In contrast to mature cardiomyocytes which have limited regenerative capacity, pluripotent stem cells represent a promising source for the generation of new cardiomyocytes. The tendency of pluripotent stem cells to form teratomas and the heterogeneity fromvarious differentiation stages and cardiomyocyte cell sub-types, however, are major obstacles to overcome before this type of therapy could be a

Background: Tracking small migrant organisms worldwide has been hampered by technological and recovery limitations and sampling bias inherent in exogenous markers. Naturally occurring stable isotopes of H (delta H-2) in feathers provide an alternative intrinsic marker of animal origin due to the predictable spatial linkage to underlying hydrologically driven flow of H isotopes into foodwebs. This

Composition is a practice of key importance in software engineering. When real-time applications are composed, it is necessary that their timing properties (such as meeting the deadlines) are guaranteed. The composition is performed by establishing an interface between the application and the physical platform. Such an interface typically contains information about the amount of computing capacity

Two new ternary Cu-In-Sb compounds Cu7In2.5Sb0.5 and Cu2In0.75Sb0.25 are presented. Both compounds are Ni2In type superstructures with vacancies in the pseudohexagonal network. Additionally, the pseudocubic nature of the compounds and Ni2In type (super)structures, in general, is discussed. Remarkably, a large number of pseudo-five-fold and pseudo-three-fold axes contribute to generate a pseudocubi

In this work, we report on an unconventional experimental procedure useful for thermometric measurements on the basis of high-resolution vibrational coherent anti-Stokes Raman scattering (CARS) generated using conventional lasers. The high spectral dispersion of 0.02 cm(-1)/pixel is achieved by means of some specific spectral arrangements (single-mode pump laser and diffraction grating providing s

Aim. To develop a patient questionnaire specific to intrapartal care, based on the theoretical foundation of the general instrument Quality from the Patient's Perspective (QPP). Background. Existing general patient questionnaires do not take intrapartal care aspects fully into account, and available intrapartal-specific patient questionnaires tend to have a weak theoretical foundation. Design. A c

Results from interviews with representatives from 13 Swedish municipalities and studies of fire protection documentation are presented in this report. The results provide an overview of the typical fire protection systems used to prevent deliberately lit fires in schools and kindergartens. There is great variety of which fire protection systems that is used in the municipalities. The measures ment

Abstract in UndeterminedDue to his background as a Platonist, Justin Martyr’s relation to Stoic philosophy has not gained as much attention from scholars as his relation to Platonism, and his relationship to contemporary Stoicism has been largely overlooked. The present essay provides an overview and analysis of Justin’s references and allusions to Stoics and Stoic philosophy, with particular focu

Here the feasibility of layers based on the conducting polymer polyaniline (PANI) as component of glucose biosensors using glucose oxidase (GOx) as enzyme and [Os(bpy)(2)(4-aminomethylpyridine)Cl]PF6 (OsCmplx) as electrochemical mediator, is evaluated. Particularly, PANI was employed to obtain a nanostructured macroporous material (m-PANI) around polystyrene nanoparticles taken as template and the

Post-sternotomy mediastinitis is a serious complication after cardiothoracic surgery and contribute significantly to post-operative morbidity, mortality, and healthcare costs. Negative pressure wound therapy is today's golden standard for post-sternotomy mediastinitis treatment. A systematic literature search was conducted at PubMed until October 2012 to analyse whether vacuum-assisted closure tec

In a recent study,Westerlund (Empir Econ 37:517–531, 2009) shows that the performance of the popular LLC (Levin et al., J Econ 108:1–24, 2002) panel unit root test depends critically on the choice of lag truncation used when correcting for serial correlation, and that it is only when this parameter is set as a function of time that the power raises above size. The purpose of the current paper is t

To probe internal motions in proteins on the 10−8−10−5 s time scale by NMR relaxation, it is necessary to eliminate protein tumbling. Here, we examine to what extent magnetic relaxation dispersion (MRD) experiments on the water 1H resonance report on protein motions in this time window. We also perform a critical test of two physically distinct mechanisms that have been proposed to explain and int

Hematopoietic stem cells (HSC) are multipotent and possess self-renewal capacity. Thus, they can sustain a life-long hematopoiesis and are also capable of restoring the hematopoietic system when transplanted to a patient. In allogeneic hematopoietic stem cell transplantation (HSCT), a potent graft-versus-leukemia (GvL) effect must be balanced against the concomitant risk of severe immunological re

Popular Abstract in Swedish Drygt en tiondel av Sveriges befolkning lider av hjärt-kärlsjukdom som också är den vanligaste dödsorsaken. Många av de akuta sjukdomstillstånden orsakas av att en bit inflammerad blodkärlsvävnad bryts loss från sitt fäste i något av de stora blodkärlen, färdas med blodet och täpper till blodflödet i mindre blodkärl. Detta leder till syrebrist och celldöd nedströms om dAbstract Atherosclerosis is a multifactorial disease, but an unbalanced immune system plays a critical role in the disease development. A common theory states that a continuous stress to the vascular vessel wall initiates a repair process that however is insufficient to completely heal the tissue. This imbalance is associated with accumulation of cholesterol, which is an essential component of ce

Background and purpose Adequate depth of cement penetration and cement mantle thickness is important for the durability of cemented cups. A flanged cup, as opposed to unflanged, has been suggested to give a more uniform cement mantle and superior cement pressurization, thus improving the depth of cement penetration. This hypothesis was tested experimentally. Materials and methods The same cup desi

Circulating metabolites associated with insulin sensitivity may represent useful biomarkers, but their causal role in insulin sensitivity and diabetes is less certain. We previously identified novel metabolites correlated with insulin sensitivity measured by the hyperinsulinemic-euglycemic clamp. The top-ranking metabolites were in the glutathione and glycine biosynthesis pathways. We aimed to ide