Peritoneal metastasis is an insidious aspect of colorectal cancer. The aim of the present study was to define mechanisms regulating colon cancer cell adhesion and spread to peritoneal wounds after abdominal surgery. Mice was laparotomized and injected intraperitoneally with CT-26 colon carcinoma cells and metastatic noduli in the peritoneal cavity was quantified after treatment with a CXCR2 antago

The digital games industry is one of the fastest growing branches in the creative sector in Sweden: In the last three years the proportion of employees has increased with about 20 percent. Specific for this branch is that digital games companies compete in a highly globalized and digitalized market dominated by a few large corporations. It creates the backdrop for specific working conditions. PrevThe digital games industry is one of the fastest growing branches in the creative sector in Sweden: In the last three years the proportion of employees has increased with about 20 percent. Specific for this branch is that digital games companies compete in a highly globalized and digitalized market dominated by a few large corporations. It creates the backdrop for specific working conditions. Prev

Much contemporary critical infrastructure research has been devoted to studies of the effects of risks stemming from interdependencies between critical infrastructures, here referred to as interdependency-related risks. However, this research has placed limited emphasis on infrastructure actors’ efforts to manage such risks in practice, and it remains unclear to what extent and how critical infras

Holocene geomagnetic field models are used to study processes in Earth's core, millennial scale variations in solar activity and to relatively date geological and archaeological archives. Constructing models from magnetic field directions and intensities stored in archaeological artefacts, igneous rocks and sediment records is challenging due to the sparse data distribution and the large chronolog

Bakgrund Den 20 januari 2020 senarelades ålderspensionen i Sverige för alla yrkesgrupper. Samtidigt ökar den arbetsrelaterade sjukligheten. I ett framtidsperspektiv kommer efterfrågan på arbetskraft som kan och vill arbeta till en högre ålder att öka utifrån den globala demografiska förändringen. Att medverka till en god anställningsbarhet (employability) och hälsa är därför en central fråga och uHållbart arbetsliv för alla åldrar – swAge modellenKerstin Nilsson1, 21Högskolan Kristianstad, 2Lunds universitetBakgrundDen 20 januari 2020 senarelades ålderspensionen i Sverige för alla yrkesgrupper. Samtidigtökar den arbetsrelaterade sjukligheten. I ett framtidsperspektiv kommer efterfrågan påarbetskraft som kan och vill arbeta till en högre ålder att öka utifrån den globala demografiskaförändr

In recent years, gig work – short-term and temporary assignments mediated via digital platforms – has captured the interest of media and research and is growing as an area of academic inquiry. Previously research has mainly focused on the regulations and breadth of gig work. Gig work can be been understood as a significant break from ‘standard employment relationship’, meaning that we are now headIn recent years, gig work – short-term and temporary assignments mediated via digital platforms – has captured the interest of media and research and is growing as an area of academic inquiry. Previously research has mainly focused on the regulations and breadth of gig work. Gig work can be been understood as a significant break from ‘standard employment relationship’, meaning that we are now head

Objectives: We aimed to examine the number of teeth and masticatory function as oral health indices and clarify their roles in the pathogenesis of sarcopenia and diabetes mellitus in communitydwelling older adults. Subjects and methods: This cross-sectional study was conducted with 635 older adults in Ohnan, Shimane Prefecture, in rural Japan. The number of teeth and masticatory function (measured

PURPOSE: To analyze real-world graft survival and visual acuity outcomes of corneal transplantation in Europe. SETTING: Corneal clinics in 10 European Union member states, the United Kingdom, and Switzerland. DESIGN: Multinational registry study. METHODS: All corneal transplant procedures registered in the European Cornea and Cell Transplantation Registry (ECCTR) were identified. Graft survival of

This article examines the subjective understanding of success among members of three groups of children of immigrants from Mexico, North Africa and Turkey, in Dallas, Paris and Berlin respectively, by accounting for their educational and early labor market experiences. We utilize neo-assimilation and segmented assimilation theories and highlight their divergence with regards to downward assimilati

The chapter maintains that 20th-century decolonisation, unlike previous historical episodes wherein particular empires were resisted and declined, represented a critical juncture at which the very idea of empire was substantively challenged and radically rejected. It led to the establishment of a large number of postcolonial states and signified a decisive reshaping of the international system—bot

Tumor cells invade and spread via either a mesenchymal or an amoeboid mode of migration. Amoeboid tumor cells have a rounded morphology and pronounced RhoA activity. Here, we investigate how WNT5A signaling, a tumor promotor in melanoma, relates to Rho GTPase activity and amoeboid migration. We compared melanoma cells with low (HTB63 cells) and high (WM852 cells) WNT5A expression. HTB63 cells exhi

Background: The aim of the study was to develop and test an artificial intelligence (AI)-based method to improve the quality of [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) images. Methods: A convolutional neural network (CNN) was trained by using pairs of excellent (acquisition time of 6 min/bed position) and standard (acquisition time of 1.5 min/bed position) or sub-standard

The recent development of several tau positron emission tomography (PET) tracers represents a major milestone for the Alzheimer's disease (AD) field. These tau PET tracers bind tau neurofibrillary tangles, a key neuropathological characteristic of AD that is tightly linked to synaptic loss, brain atrophy, and cognitive decline. It is notable that these tau PET tracers show low uptake in most non-A

BACKGROUND: Recent studies have suggested that artichoke (Cynara scolymus L.) may reduce certain biochemical blood factors but the efficacy of this plant on blood pressure (BP) has not yet been investigated. In this study, we determined the clinical efficacy of C. scolymus on BP and body mass index (BMI) in hypertensive patients as an adjunctive to captopril for the first time.METHODS: The total p

Objective: To compare the real-life effectiveness of biologic therapy (a biologic disease-modifying antirheumatic drug plus methotrexate [MTX]) versus triple therapy (MTX plus sulfasalazine plus hydroxychloroquine/chloroquine) for sustained remission of rheumatoid arthritis (RA). Methods: RA patients who were registered in the nationwide Swedish Rheumatology Quality Register between 2000 and 2012

Apolipoprotein E (ApoE), an important mediator of lipid transportation in plasma and the nervous system, plays a large role in diseases such as atherosclerosis and Alzheimer's. The major allele variants ApoE3 and ApoE4 differ only by one amino acid. However, this difference has major consequences for the physiological behaviour of each variant. In this paper, we follow (i) the initial interaction