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Context: Preterm birth is followed by a decrease in circulatory levels of IGF-I and IGF binding protein-3 (IGFBP-3), proteins with important neurogenic and angiogenic properties. Objective: To evaluate effects of intravenous administration of fresh frozen plasma (FFP) from adult donors on circulatory levels of IGF-I and IGFBP-3 in extremely preterm infants. Design, setting and patients: A prospect
