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Performance of a pressure-based unstructured code and a multi-block structured code for heat transfer and fluid flow

This paper reports a multi-block unstructured method for incompressible flows and the performance comparison with a multi-block structured method. The unstructured collocated grid is composed of arbitrary cell shapes. Pressure and velocity are stored at cell centres; Rhie and Chow interpolation is used to prevent checker boarding. The SIMPLE algorithm is used for pressure-velocity coupling. The co

Flow-through picoliter dispenser: A new approach for solvent elimination in FT-IR spectroscopy

A new interface for FT-IR analysis of liquid samples on the basis of solvent elimination is presented. The approach is based on a piezoactuated flow-through microdispenser, a device built of two microstructured silicon wafers designed for micro-liquid handling. It could be verified during preliminary studies using a sequential injection (SI) system for automated liquid handling that the flow-throu

Long term depression of human nociceptive skin senses induced by thin fibre stimulation.

We have recently shown that stimulation, through a multi-electrode array, of thin nerve fibres close to the dermo-epidermal junction in the skin, produces powerful inhibition of itch and, to a lesser degree, cutaneous pain in humans. Here, we have studied the induction time and frequency dependency (range 1–10 Hz) of the inhibitory effects of such stimulation on itch, mechanical, and thermal pain,

The bactericidal/permeability-increasing protein (BPI) is present in specific granules of human eosinophils

Eosinophils participate in the inflammatory response seen in allergy and parasitic infestation, but a role in host defense against bacterial infection is not settled. The bactericidal/permeability-increasing protein (BPI) has been demonstrated in neutrophils and it exerts bacteriostatic and bactericidal effects against a wide variety of Gram-negative bacterial species. Using the Western blot techn

Non-Invasive Assessment of the Atrial Cycle Length during Atrial Fibrillation in Man: Introducing, Validating and Illustrating a New ECG Method

OBJECTIVES: Atrial fibrillation (AF) in man has previously been shown to include a wide variety of atrial activity. Assessment of the characteristics of this arrhythmia with a commonly applicable tool may therefore be important in the choice and evaluation of different therapeutic strategies. As the AF cycle length has been shown to correlate locally with atrial refractoriness and globally with th

Diabetes-associated HLA genotypes affect birthweight in the general population.

Aims/hypothesisThe aim of our study was to test the hypothesis that HLA genotypes conferring risk of diabetes, cord blood autoantibodies, or both are associated with increased birthweight. Methods: HLA genotypes were determined in dried blood spots of cord blood from a total of 16,709 children born to healthy mothers in the Diabetes Prediction in Skane (DiPiS) study, a population-based observation

Effects of nutrition on sexual ornaments and humoral immune responsiveness in adult male pheasants

Female pheasants may base their choice of mates on the expression of male ornaments such as the red chin wattle and the length of the spurs. Both these ornaments are predicted to be sensitive to access to carotenoids (and vitamins). Moreover, because carotenoids also enhance immune function, it has been suggested that there is a trade-off in the use of carotenoids for ornament expression and immun

Focused ion beam fabrication of novel core-shell nanowire structures

A novel method of indirect deposition by means of a focused ion beam (FIB) is utilized to develop metal/insulator/semiconductor nanowire core-shell structures. This method is based upon depositing an annular pattern centered on a nanowire, with secondary deposition then coating the wire. Typical cross-sectional deposition area increments as a function of ion doses are 1.3 x 10(-2) mu m(2) nC(-1) f

Resilience of a zooplankton community subjected to marine intrusion in a tropical coastal lagoon

One of the main disturbances on Imboassica Lagoon is the occasional artificial opening of its sand bar. Following two such events, two environmental gradients were observed. One was directly related to entry of marine water ( salinity gradient); and the other to a decrease in dilution of the nutrient load, because of water level reduction ( trophic status gradient). Two stations were sampled. At S

Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes

There is considerable interest in understanding how cis-regulatory modifications drive morphological changes across species. Because developmental regulatory genes, including Hox genes, are remarkably conserved, their noncoding regulatory regions are likely sources for variations. Modifications of Hox cis-regulatory elements have potential to alter Hox gene expression and, hence, axial morphologie

A systems perspective of slip and fall accidents on ice and snow

Current research on slips and falls has mainly focused on floors and/or contaminated floors. Although icy and snowy surfaces near melting temperature are more slippery, more important still, slip and falls on icy and snowy surfaces involve not only outdoor workers, but also pedestrians and the general public; and occur in cold regions and in the winter season in many parts of the world. However, i

Laser-wakefield acceleration of monoenergetic electron beams in the first plasma-wave period

Beam profile measurements of laser-wakefield accelerated electron bunches reveal that in the monoenergetic regime the electrons are injected and accelerated at the back of the first period of the plasma wave. With pulse durations c tau >=lambda(p), we observe an elliptical beam profile with the axis of the ellipse parallel to the axis of the laser polarization. This increase in divergence in the l

Internal stresses in glulam due to moisture gradients in the grain direction

An experimental study on the internal stress state perpendicular to grain in glued laminated timber induced by moisture variations along the grain is presented. The stress is evaluated by using measured modulus of elasticity and strain. Different types of tests are performed, in which specimens are exposed to artificial climate change when the specimens are in either a wetting or a drying state, a

Consequences of a ligament injury on neuromuscular function and relevance to rehabilitation - using the anterior cruciate ligament-injured knee as model.

The purpose of this article is to survey current knowledge concerning the consequences of a ligament injury on neuromuscular function and its relevance to rehabilitation, in relation to clinical practice. Although it deals with the ACL-injured knee, these views may also apply to other joints. The effects of a ligament injury on neuromuscular function are first considered - i.e., proprioception, po

Alpha10 integrin expression is up-regulated on fibroblast growth factor-2-treated mesenchymal stem cells with improved chondrogenic differentiation potential.

Mesenchymal stem cells (MSCs) are multipotent cells that have the capacity to differentiate into various different cell lineages and can generate bone, cartilage and adipose tissue. MSCs are presently characterized using a broad range of different cell-surface markers that are not exclusive to MSCs and not sensitive to culture conditions or differentiation capacity. We show that the integrin subun

A wavelet based R-wave detector for cardiac pacemakers in 0.35 CMOS technology

This paper presents a wavelet based event detector for cardiac pacemakers implemented in 0.35μm CMOS technology. The architecture is optimized by wordlength and strength reduction resulting in a total chip area of 2.2mm 2. Detector performance is studied by means of databases containing electrograms as well as different types of noise and interferences, which are added to the signals. T

Clonal structure and genet-level sex ratios suggest different roles of vegetative and sexual reproduction in the clonal moss Hylocomium splendens

The allozyme haplotype was determined for 157 ramets of the unisexual, perennial, clonal moss Hylocomium splendens within five 10×10 cm plots, which had been the subject of demographic studies over a 5-yr period. In addition, 25 shoots were analyzed from outside the plots and from four neighbouring patches. Only four haplotypes were encountered within the plots; one female type occurred in all plo