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A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort

Objectives The aim of this study was to confirm the influence of TNFSF4 polymorphisms on systemic sclerosis (SSc) susceptibility and phenotypic features. Methods A total of 8 European populations of Caucasian ancestry were included, comprising 3014 patients with SSc and 3125 healthy controls. Four genetic variants of TNFSF4 gene promoter (rs1234314, rs844644, rs844648 and rs12039904) were selected

Phenotypic protein profiling of different B cell sub-populations using antibody CD-microarrays

Antibody microarrays enable extensive protein expression profiling, and provide a valuable complement to DNA microarray-based gene expression profiling. In this study, we used DotScan™ antibody microarrays that contain antibodies against 82 different cell surface antigens, to determine phenotypic protein expression profiles for human B cell sub-populations. We then demonstrated that the B cell pro

The affective profiles, psychological well-being, and harmony: environmental mastery and self-acceptance predict the sense of a harmonious life

Background. An important outcome from the debate on whether wellness equals happiness, is the need of research focusing on how psychological well-being might influence humans' ability to adapt to the changing environment and live in harmony. To get a detailed picture of the influence of positive and negative affect, the current study employed the affective profiles model in which individuals are c

Effects of lifestyle factors on concentrations of salivary cortisol in healthy individuals

Objective . Salivary cortisol is widely used in occupational health research. However, many ordinary daily activities can influence the concentrations of cortisol and the interpretation of field studies. The aim of the present study was to evaluate the effect of lifestyle factors on salivary cortisol in everyday settings. Material and methods . Healthy employees participated in one or more sub-stu

A Coherent Signature of Anthropogenic Nitrogen Deposition to Remote Watersheds of the Northern Hemisphere

Humans have more than doubled the amount of reactive nitrogen (Nr) added to the biosphere, yet most of what is known about its accumulation and ecological effects is derived from studies of heavily populated regions. Nitrogen (N) stable isotope ratios (N-15:N-14) in dated sediments from 25 remote Northern Hemisphere lakes show a coherent signal of an isotopically distinct source of N to ecosystems

Uncovering the corporate brand's core values

Purpose - This paper aims to describe the uncovering of a corporate brand's core values and implications for strategic management of its track record. Design/methodology/approach - The paper examines the specific track records of Volvo, IKEA, IBM, and Scanpump, focusing on core values and how they evolve. Based on multiple sources of evidence, the track records of the case companies emerge as patt

The case of PRO

Icelandic case agreement suggests that nominative case is active in PRO infinitives in much the same way as in finite clauses, thus posing a difficult and a long-standing problem for generative (GB and minimalist) case theory and the PRO Theorem. In this article, I examine the Icelandic facts in detail, illustrating that the unmarked and common nominative morphology in Icelandic PRO infinitives is

Variants in MTNR1B influence fasting glucose levels

To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observ

Measurement of the cross-section for b-jets produced in association with a Z boson at root s=7 TeV with the ATLAS detector ATLAS Collaboration

A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons,

Single and multi-user cooperative MIMO in a measured urban macrocellular environment

We study the potential benefits of cooperative multiple-input multiple-output signaling from multiple coherent base stations with one or more mobile stations in an urban macrocellular environment at 2.66 GHz. The analysis uses fully-coherent measurements of the channel from three base stations to a single mobile station equipped with four antennas. The observed channels are used to explore the gai

Muscle function and physical activity in pre-pubertal school children

Popular Abstract in Swedish Bakgrund: Regelbunden fysisk aktivitet och träning anses som en livsstilsfaktor som kan förbättra muskelstyrkan, skelettet, konditionen och kroppssammansättningen. För barn och ungdomar är fysisk aktivitet inte bara viktigt för att träna de muskulära funktionerna, koordinationen och balansen. I ett större perspektiv kan en fysiskt aktiv livsstil också minska risken för Background: Regular participation in physical activity or organized exercise is regarded as one important lifestyle factor that could improve musculoskeletal health, fitness and body composition. For children and adolescents physical activity is important not only in training of the neuromuscular system, coordination and balance, but in a wider perspective, for adopting a lifestyle that possibly r

Investigation of local flame structures and statistics in partially premixed turbulent jet flames using simultaneous single-shot CH and OH planar laser-induced fluorescence imaging

We report on the application of simultaneous single-shot imaging of CH and OH radicals using planar laser-induced fluorescence (PLIF) to investigate partially permixed turbulent jet flames. Various flames have been stabilized on a coaxial jet flame burner consisting of an outer and an inner tube of diameter 22 and 2.2 mm, respectively. From the outer tube a rich methane/air mixture was supplied at

Screening for alpha1-antitrypsin deficiency in Lithuanian patients with COPD

Background: Alphal-antitrypsin (AAT) deficiency is an under-diagnosed condition in patients with chronic obstructive pulmonary disease (COPD). The objective of the present screening was to estimate the AAT gene frequency and prevalence and to identify AAT deficiency cases in a large cohort of Lithuanian patients with COPD. Methods: A nationwide program of AAT deficiency was conducted in 1167 COPD

Make-or-Buy Decisions and the Manipulability of Performance Measures

The make-or-buy decision is analyzed in a simple framework combining contractual incompleteness with the existence of an imperfect but contractible performance measure. Contractual incompleteness gives rise to two regimes, identified with make and buy. The performance measure on which comprehensive contracts can be written is imperfect in the sense of being subject to manipulation. The performance

The association between the IGF-I axis, thyroid hormones and cortical bone in patients with mild primary hyperparathyroidism

Objectives. Primary hyperparathyroidism (PHPT) is associated with low bone mineral density (BMD) and increased risk of osteoporotic fractures. This study investigated whether the IGF-I axis and thyroid hormones are associated with BMD and osteoporotic fractures before and after parathyroidectomy (PTX). Materials and methods. Forty-five patients with mild PHPT were examined before and 1 year after