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Children with hemophilia have a significantly higher risk of intracranial hemorrhage (ICH) compared to the normal population. Prophylaxis reduces the risk of ICH and earlier initiation of prophylaxis may now be feasible, especially in hemophilia A (HA). The aim of the study is to explore the potential for preventing ICH by earlier start of prophylaxis by assessing the natural course of ICH before

Background: Depression and suicidal behavior have been linked to increased blood-brain barrier (BBB) permeability. Platelet-derived growth factor receptor beta (PDGFR-β) is widely expressed in pericytes and promotes BBB integrity. Here, we investigated cerebrospinal fluid (CSF) levels of PDGFR-β in suicide attempters and healthy controls and correlated PDGFR-β to depression symptom severity. Metho

Aims The REDUCE-AMI trial showed that beta-blockers in patients with preserved left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI) had no effect on mortality or cardiovascular outcomes. The aim of this substudy was to evaluate whether global longitudinal strain (GLS) is a better prognostic marker than LVEF, and if beta-blockers have a beneficial effect in patients wit

Attosecond photoelectron interferometry based on the combination of an attosecond pulse train and a synchronized infrared field is a fundamental technique for the temporal characterization of attosecond waveforms and for the investigation of electron dynamics in the photoionization process. In this approach, the comb of extreme ultraviolet harmonics typically lies above the ionization threshold of

Introduction: Ambient air pollution and road traffic noise are stroke risk factors, but evidence on their potential joint effects remains limited. This study investigated the independent and joint associations of air pollution and road traffic noise on stroke incidence using both multiplicative and additive scales. Methods: We followed stroke incidence in ten cohorts in Sweden, Denmark, and Finlan

Objective Previous research on interprofessional learning in primary healthcare has been focused on students' learning in the encounter with the patient. However, the research is limited, and a review of the experiences of patients, students, and supervisors of interprofessional learning in primary healthcare is lacking. The focus of this scoping review is to describe the current knowledge and als

As novel, anti-amyloid therapies have become more widely available, access to timely and accurate diagnosis has become integral to ensuring optimal treatment of patients with early-stage Alzheimer's disease (AD). Plasma biomarkers are a promising tool for identifying AD pathology; however, several technical and clinical factors need to be considered prior to their implementation in routine clinica

Global biodiversity is rapidly declining due to habitat degradation and genomic erosion, highlighting the urgent need to monitor endangered species and their genetic health. Temporal genomics and ecological modelling offer finer resolution than single-Time-point measurements, providing a comprehensive view of species' recent and future trajectories. We investigated genomic erosion and environmenta

How does new technology impact labor market outcomes? We address this question by examining the adoption of electricity in Sweden during the early 20th century. Leveraging detailed individual-level data that covers the entire labor market and exogenous variation in electricity access driven by proximity to hydro-power plants, we estimate the impact of electrification on individual labor market out

Permanent ponds are key landscape units that supply various ecosystem services. Notably, the export of aquatic subsidies to land via emerging insects may significantly influence terrestrial food webs. Polyunsaturated fatty acids (PUFA), which enhance consumer fitness, are among the essential exported components. The patterns and drivers of dietary exports from ponds via insects remain poorly known

Chronic breathlessness is a common and distressing symptom, negatively impacting physical function and quality of life. Many individuals presenting with chronic breathlessness wait years for an explanatory diagnosis, leading to delays in accessing effective treatments and worse individual outcomes including premature mortality. In addition, delays to diagnosis are associated with increased healthc

The incidence of parameningeal infection (PI) is increasing in the context of therapy-induced immunosuppression. PI often presents with atypical symptoms, leading to delayed diagnosis and intervention, and can result in severe neurological sequelae. However, current understanding of PI remains limited due to a lack of basic research on host-pathogen interactions. Here, we first established a trans

I artikeln analyseras förfarandereglerna i den svenska tilläggsskattelagstiftningen och deras förenlighet med unionsrätten och Europakonventionen. Fokus ligger på aspekter kopplade till rapportering, sanktionsavgifter och potentiellt oskäliga skatteuttag. Särskild uppmärksamhet ägnas åt frågan om den förenklade tilläggsskatterapportens rättsliga status, risken för dubbelbestraffning i strid med ne

Lidar technology was utilized to non-destructively explore the diverse insect life in the Taï virgin forest of Côte d'Ivoire. This study employed an entomological Lidar scanned at different elevation angles, combined with traditional insect trapping at different canopy heights, to investigate the composition and spatial-temporal distribution of insects within the forest canopy. We detected stratif

This article presents a comprehensive database featuring the digitized, cleaned, geocoded, and linked data of the Swedish manufacturing censuses between 1863 and 1900. The data covers close to the universe of Swedish manufacturing activity and includes establishment-level information on workers, the sum of production value, and toll as output value. The article describes how the data was originall

The use of bio-based materials offers opportunities to mitigate the climate impacts of construction, with buildings potentially acting as carbon sinks. However, it remains unclear what a future bio-based construction sector will look like. One reason for this are diverse socio-technical visions for the use of bio-based construction materials. In this paper, we use discourse analysis across a compr

Combustion properties and combustion chemistry of ammonia (NH₃) are significantly different from those of hydrocarbons and thus require further investigation. NH₃ combustion with oxidizers different from the ambient air can reveal distinct chemistry of NOx formation, which, together with low reactivity, is one of the major obstacles in the direct deployment of ammonia as a practical fuel. In the p

Background: Studies have shown that women are asking for more knowledge and guidance about menopause. The professional competence of midwives encompasses menopause as a potential area of expertise. Midwives have good knowledge of women's health and are used to providing health advice. Aim: The aim was to examine midwives’ experiences of working with menopause counselling. Methods: Data were collec