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GenetIC - A new initial conditions generator to support genetically modified zoom simulations

We present genetIC, a new code for generating initial conditions for cosmological N-body simulations. The code allows precise, user-specified alterations to be made to arbitrary regions of the simulation (while maintaining consistency with the statistical ensemble). These "genetic modifications"allow, for example, the history, mass, or environment of a target halo to be altered in order to study t

Zoom-in array comparative genomic hybridization (aCGH) to detect germline rearrangements in cancer susceptibility genes.

Disease predisposing germline mutations in cancer susceptibility genes may consist of large genomic rearrangements, including deletions or duplications that are challenging, to detect and characterize using standard PCR-based mutation screening methods. Such rearrangements range from single exons up to hundreds of kilobases of sequence in size. Array-based comparative genomic hybridization (aCGH)