Children and adolescents with atopic disease who have allergic asthma and/or rhinitis with and without atopic dermatitis may have hidden, clinically relevant contact allergies.

Non-motor symptoms (NMS) of Parkinson's disease remain the most under-appreciated and under-researched when taken as a whole. Data is emerging that it is the "totaL" burden of NMS that is the major determinant of quality of life not a single NMS such as depression for instance. Only recently validated tools such as the NMSQuest which empowers patients to declare NMS and the NMS scale, the SCOPA sc

This paper examines the recent growth in projects designed to enable individuals to 'do their bit' in the struggle to limit climate change. It discusses them in relation to a long-standing critique of trends towards individualisation amongst environmentalists. It suggests that this critique misses the complex way that subjects are produced by these practices and proposes to analyse subjectificatio

The aim of this study was to establish the main drivers of the spatial variability in growing season CH4 flux within an arctic wetland ecosystem. During 3 years (2011-2013) we measured CH4 flux and potential drivers, e.g., CO2 fluxes (net ecosystem exchange (NEE), gross primary productivity (GPP) and ecosystem respiration), temperature, water table depth, pore-water concentration of organic acids

A framework for an empirical parameterization (EP) of heterogeneous nucleation of ice crystals by multiple species of aerosol material in clouds was proposed in a 2008 paper by the authors. The present paper reports improvements to specification of a few of its empirical parameters. These include temperatures for onset of freezing, baseline surface areas of aerosol observed in field campaigns over

Dementia has been associated with an increased risk of fractures. These associations may be explained by an impaired cognitive function, as well as comorbid illness and toxic reaction from drugs. To investigate whether cognitive function in young, healthy individuals already affects the risk of fractures, overall cognitive function scores were calculated from four cognitive tests accomplished duri

Reduced forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) have been associated with increased incidence of cardiovascular diseases. However, whether reduced lung function is also a risk factor for incidence of atrial fibrillation (AF) is still unclear. We aimed to determine whether lung function predicted AF in the Malmö Preventive Project, a large population-based coho

In this study we report on the production of metal-hydroxide-coated macroporous polymers (MHCMPs), which mainly involves a polyacrylamide backbone coated with iron-aluminium double hydroxides. The coating process is fast, occurs using relatively mild reagents at room temperature, and can be repeated multiple times, thus making it a very simple and flexible process. Electron microscopy and energy d

Specificity and versatility in cyclic AMP (cAMP) signalling are governed by the spatial localisation and temporal dynamics of the signal. Phosphodiesterases (PDEs) are important for shaping cAMP signals by hydrolyzing the nucleotide. In pancreatic beta-cells, glucose triggers sub-plasma-membrane cAMP oscillations, which are important for insulin secretion, but the mechanisms underlying the oscilla

OBJECTIVES: To investigate the validity over time of the fingertip-to-floor test (FTF) and the straight leg raising test (SLR) using the Roland Morris Disability Questionnaire (RMDQ) and correlation coefficient (r), and to assess the predictive value of factors related to the change in RMDQ over 12 months using multivariate regression analysis. DESIGN: Longitudinal study. SETTING: Outpatient

This study investigates strategic voting for small parties in proportional representation systems, in previous work sometimes referred to as threshold insurance voting (Cox, 1997). Starting from theories of rational voting (Downs, 1957), three conditions for threshold insurance voting are developed: the voter considers potential government outcomes, votes for a party at risk of falling below an el

Three new species of Achrysocharoides are described, one from northern Europe, A. platanoidae sp. nov., one from central Europe and the U. S. A., A. robiniae sp. nov., and one from the U. S. A., A. robinicolus sp. nov. The descriptions are based on material reared from microlepidopterans of the genus Phyllonorycter Hubner (Gracillariidae): A. platanoidae from P. platanoidella (Joannis) on Acer pla

Structural chromosome rearrangements may result in the exchange of coding or regulatory DNA sequences between genes. Many such gene fusions are strong driver mutations in neoplasia and have provided fundamental insights into the disease mechanisms that are involved in tumorigenesis. The close association between the type of gene fusion and the tumour phenotype makes gene fusions ideal for diagnost

3C protease of Coxsackievirus B3 (CVB3) plays an essential role in the viral replication cycle, and therefore, emerged as an attractive therapeutic target for the treatment of human diseases caused by CVB3 infection. In this study, we report the first account of the molecular impact of the T68A/N126Y double mutant (MutantBound) using an integrated computational approach. Molecular dynamics simulat

Biorefining of crops for production of power, transport fuels, and a diverse array of chemicals has potential for providing significant added economic value to biomass. A shift in the industrial resource base from fossil resources to biomass also requires a shift in the technology base for producing, handling, and processing of raw materials. Biotechnology will play an important role in providing

The morphogenesis of organs necessarily involves mechanical interactions and changes in mechanical properties of a tissue. A long standing question is how such changes are directed on a cellular scale while being coordinated at a tissular scale. Growing evidence suggests that mechanical cues are participating in the control of growth and morphogenesis during development. We introduce a mechanical

Context. Development of safety-critical systems is mostly governed by process-heavy paradigms, while increasing demands on flexibility and agility also reach this domain. Objectives. We wanted to explore in more detail the industrial needs and challenges when facing this trend. Method. We launched a qualitative survey, interviewing engineers from four companies in four different industry domains.

Topological insulators are a class of quantum materials in which time-reversal symmetry, relativistic effects and an inverted band structure result in the occurrence of electronic metallic states on the surfaces of insulating bulk crystals. These helical states exhibit a Dirac-like energy dispersion across the bulk bandgap, and they are topologically protected. Recent theoretical results have sugg

We show how one can back out implied forward volatility term structures from credit default swap spreads. Such forward stock volatility term structures are useful for instance in forward start option pricing. We find the term structure to be downward-sloping, and the credit market's volatility forecasts tend to vary more across time than across maturities. Long-term volatility expectations, in tur