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Hematopoietic age at onset of triple-negative breast cancer dictates disease aggressiveness and progression

Triple-negative breast cancer (TNBC) is considered an early onset subtype of breast cancer that carries with it a poorer prognosis in young rather than older women for reasons that remain poorly understood. Hematopoiesis in the bone marrow becomes altered with age and may therefore affect the composition of tumor-infiltrating hematopoietic cells and subsequent tumor progression. In this study, we

Leadership as Social Integrative Action. A Study of a Computer Consultancy CompanyLeadership as social integrative action

In this paper it is suggested that leadership, at least in some types of organiza tions, can be conceptualized as social integrative action. Such action is seen as a synthesis of institutional and human relations-oriented leadership. A case study of a computer consultancy company, a professional service adhocracy, supports this argument. This paper also argues for viewing leadership as an expressi

Comparison of heat transfer characteristics of aviation kerosene flowing in smooth and enhanced mini tubes at supercritical pressures

Purpose - The purpose of this paper is to numerically investigate the heat transfer performance of aviation kerosene flowing in smooth and enhanced tubes with asymmetric fins at supercritical pressures and to reveal the effects of several key parameters, such as mass flow rate, heat flux, pressure and inlet temperature on the heat transfer. Design/methodology/approach - A CFD approach is taken and

Ninety-one species of lichens and allied fungi new to Latvia with a list of additional records from Kurzeme

The results of lichenological excursions of the 19th Symposium of Baltic Mycologists and Lichenologists (BMLS) in Latvia, Kurzeme region, 22–26 September 2014, are reported. A list of 290 species is presented, of which 238 are lichenized, 43 lichen-inhabiting, and nine saprotrophic fungi: ninety-one species are new to Latvia, twelve of which (Caloplaca duplicata, Cresporhaphis wienkampii, Ellisemb

Development of a Scheimpflug Lidar System for Atmospheric Aerosol Monitoring

This work presents a Scheimpflug lidar system which was employed for atmospheric aerosol monitoring in southern Sweden. Atmospheric aerosol fluctuation was observed around rush-hour. The extinction coefficient over 6 km was retrieved, i.e., 0.15 km-1, by employing the slop-method during the time when the atmosphere was relatively homogenous. The measurements successfully demonstrate the potential

Beyond the Creative Commons Framework of Production and Dissemination of Knowledge

The thesis discusses the licensing system of the Creative Commons from the perspective of the theory of the commons mostly as formulated by Elinor Ostrom. The work starts by describing the concepts and theory of common pool resources and regime of the commons for production and distribution of these resources. The main characteristics for successful traditional commons – efficiency, equity and sus

Aktiva kolloider bygger programmerbara material

En ”kolloidal pump”, simulerad i datorn, visar hur aktivitet kan användas för att skapa nya designprinciper för kolloidala material genom att vi inte längre är bundna av termodynamikens lagar.

Congenital muscular dystrophy with laminin α2 chain-deficiency. Initiation of disease and development of treatment

Congenital muscle dystrophy type 1A (MDC1A) is a muscle disease caused bymutations in the LAMA2 gene, encoding the basement membrane protein lamininα2 chain. MDC1A patients exhibit neonatal onset of muscle weakness, progressivemuscle wasting and hypotonia, joint contractures that mostly affect elbows, hips,knees and ankles along with scoliosis and delayed motor milestones. Currently,there is no cu

Soft Constrained Subband Beamforming for Hands-Free Speech Enhancement

This paper introduces a new constrained adaptive subband beamformer algorithm for speech enhancement in acoustic telecommunication systems. The solution relies on a pre-calculated source covariance matrix and recursive estimates of background noise- and handsfree signal covariance matrices. The constraint acts as an eye-opening in a vicinity of the near-field location of the source and degradation

Speech Enhancement Employing Adaptive Beamformer with Recursively Updated Soft Constraints

A novel adaptive beamformer employing recursively updated soft constraints for acoustic speech enhancement is proposed. The beamformer operates in a subband structure to allow a time-frequency operation for each channel. Consequently, the processing performed can be viewed as a combined weighted spatial,frequency and temporal filter. The major benefit of the new recursive soft constrained beamformer

User profiling for Pre-fetching or Caching in a Catch-Up TV Network

We investigate the potential of different pre-fetchingand/or caching strategies for different user behaviour withrespect to surfing or browsing in a catch-up-TV network. To thisend we identify accounts and channels associated with strong orweak surfing or browsing respectively and study the distributionsof hold times for the different types of behaviour. Finally wepresent results from a request prWe investigate the potential of different pre-fetching and/or caching strategies for different user behaviour with respect to surfing or browsing in a catch-up-TV network. To this end we identify accounts and channels associated with strong or weak surfing or browsing respectively and study the distributions of hold times for the different types of behaviour. Finally we present results from a requ

Collective decision skill and decisive voting games

The paper discusses various representations of collective decisional skill which are useful in the evaluation of decision structures. The recursion formulas we give here and the use of the concepts of majority deficiency as well as majority and unanimity games present expedient approaches in analyzing collective competence. Using the simple majority system as benchmark, applications to certain hie

Corporate social responsibility and stock market actors : A comprehensive study

Purpose– The purpose of this study is to analyse the views stock market actors have on corporate communication of corporate social responsibility (CSR) information grounded on legitimacy and stakeholder theory. Recent findings suggest that management teams experience an increased interest and demand for CSR information from the actors on the stock market and that this underlie a focus shift. This

Application of Robust and Adaptive Pole Placement

The previous investigation showed the usefulness of a two-degree-of-freedom configuration. Such a controller can also be designed using pole placement. An adaptive controller based on this concept is developed and applied to the problem with good results. Particular features, like selection of model structure, design parameters and excitation, are also discussed.