The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression

The Fra a I allergen in strawberry (Fragaria ananassa) is homologous to the major birch pollen allergen Bet v 1, which has numerous isoforms differing in terms of amino acid sequence and immunological impact. To map the extent of sequence differences in the Fra a I allergen, PCR cloning and sequencing was applied. Several genomic sequences of Fra a 1, with a length of either 584, 591 or 594 nucleo

Condensation of 1-cyanomethyl-2,3,3-trimethyl-3H-indolium perchlorate with ortho-hydroxy-substituted aromatic aldehydes afforded 1-cyanomethylindoline spiropyrans. The latter underwent rearrangement to bridged 1,3-benzoxazepino[3,2-a]indoles on treatment with a base. The mechanism of the rearrangement includes generation of a carbanion stabilized by a cyano Group.

Low-dimensional semiconductors offer interesting physical phenomena but also the possibility to realize novel types of devices based on, for instance, ID structures. By using traditional top-down fabrication methods the performance of devices is often limited by the quality of the processed device structures. In many cases damage makes ultra-small devices unusable. In this work we present a recent

We study dissipative properties of the motion of a slow nuclear collective variable weakly coupled to a complex quantum environment formed by the fast nucleonic degrees of freedom. The fast quantum mechanical subsystem is treated within the random matrix approach, where the complexity of the nucleonic degrees of freedom's motion can be changed by a parameter from regular to fully chaotic. Classica

Abstract is not available.

Kinetic properties of the monomeric enzyme dUTPase from herpes simplex virus type 1 (HSV) were investigated and compared to those previously determined for homotrimeric dUTPases of bacterial and retroviral origins. The HSV and Escherichia coli dUTPases are equally potent as catalysts towards the native substrate dUTP with a kcat/KM of about 107 M-1 s-1 and a KM of 0.3 μM. However, the viral enzyme

Since it is difficult to predict the future using the concept of strategy as options on the future introduced by Peter J. Williamson is a way of circumventing this insecurity. This study further develops this theory by introducing a process or framework for choosing the options based on scenario analysis. By using scenario analysis small glimpses of possible futures can be seen and by selecting op

BRCA1 mutations, although implicated in disease predisposition in a major part of the hereditary breast cancer population, do not seem to be crucially involved in tumorigenesis of sporadic breast and ovarian cancers. This suggests that tumours arising in BRCA1 mutation carriers may differ from BRCA1 negative hereditary and sporadic cancer in genetic and biological features, as well as in clinical

We construct hadronic potentials that describe the spectrum and decays of electromagnetic bound states of hadrons, and are consistent with Chiral Perturbation Theory. This procedure enables one to clarify the status of the calculations-based on potential models-of the electromagnetic corrections to the observables of hadronic atoms and to the strong scattering amplitudes at low energy.

The work with the Nordic consensus report on asthma management started some years ago. The Nordic countries have common socioeconomic conditions. We acknowledge the international as well as other European guidelines providing valuable recommendations. Nevertheless, we felt the need to combine the common Nordic experiences in order to have a local statement of asthma and asthma care, based upon Nor

Popular Abstract in Swedish Det ljus som vi vanligen ser, har spritts av objekten i vår omgivning. Ett annat ljusfenomen är fluorescens, som kan användas inom olika områden för analys av prover. Olika substanser ger skilda fluorescensprofiler. Om dessa inte helt överlappar varandra kan substanserna särskiljas. Områden, där ljusdiagnostik har använts inom ramen för detta arbete, är kemisk analys, mIn this thesis spectroscopic techniques have been used in the fields of analytical chemistry, environmental and medical applications. In analytical chemistry, laser induced fluorescence was used to image the separation of substances during capillary electrophoresis. Here, an optical fibre imaging technique facilitated a higher sensitivity compared with a lens imaging technique. The motion of the s

Hypoglycemic sulfonylureas represent a group of clinically useful antidiabetic compounds that stimulate insulin secretion from pancreatic beta cells. The molecular mechanisms involved are not fully understood but are believed to involve inhibition of potassium channels sensitive to adenosine triphosphate (KATP channels) in the beta cell membrane, causing membrane depolarization, calcium influx, an

We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 pin in the follicle, obviously introduced mechanically rather than by a di

Different strategies for reducing emissions of nitrogen oxides and carbon dioxide from the Swedish transportation sector are evaluated by making scenarios for the year 2015, using a bottom-up approach. Methods for reducing emissions of carbon monoxide, hydrocarbons, and sulphur dioxide are discussed more briefly. The scenarios are based on official forecasts of future passenger and goods transport

Popular Abstract in Swedish Välfärd, säkerhet och fertilitetsnivån: En global analys, 1985 och 1995.Aims: This study aims to find an explanation for differentials in the level of fertility through the analysis of the recent data of seventy-eight developed and developing countries. The main approach adopted is the specification of a macroeconomic interdependent model testing hypotheses within an institutional point of view. Methods: This is a cross-sectional data analysis in a system of four equ

The object of this paper is to develop a discussion of territoriality in the built environment as a way of dealing with issues of accessibility and the public nature of urban space. A discussion of territoriality makes it possible to deal with issues of spatial control and access in detail, as well as to maintain some of the complexity in the discussion by refraining from solely analysing these is