AIMS: The very long-term outcome of patients who survive the first few years after receiving cardiac resynchronization therapy (CRT) has not been well described thus far. We aimed to provide long-term outcomes, especially with regard to the occurrence of sudden cardiac death (SCD), in CRT patients without (CRT-P) and with defibrillator (CRT-D).METHODS AND RESULTS: A total of 1775 patients, with is

Purpose: The purposes of this study were to retrospectively study whether comprehensive geriatric assessment (CGA) given to community-dwelling old patients with high health care usage has effects regarding: (1) the cause of death and (2) the quality of the provided palliative care when compared to patients without CGA-based care. Method: This study includes secondary data from a randomised control

This study analyses the influence of green roofs in different heights of the urban canopy layer: from the pedestrian level, up to 1m above the rooftop, in a social housing project in the South of Brazil. In order to quantify the cooling contribution of green roofs to the local microclimate, the housing project was simulated with ENVI-met 4.0 in the summer season. The variables used to assess the g

BACKGROUND: Defensive coping (DefS) was associated with a vulnerable cardiovascular profile in Blacks. The copeptin/vasopressin system is a manifestation of hypothalamic-pituitary-adrenal-axis activity and may act as an acute compensatory mechanism when there is a disruption in volume-loading homeostasis, i.e. when cardiac stress is evident. Whether DefS will influence associations between copepti

The publication (originally an M.A. thesis at the Catholic University of Lublin) analyzes and interprets the imagery of the mosaics covering the floor of the northern aula of the paleochristian basilica. The latter was uncovered at the beginning of the 20th century under the Patriarchal Basilica of Aquileia. The iconography of animals depicted on the mosaics is unparalleled and has been a subject

IntroductionWithin the concept of waste water treatment the opportunity of integrating pervaporation has been widely recognised. Applying pervaporation, generally two different process designs can be applied – vacuum and sweep gas pervaporation. Previous research focused primarily exclusive on one of this process designs. In this study the benchmarks of vacuum and sweep gas pervaporation are defin

Over the years several models have been developed to describe hydrophobic pervaporation. The different approaches can be generally classified as process-orientated or membrane-orientated. Among these models the resistance-in-series model (RSM) has a unique position since it combines process conditions with membrane parameters. The aim of this work is to demonstrate the extension of the RSM to cove

In this paper the feasibility of combining pervaporation with conventional processes such as adsorption and steam stripping in a hybrid process to recover phenol from waste water is analysed taking technical and economical aspects into account. Compared to stand alone units it is found that hybrid processes based on pervaporation and conventional units can be an economic alternative for the meetin

An generalised engineering approach based on the analogy between mass and heat transfer is proposed to benchmark the shell-side mass transfer coefficient for axial flow in hollow fibre modules from low to moderate packing densities. The trends obtained by this approach are similar to those of correlations found in the literature and differences between the approaches are discussed. Furthermore, ef

The resistance-in-series model, used to describe the mass transfer through a membrane in pervaporation for binary systems, has been extended to include ternary and multi-component mixtures of different organic and inorganic compounds in aqueous solutions. The new model was used in a simulation including the membrane characteristics and the geometry of the pervaporation. Thus, the influence of proc

Genome wide association studies (GWAS) have mapped multiple independent cancer susceptibility loci to chr5p15.33. Here, we show that fine-mapping of pancreatic and testicular cancer GWAS within one of these loci (Region 2 in CLPTM1L) focuses the signal to nine highly correlated SNPs. Of these, rs36115365-C associated with increased pancreatic and testicular but decreased lung cancer and melanoma r

From 2012 to 2016 the drug industry donated over £57m (€65m; $73m) to UK patient organisations, with the annual sum more than doubling over the period. The funding benefited a small number of organisations and activities related to research and public involvement. The industry gave priority to commercially high profile conditions. Industry payment disclosures had limited transparency

Background: Deep learning convolutional neural networks (CNN) may facilitate melanoma detection, but data comparing a CNN's diagnostic performance to larger groups of dermatologists are lacking.Methods: Google's Inception v4 CNN architecture was trained and validated using dermoscopic images and corresponding diagnoses. In a comparative cross-sectional reader study a 100-image test-set was used (l

Meniscectomy is recognized as an important risk factor for the development of knee osteoarthritis (OA), a disease that traditionally has been considered as a simple "wear and tear" phenomenon. However, despite numerous reports, little evidence has been presented that a limited meniscal resection, compared with a more extensive resection, reduces the risk of OA by preserving meniscal function. Why?