of jet-induced hadron pair correlation shapes in Cu+Cu and Au+Au collisions at root S-NN 200 and 62.4 GeV

We present azimuthal angle correlations of intermediate transverse momentum (1-4 GeV/c) hadrons from dijets in Cu+Cu and Au+Au collisions at root s(NN)=62.4 and 200 GeV. The away-side dijet induced azimuthal correlation is broadened, non-Gaussian, and peaked away from Delta phi=pi in central and semicentral collisions in all the systems. The broadening and peak location are found to depend upon th

Relative importance of burning, mowing and species translocation in the restoration of a former boreal hayfield: responses of plant diversity and the microbial community

1. The extensive loss of species-rich grasslands in Europe as a result of agricultural intensification has triggered a desire to recreate more diverse and natural grassland systems in set-aside fields. Appropriate management and species introductions are necessary to overcome residual soil fertility, lack of suitable plant propagules and dominance of undesirable invasive species. 2. A field experi

Effects of anti-secretory factor (ASF) on irritable bowel syndrome (IBS)

Objective. To evaluate the role of the endogenous protein anti-secretory factor (ASF) on the symptoms, especially loose stools, in irritable bowel ayndrome (IBS). Design. A diet with specially processed cereals (SPC) known to induce ASF production was used in patients with IBS, in an eight-week randomized, placebo-controlled study. Subjects. Eighty-two patients with IBS were randomized to a diet w

Neutrophil cannibalism--a back up when the macrophage clearance system is insufficient.

Background: During a lipopolysaccharide-induced lung inflammation, a massive accumulation of neutrophils occurs, which is normally cleared by macrophage phagocytosis following neutrophil apoptosis. However, in cases of extensive apoptosis the normal clearance system may fail, resulting in extensive neutrophil secondary necrosis. The aim of this study was to explore the hypothesis that neutrophils,

Routes to Equity Market Integration – the interplay between Politicians, Investors and Managers

Most econometric studies of equity market integration suggest that national markets are increasingly becoming part of a global equity market. As regards the extent of this integration, however, the results are often inconclusive. Further analysis calls for a closer scrutiny of the basic requirements for perfect integration. This paper presents an analysis of market segmentation in terms of existin

UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors.

Mitogenic effects of the extracellular nucleotides ATP and UTP are mediated by P2Y(1), P2Y(2), and P2Y(4) receptors. However, it has not been possible to examine the highly expressed UDP-sensitive P2Y(6) receptor because of the lack of stable, selective agonists. In rat aorta smooth muscle cells (vascular smooth muscle cells; VSMC), UDP and UTP stimulated (3)H-labeled thymidine incorporation with

A palaeomagnetic and Ar-40/Ar-39 study of late precambrian sills in the SW part of the Amazonian craton: Amazonia in the Rodinia reconstruction

A new key palaeomagnetic pole (Plat. = 64.3 degrees S, Plon. = 271.0 degrees E, N = 14, A(95) = 9.2 degrees; Q = 5) is calculated from a primary magnetization isolated in early Neoproterozoic Aguapei basic sills and dykes hosted by 1.3-1.0 Ga sedimentary rocks from the southwestern part of the Amazon craton. The characteristic remanence carried by stable, pseudo-single domain titanomagnetite shows

Histologic reactions to particulate wear debris in different mesenchymal tissues - Studies on the nonreplaced compartment from revised uni-knees

The interface between bone and artificial-joint implants consists of soft tissue. This tissue varies from fibrocartilage to loose fibrous tissue. Tissues that resemble those can be found in normal joints. Sixteen knees with unicompartmental knee prostheses, revised because of excessive wear of the tibial insert, were studied. Synovium, synovial fluid, cartilage, and bone from the nonreplaced compa

From synergy to symbiosis: new directions in security and privacy?

The objective of this article reflects upon the isomorphic relationship between ideas across disciplines. In this instance we are considering the value of a well established methodology, cross methodology, adopted from macroeconomics and ideas from political science. The cross methodology is used as a means of considering the relationship between data collected for security purposes and individual

A long-term record of Quercus decline, logging and fires in a southern Swedish Fagus-Picea forest

We reconstructed forest development and disturbance events (fire and logging) during the last 1000 yr with tree-ring data, pollen and charcoal analysis from a semi-natural Fagus sylvatica-Picea abies forest (ca. I km(2)) in the hemiboreal zone. According to pollen analysis, Quercus robur together with Pinus sylvestris was abundant in the forest until the turn of the 18th/19th centuries when these