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Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

Recently, common noncoding variants in the TCF7L2 gene were strongly associated with increased risk of type 2 diabetes in samples from Iceland, Denmark, and the U.S. We genotyped 13 single nucleotide polymorphisms (SNPs) across TCF7L2 in 8,310 individuals in family-based and case-control designs from Scandinavia, Poland, and the U.S. We convincingly confirmed the previous association of TCF7L2 SNP

Hypertension in primary hyperparathyroidism in relation to histopathology

Hypertension in primary hyperparathyroidism (HPT) was previously attributed to hypercalcemia per se or to impaired kidney function. Of 441 consecutive patients operated on for HPT over 24 years, 57% were hypertensive. Preoperative blood pressure remained fairly constant during the study period, despite otherwise markedly changing clinical picture with, latterly, more asymptomatic patients. The pre

Experiments in a pilot-scale impulse unit - heat transfer and water removal rates

This is the first paper out of two dealing with heat transfer, water removal and energy efficiencies in an impulse unit in the pilot-scale research paper machine EuroFEX, located at the Swedish Pulp and Paper Research Institute (STFI) in Stockholm, Sweden. The paper produced was made of kraft pulp and with basis weights of 60-120 g/m(2). The roll surface temperature ranged from ambient temperature

Characterisation of acyl-ACP desaturases from Macadamia integrifolia Maiden & Betche and Nerium oleander L.

The seed oil in Macadamia integrifolia contains about 30% palmitoleic acid (16:1(Delta9)) and Nerium oleander about 12% isoricinoleic acid (Delta9-hydroxy-18:1(Delta12)). It has been shown that palmitoleic acid can be produced by acyl-acyl carrier protein (ACP) desaturases and it has also been shown that fatty acid hydroxylation can occur via direct substitution of a hydrogen atom. Therefore it se

Effect of random walk phase noise on MIMO measurements

In this paper we study the influence of phase noise from free-running local oscillators on SAGE signal parameter estimation. Phase noise is here modeled as a random-walk process. We present phase noise estimates from our LUND RUSK MIMO channel sounder, and draw conclusions on requirements on local oscillators' phase noise in terms of the Allan variance. We investigate an error propagation effect i

The Housing Enabler: An objective tool for assessing accessibility.

This paper describes an instrument - the Housing Enabler - used in the assessment of housing accessibility. The tool was developed from the original Enabler idea by Steinfeld et al (1979), resulting in an instrument for reliable assessment of the accessibility of the housing environment and the immediate outdoor environment in terms of occupational therapy. Apart from a description of the instrume

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Abstract in Spanish Inger Enkvist, catedrática de español de la Universidad de Lund, Suecia, trabajó durante tres años en un proyecto de investigación junto con Ángel Sahuquillo, de la Universidad de Sodertorn, también en Suecia, en un proyecto titulado ”Identidad e ideología en la literatura hispánica: un estudio basado en la obra de Juan Goytisolo”. El resultado más interesante no fue los aspect

The impact of forest residue removal and wood ash amendment on the growth of the ectomycorrhizal external mycelium

Intensive harvesting of forest residues for energy production may lead to the depletion of organic matter and mineral nutrients in the forest floor. In order to restore nutrient content wood ash has been suggested as a fertiliser. Ectomycorrhizal (EM) fungi arc involved in the nutrient uptake of forest trees and this study investigates the influence of intensive harvesting and wood ash fertilisati

Indication of quark deconfinement and evidence for a Hubble flow in 130 and 200 GeV Au+Au collisions

Buda-Lund hydro-model fits are compared to BRAHMS, PHENIX, PHOBOS and STAR data on identified particle spectra, two-particle Bose-Einstein or HBT correlations, charged particle pseudorapidity distributions and pseudorapidity as well as PT dependent elliptic flow in rootS(NN) = 130 and 200 GeV Au+Au collisions at RHIC. Preliminary results indicate that 7/8 of the particle emitting volume is rather

Combined computational and crystallographic study of the oxidised states of [NiFe] hydrogenase

[NiFe] hydrogenases catalyse the reaction H2 <-> 2H(+) + 2e(-). Several states of the enzyme have been observed by spectroscopic methods. Among these, the two most oxidized states, called the unready Ni-A and Ni-SU states, have been especially intriguing, because they take a much longer time to activate than the corresponding ready Ni-B and Ni-SI states. It has recently been suggested that the unr

A high-resolution FT-IR study of the fundamental bands v(7), v(8), and v(18) of ethene secondary ozonide

Ozonization reaction of ethene in neat film at 77 K was performed. Separation of ethene secondary ozonide from the other products of the reaction was performed by continuous pumping of the reactor. Only the products, which evaporated from the walls of the reactor at 185 K, were transferred to the gas cell. The high-resolution infrared absorption spectrum of gaseous ethene secondary ozonide (C2H4O3