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Quantification Methods for Clinical Studies in Nuclear Medicine - Applications in AMS, PET/CT and SPECT/CT

Popular Abstract in Swedish Inom området diagnostisk nuklearmedicin används radioaktiva läkemedel som ges (administreras) till patienterna i syfte att diagnostisera ett antal olika sjukdomstillstånd. Då man tar fram nya radioaktiva läkemedel för användning inom diagnostisk nuklearmedicin handlar det många gånger om att uppskatta mängden av ett visst upptag av radiofarmakat i olika organ och vävnadAn essential part of the development of new radiopharmaceuticals for use in diagnostic nuclear medicine is the determination of its biokinetic properties. The uptake and turn-over of the radiopharmaceutical in the source organs is of great interest since this could determine whether the radiopharmaceutical would be suitable for clinical use or not. It is also important that the biokinetics and dos

Selective Sorbents - Silica-immobilized affinity ligands and molecularly imprinted polymers

The development of selective sorbents for the separation of various molecules, preferentially biomolecules, is described in this work. Affinity ligands were immobilized on small silica particles and used in high-performance liquid affinity chromatography (HPLAC). With this technique, it is possible to perform fast, selective and efficient bioseparations. Methods were developed for the preparation

Product development problematics

The study of life in confined extreme environments to give guidance for issues and conditions for the design, development and production of objects on Earth. We use long term living in confined extreme environments as starting point for studies of product development concerning objects and living environments. By using the extreme environment as a backdrop for our studies we aim to achieve a labor

MHC and Transgenic Mice. A study into polymorphism and function of class I and class II molecules

Popular Abstract in Swedish Vi är under ständig attack från mikroorganismer som vill leva på oss och i oss. Vissa av dessa är vanligtvis nyttiga medan andra är sjukdomsframkallande. Kroppens försvar mot invaderande organismer består av många delar. Ytterst sitter huden som en mekanisk barriär, vi har slem och epitelceller i luftvägar och magtarmkanal samt skyddande ämnen i exempelvis tårvätska. I Transplantation antigens encoded in the major histocompatibility complex (MHC) bind peptides and present them to T cells. We showed that mouse T cells expressing transgenic human CD8 can recognise human MHC class I. Expression on mature T cells is sufficient for activation in a mixed lymphocyte culture but expression both on thymocytes and mature T cells is necessary for peptide specific MHC restr