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Popular Abstract in Swedish Cancer är den ledande dödsorsaken i världen och stod för 7,6 miljoner dödsfall under 2008, vilket beräknas vara omkring 13 % av den totala dödsfallsiffran. Även om det finns flera olika metoder för att behandla eller bromsa cancerutveckling, krävs det nya terapier på grund av allvarliga biverkningar och otillfredsställande resultat med de nuvarande behandlingsmetoderna.Proteoglycans (PG) are highly anionic macromolecules consisting of a core protein covalently substituted with long unbranched polysaccharide chains called glycosaminoglycans (GAGs). PGs are central components in multicellular organisms, and they may occur in the extracellular matrix (ECM), at the cell surface, or in the secretory pathway. At the tumor cell surface, PGs and GAGs are involved in the

Unemployment swings have distributional consequences if some groups are hit harder than others. We examine if the sensitivity to local unemployment rates varies by characteristics such as health, cognitive ability and non-cognitive ability. Data on these variables come from registers covering the entire Swedish population of males. We show that variations in the unemployment rate are associated wi

Placodium umbrinum Breuss is reported as new to northern Europe from the island of Gotland, Sweden. The species is described and depicted, and its ecology at the locality on Gotland is given. A key is given for former members of the genus Catapyrenium growing on soil, mosses or bark in the Nordic countries.

Floor adhesives on cement-based substrates may degrade if the pH is high enough and this has in many cases led to emissions of odorous substances and deteriorated indoor air quality. We have used isothermal calorimetry to assess the degradation rate of two floor adhesives as a function of pH. The rate of heat production measured by the calorimeter is proportional to the reaction rate. The degradat

A simple and easy-to-use extraction method for aqueous samples based on hollow fibre-supported liquid membrane (HF-SLM) followed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) was developed to determine ivermectin and transformation products, the monosaccharide (TP1) and the aglycon of ivermectin (TP2). The proposed method attained enrichment factors up to 80, after optimi

Popular Abstract in English In the modern world of today, we are surrounded with many electronic devices which offer previously unseen performance. These devices constitute a large part of the everyday consumer electronics such as laptops, tablets, smart phones, etc., but are also used in wide variety of domains such as automotive industry, avionics, medicine, etc. The constant demand for high perIncreasing soft error rates in recent semiconductor technologies enforce the usage of fault tolerance. While fault tolerance enables correct operation in the presence of soft errors, it usually introduces a time overhead. The time overhead is particularly important for a group of computer systems referred to as real-time systems (RTSs) where correct operation is defined as producing the correct re

Abstract in UndeterminedIt has recently been argued that giving is spontaneous while greed is calculated (Rand et al. 2012). If greed is calculated we would expect that cognitive load, which is assumed to reduce the influence of cognitive processes, should affect greed. In this paper we study both charitable giving and the behavior of dictators under high and low cognitive load, to test if greed i

MuA transposase protein is a member of the retroviral integrase superfamily (RISF). It catalyzes DNA cleavage and joining reactions via an initial assembly and subsequent structural transitions of a protein-DNA complex, known as the Mu transpososome, ultimately attaching transposon DNA to non-specific target DNA. The transpososome functions as a molecular DNA-modifying machine and has been used in

Popular Abstract in Swedish Receptbelagda lugnande läkemedel används i behandling av framför allt ångest och sömnbesvär och har i det sammanhanget stor betydelse. Dessvärre kan beroende av dessa läkemedel utvecklas. Det förekommer även så kallad felanvändning av dessa läkemedel, d.v.s. användning utan recept, eller i högre doser, mer ofta, eller för annat syfte, än vad läkare har ordinerat. Sådan Background: Prescription sedatives are efficient in the treatment of anxiety and sleeping disorders, but are associated with a risk of misuse and dependence, as well as an increased risk of accidents, injuries and overdoses, both in the general population and especially in individuals with other substance misuse. The present thesis aims to investigate prescription sedative use and misuse in two ki

We investigate the time periodic solutions to the viscous Burgers equation $u_t -mu u_{xx} + uu_x = f$ for irregular forcing terms. We prove that the corresponding Burgers operator is a diffeomorphism between appropriate function spaces.

Med nya metoder som fältflödesfraktionering kan effekter av tillverkning och tillagning på lösliga kostfibers egenskaper följas. Genom att mäta genuttryck i blodkroppar efter en måltid kan man också få kunskap om fibrernas påverkan på ämnesomsättningen i kliniska studier.

Popular Abstract in Swedish Under de senaste årtiondena har prestandan i elektriska kretsar växt i en rasande takt. Detta har lett till otaliga innovationer som har förbättrat samhället. Grunden till denna utveckling grundar sig i två uppfinningar: transistorn och den integrerade kresten. Till skillnad från många andra grundläggande elektroniska komponenter har en transistor tre elektroder. En eRecent decades have seen an exponential increase in the functionality of electronic circuits, allowing for continuous innovation, which benefits society. This increase in functionality has been facilitated by scaling down the dimensions of the most important electronic component in modern electronics: the Si-based MOSFET. By reducing the size of the device, more transistors per chip area is possib

In mesoscopic and nanoscale systems at low temperatures, charge carriers are typically not in thermal equilibrium with the surrounding lattice. The resulting, non-equilibrium dynamics of electrons has only begun to be explored. Experimentally the time-dependence of the electron temperature (deviating from the lattice temperature) has been investigated in small metallic islands. Motivated by these

Evidence from clinical studies and animal models show that inflammation can lead to the development of depression. Macrophage migration inhibitory factor (MIF) is an important multifunctional cytokine that is synthesized by several cell types in the brain. MIF can increase production of other cytokines, activates cyclooxygenase (COX)-2 and can counter-regulate anti-inflammatory effects of glucocor

Whereas the language development of children with sensorineural hearing impairment (SNHI) has repeatedly been shown to differ from that of peers with normal hearing (NH), few studies have used an experimental approach to investigate the consequences on everyday communicative interaction. This mini review gives an overview of a range of studies on children with SNHI and NH exploring intra- and inte

Abstract in UndeterminedNuclear quadrupole resonance (NQR) is a non-invasiveradio-frequency technique allowing for a practically unique%ngerprint for molecules containing quadrupolar nuclei,making the technique very promising for detection purposes.If properly excited, these nuclei will emit electromagnetic radiation,the frequency of which is governed mainly by wherein the molecule the nuclei are

Combination therapies with inhaled corticosteroids (ICS) and either long-acting ß2 agonists (LABA) or leukotriene receptor antagonists (LTRA) are commonly used to help patients maintain control of their asthma. LABA and LTRA have different mechanisms of action and both provide complementary benefits when combined with ICS. This paper compares the two regimens based on recent clinical trial data, e

The transmembrane topology of the Acr3 family arsenite transporter Acr3 from Bacillus subtilis was analysed experimentally using translational fusions with alkaline phosphatase and green fluorescent protein and in silico by topology modelling. Initial topology prediction resulted in two models with 9 and 10 TM helices respectively. 32 fusion constructs were made between truncated forms of acr3 and