Intraischemic moderate hypothermia generally protects the brain against ischemic cell death, while hypothermia instigated several hours into the reperfusion phase is considered to be less effective. Here we report the effect of hypothermia (32.5°-33.5°C) of 5-h duration, initiated at 2, 6, 12, 24 and 36 h into the recirculation phase following 10 min of transient cerebral ischemia, on ischemic neu

The effects of inhaled 1,1,1-trichloroethane (3500, 6000, and 7800 ppm) on behavior, local cerebral blood flow, and local cerebral glucose consumption were studied in awake rats. The effect of the solvent inhalation on the EEG pattern and local cerebral blood flow was also studied in paralyzed animals under N2O analgesia. Exposure of awake animals to 6000 ppm 1,1,1-trichloroethane induced a decrea

Objective - T cell immunoglobulin and mucin domain (Tim) proteins are expressed by numerous immune cells, recognize phosphatidylserine on apoptotic cells, and function as costimulators or coinhibitors. Tim-1 is expressed by activated T cells but is also found on dendritic cells and B cells. Tim-4, present on macrophages and dendritic cells, plays a critical role in apoptotic cell clearance, regula

Natural resources can have a powerful impact on the public budget but may also hinder the development of other sources of revenue, thus limiting the long-term development of fiscal capacity in resource-rich countries. This article evaluates both possible effects bycomparing the long-term evolution (1850s-1930s) of public revenues in Andean (Bolivia,Chile and Peru) and Nordic (Norway and Sweden) co

In the face of climate change, populations have two survival options − they can remain in situ and tolerate the new climatic conditions (“stay”), or they can move to track their climatic niches (“go”). For sessile and small-stature organisms like alpine plants, staying requires broad climatic tolerances, realized niche shifts due to changing biotic interactions, acclimation through plasticity, or

Diagnostic measurement of electric skin conductivity (ESC) called the Ryodoraku system was introduced in mid 1950s by Nakatani. As has been shown by Ziobro et al. in case of infantile cerebral palsy, changes of ESC may provide a valuable electrophysiological parameter for monitoring a therapy. In this study ESC was measured in asthmatic children treated with a bioelectronic unit VEGA-SELECT. Analy

In the setting of transplantation, T cells are deliberately depleted to prevent allograft rejection. However, this IL-7 activates the accelerated proliferation of effector memory T cells, which are the predominant mediators of graft rejection. Multipotent adult progenitor cells (MAPC) have been previously shown to modulate the response of T cells to IL-7, in vitro but not in vivo. Here, for the fi

Infection of orthopedic implants is a growing clinical challenge to manage due to the proliferation of drug-resistant bacterial strains. In this study, we aimed to investigate whether the treatment of implants with ceragenin-90 (CSA-90), a synthetic compound based on endogenous antibacterial peptides, could prevent infection in a novel rat model of periprosthetic joint infection (PJI) challenged w

BACKGROUND: Increasing life expectancy for people with an intellectual disability (ID) is resulting in more persons with cancer and a greater need for end-of-life (EoL) care. There is a need for knowledge of health care utilisation over the last year of life to plan for resources that support a high quality of care for cancer patients with ID. Therefore, the aims of the study were to compare (1) h

Artikelförfattaren gör en kronologisk genomgång av järtecken och historiska händelser med anknytning till Estland och Livland i kyrkoherden Joen Klints handskrivna Järteckenbok (bevarad i Linköpings Stiftsbibliotek). Klints anteckningar relateras till samtida idéhorisont (särskilt till Balthasar Russows livländska krönika, vilken tjänat som källa till en stor del av Klints anteckningar) och den mo

An asymptomatic Atrial Septal Defect (ASD) is often closed at the age of 3–5 years using a transcatheter or surgical technique. Symptomatic ASD or ASD associated with pulmonary hypertension (PHT) may require earlier closure, particularly in combination with other non-cardiac risk factors for PHT, but the indications for early closure and the potential risk for complications are largely unknown. Th

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies and is known for its high resistance and low response to treatment. Tumor immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Karyopherin alpha 2 (KPNA2), a member of the nuclear transporter family, is elevated in multiple human cancers and accelerates carcinogenesis. Howeve

Background: Multiple Acyl-CoA-Dehydrogenase deficiency (MADD) is an inherited metabolic disorder characterized by impaired oxidation of fatty acids and some amino acids. Methods: We were interested whether children with MADD could tolerate a prolonged low-intensity exercise test and if this test could have any additional diagnostic value. Therefore, we performed a maximal exercise test and a low-i

För att kunna nå målen i ämnet hem- och konsumentkunskap krävs det att eleverna kan klara av uppgifter med hög kognitiv svårighetsgrad. För läraren är stöttning, både i planerad och i tillfällig form, ett viktigt verktyg för att hjälpa eleverna att nå målen. Denna stöttning kan finnas i form av exempelvis rikliga tillfällen till interaktion, tydlig information kring arbetsmoment, samarbete över äm

While a broad spectrum of technologies is integrated in everyday life and routines, most research on ageing, health and technology has focused on attitudes toward and adoption of digital technologies including e-health, or home based monitoring systems. The aim of this study was to explore differences and similarities in attitudes and experiences with different types of technologies and developmen