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One man, 73 years, and 25 species. Evaluating phenological responses using a lifelong study of first flowering dates.

Phenological shifts linked to global warming reflect the ability of organisms to track changing climatic conditions. However, different organisms track global warming differently and there is an increasing interest in the link between phenological traits and plant abundance and distribution. Long-term data sets are often used to estimate phenological traits to climate change, but so far little has

Low variability and absence of phenotypic correlates of Clock gene variation in a great tit Parus major population

Studies of a range of taxa, including birds, have revealed latitudinal clines in allele length at the conserved Clock locus, a gene with known influences on behaviour and physiology. Such clines might reflect adaptation to seasonal variation, a suggestion supported by a recent within-population analysis of blue tits Cyanistes caeruleus, which found associations between Clock genotype and timing of

Scaling up requirements engineering - exploring the challenges of increasing size and complexity in market-driven software development

[Context & motivation] Growing software companies with increasing product complexity face the issue of how to scale up their Requirements Engineering (RE) practices. In market-driven requirements engineering, release planning and scoping decisions are increasingly challenging as the size and complexity increases. [Problem] This paper presents initial results of an on-going exploratory, qualita

Are children with stronger cognitive capacity more or less disturbed by classroom noise and dysphonic teachers?

Purpose: This study aimed to explore if dysphonic voice quality affects children's performance on a language comprehension test, the Test for Reception of Grammar-2 (TROG-2), performed in simultaneous background noise (non-semantic babble). A further aim was to investigate the role of Working Memory Capacity (WMC) and Executive Functioning (EF) in coping with the voice against a background of babb

Low rate of fistula formation after Sommerlad palatoplasty with or without lateral incisions: An analysis of risk factors for formation of fistulas after palatoplasty.

The aim of palate repair is to restore normal eating and drinking function and normal speech development and still maintain undisturbed facial growth. The repair should be performed with a low frequency of complications. A number of factors are thought to contribute to the formation of fistulas after palatoplasty; they include patient factors and treatment issues. The aim of this study was to revi

Experimental investigation of condensation in micro-fin tubes of different geometries

An experimental investigation was performed for single-phase flow and condensation characteristics inside five micro-fin tubes with the same outer diameter 5 mm and helix angle 18°. Data are for mass fluxes ranging from about 200 to 650 kg/m2 s. The nominal saturation temperature is 320 K, with inlet and outlet qualities of 0.8 and 0.1, respectively. The results suggest that Tube 4 has the highest

Remote Excitation Polarization-Dependent Surface Photochemical Reaction by Plasmonic Waveguide

For the first time, we report remote excitation polarization-dependent surface photochemical reaction by plasmonic waveguide. Remote excitation polarization-dependent surface-enhanced Raman scattering (SERS) spectra indicate a surface photochemical reaction that p-aminothiophenol is converted to p,p'-dimercaptoazobenzene (DMAB) induced by the plasmonic waveguide. Surface plasmon polaritons generat

Prognostic value of electroencephalography (EEG) after out-of-hospital cardiac arrest in successfully resuscitated patients used in daily clinical practice.

Out-of-hospital cardiac arrest (OHCA) is associated with a poor prognosis and predicting outcome is complex with neurophysiological testing and repeated clinical neurological examinations as key components of the assessment. In this study we examine the association between different electroencephalography (EEG) patterns and mortality in a clinical cohort of OHCA-patients.

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

Background High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomar

Invasive Mycobacterium marinum infection of the hand.

Abstract Mycobacterium marinum infection of the hand is rare. We report the case of a 39-year-old man with M marinum infection that resulted in a chronic soft tissue infection, extensor tendon synovitis, and arthritis of the metacarpophalangeal (MCP) joints. The cause was probably tropical freshwater fishes.

Clotting factor level is not a good predictor of bleeding in carriers of haemophilia A and B.

Carriers of haemophilia are known to have a wide range of clotting factor levels and bleeding symptoms. This study aimed at investigating whether carriers of severe and moderate haemophilia had an increased bleeding tendency, compared with a control group, using a condensed version of a bleeding assessment tool developed by the Molecular and Clinical Markers for the Diagnosis and Management of Typ

Modeling Nanosized Single Molecule Objects: Dendronized Polymers Adsorbed onto Mica

We attempt to provide direct evidence for the suggested behavior of dendronized polymers as molecular objects (i.e., single shape persistent macromolecules). For this purpose, the microscopic structure of dendronized polymers adsorbed onto mica has been investigated using atomistic molecular dynamics simulations. We find that the shape of the second to fourth generation dendronized polymers is bas

A life-course study of cognitive reserve in dementia: Dementia incidence in inpatient registers and mmse test scores in a clinical study in sweden

Cognitive reserve helps mitigate the impact of pathology on the clinical expression of dementia. Education and occupational complexity are considered as contributors to reserve, although it has been argued that cognitive reserve is likely formed over the life-course. A life-course model of cognitive reserve in dementia risk has not yet been tested. We apply a life-course model and examine if schoo

Abandoned and illegitimate, a double mortality penalty? Mortality of illegitimate infants in the foundling hospital of Madrid, La Inclusa (1890-1935)

This paper examines the existence of a mortality penalty for illegitimate abandoned infants in the Foundling Hospital of Madrid, La Inclusa, during the period 1890-1935, in the context of the mortality experience of the city. A rich dataset on the life histories of all infants abandoned in the city of Madrid (almost 60,000 children), nominally linked to births, has allowed the study of the determi

Transverse Momentum Distribution and Nuclear Modification Factor of Charged Particles in p plus Pb Collisions at root(NN)-N-s=5.02 TeV

The transverse momentum (pT) distribution of primary charged particles is measured in minimum bias (non-single-diffractive) p + Pb collisions at root(NN)-N-s = 5.02 TeV with the ALICE detector at the LHC. The pT spectra measured near central rapidity in the range 0.5< p(T) < 20 GeV/c exhibit a weak pseudorapidity dependence. The nuclear modification factor R-pPb is consistent with unity for p(T) a

Gene-Lifestyle and Gene-Pharmacotherpy Interactions in Obesity and Its Cardiovascular Consequences.

Obesity is a highly prevalent complex trait that raises the risk of other chronic diseases such as type 2 diabetes, certain cancers, sleep apnea, and cardiovascular disease, and shortens lifespan. Clinical intervention studies focused on weight loss and epidemiological studies of obesity indicate that genetic variation may modify the relationship between lifestyle behaviors and weight loss or weig

Simulating the Mammalian blastocyst - molecular and mechanical interactions pattern the embryo.

Mammalian embryogenesis is a dynamic process involving gene expression and mechanical forces between proliferating cells. The exact nature of these interactions, which determine the lineage patterning of the trophectoderm and endoderm tissues occurring in a highly regulated manner at precise periods during the embryonic development, is an area of debate. We have developed a computational modeling