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This thesis aimed to explore the binding pocket of galectin-8N and galectin-3C. Both structure-based drug design and fragment-based drug discovery were utilized in this project, exemplifying the benefits of the different approaches. Structural determination of the proteins in complex with both high affinity ligands, and small fragments was achieved through x-ray crystallography. The structures of

Breast cancer is the most common type of cancer worldwide with an estimate of 2.3 million new cases in 2020, and the number one cause of cancer-related deaths in women. While survival rates are high in many high-income countries, with a five year relative survival rate of 85% and more, the respective survival rates are poor in many middle- and low-income countries, with rates as low as 12% in Kyad

This study aims to examine Russian reflexive control within the information sphere in the context of the Russian aggression against Ukraine. In particular, it examines whether Russian publicly available official and non-official Telegram news channels use reflexive control measures in its communication to a Swedish- and English-speaking international audience regarding Swedish support for Ukraine

Following the continual degradation of climate, the issue of climate change has increasingly been integrated in world politics. The European Union has itself implemented climate policies to adverse the tendency. However, the union has also given rise to the principle of free movement, a concept tightly connected to the EU’s carbon intensive transport sector. Research has shown the need for the EU

Counterintelligence is the activities and efforts aimed at protecting the intelligence agency from the adversary. This study examines CIA counterintelligence during the Cold War with a focus on defensive counterintelligence. Using a case study of convicted spy Aldrich Ames, the study sets out to answer whether there were differences in status and resources between defensive and offensive counterin

Knowledge brokerage and science communication are roles prone to forming “certainty troughs” (MacKenzie, 1990) between scientists and science’s downstream consumers. This has been studied as pertaining to in particular the geoscience area of CO2/climate, with an eye for the security domain’s use of science’s knowledge vertical. As background, the areas of knowledge acquisition, undue politicizatio

The purpose of this study was to investigate how young people think about their chosen goals and the possibilities of reaching them, as well as whether they associate these goals and possibilities with internal and/or external circumstances. Six first- and third-year high school students were interviewed using a semi-structured interview guide. They were asked prepared questions and, depending on

Sepsis, a serious medical condition often leading to patients requiring intensive care, has prompted numerous scientists to employ mathematical techniques to aid in its diagnosis. This thesis uses logistic regression and a machine learning technique, XGBoost, to predict true sepsis (as opposed to sepsis mimics) and culture-positive sepsis (among true sepsis) in critical care using blood test resul

Writing a Renaissance: The New Negro and the path to a new Black nationalism 1917–1925 The New Negro: an Interpretation (1925), edited by the philosopher and critic Alain Locke, is regarded as a central text concerning the literary movement known as the Harlem Renaissance. Widely viewed as documenting the transition of Black American litterature into the age of modernism. The anthology sought to

The aim of this study is to investigate the construction of irregular migrants as a social problem and a security threat in the Swedish news press. Specifically, it examines discussions around the motion that obligates welfare actors to report encounters with irregular migrants to Swedish authorities. The study also investigates how the motion and the debaters are constructed in this debate. We ex

Syftet med detta arbeta är att bidra med kunskap som kan förebygga dis-kriminering av personer med funktionsnedsättning kopplade till använd-ning av automatiserade beslutsprocesser inom statliga myndigheters ären-dehantering, med fokus på beslutsprocesser på Försäkringskassan. Det finns många risker med helt eller delvis automatiserade beslutsprocesser som kan leda till missgynnande. Det finns åtgThe purpose of this work is to contribute knowledge aimed at preventing dis-crimination against individuals with disabilities. To the use of automated deci-sion-making processes within governmental agencies’ case handling, with a focus on decision-making processes at the Social Insurance Agency (Försäkringskassan). There are numerous risks associated with fully or par-tially automated decision-mak

En betydande del av befolkningen i Sverige är idag beroende av alkohol eller droger. Genom att göra en kvalitativ studie av fyra självbiografier, skrivna av före detta missbrukare av alkohol och narkotika, var syftet att undersöka hur grupper påverkar individer i olika sociala situationer. Viktiga faktorer för påverkan eller påtryckningar inkluderar både individens närmaste umgängeskrets och det s

Vilka värden som betraktas som viktiga i ett samhälle förändras över tid. Det gäller också i straffrätten. I uppsatsen inringas straffrättsliga värden, med ledning i intressen, som utifrån förarbeten och lagtext framstår som centrala. Ett skyddsintresse som fått en mer framskjuten position under den senare delen av nittonhundratalet är personlig integritet. I detta ligger anspråk på autonomi, frihThe values that are considered important in a society change over time. This also applies to criminal law. The paper identifies values, from interests, in criminal law that appear to be central based on the preparatory work and legal text. One protection interest that gained a more prominent position during the latter part of the twentieth century is personal integrity. This includes claims to aut

PCDD/Fs and dl-PCBs, or more commonly referred to as dioxin and dioxin like substances are compounds present in our surrounding environment. As some congeners of these have been shown to be toxic, they are regulated under the Stockholm Convention. As dioxins are persistent in biota and have lipophilic properties they are seen accumulating in lipid rich fish in the Baltic, one of the affected speci

De riktade ränteavdragsbegränsningsreglerna introducerades 2009 i inkomstskattelagen (IL) för att motverka skatteplanering mellan bolag inom samma intressegemenskap och skydda den svenska skattebasen. Reglerna har sedan dess ändrats två gånger varav den senaste versionen introducerades 2019. Huvudregeln i 2019 års regler är att ränteutgifter kopplade till en koncernintern skuld endast är avdragsgiThe Swedish interest deduction limitation rules were introduced in 2009 in the Income Tax Act (ITA) to counteract tax planning between companies within the same group and to protect the Swedish tax base. The rules have since been amended twice, with the latest version introduced in 2019. The main rule in the 2019 rules is that interest expenses related to an intra-group debt are only deductible in

The world is transitioning towards a renewable energy system to combat climate change and the wind power industry plays a key role in this shift. However, with the expansion of wind power concerns about its impact on local biodiversity have been raised. This thesis investigates the incentives, regulations, and challenges that are influencing biodiversity management in the wind power industry. Thro

This thesis examines the lack of reliable data and the comprehensive understanding regarding lethal violence in Sweden, especially when taking into consideration the hightened media focus on lethal shootings. This thesis aims to solve that by adding more nuance to the public knowledge, both regarding the good and the bad. By utilizing high-quality cause-of-death registry data from the Swedish Nati

Tau-leaping is an algorithm for model simulations most often used in kinetic chemistry. It was created to make simulations more efficient at the cost of some accuracy. However, its uses outside of chemistry are limited but could help make some model simulations more efficient. This study aimed to implement Tau-leaping and analyze it from a statistical perspective. The Lotka-Volterra prey-predator

This master case study delves into Hennessy's strategic efforts to dissociate itself from associations with the US hip hop community during the 1990s to the early 2000s in order to reclaim control over their brand. Authored by three master's students, the case study teaching notes provides insights of how students can solve the case of Hennessy's branding challenges and learn from the