Rationale: Galectin-3 (Gal-3) drives fibrosis during chronic lung injury, however, its role in acute lung injury (ALI) remains unknown. Effective pharmacological therapies available for ALI are limited; identifying novel concepts in treatment is essential. GB0139 is a Gal-3 inhibitor currently under clinical investigation for the treatment of idiopathic pulmonary fibrosis. We investigate the role

Diverse approaches such as oscillating gradients, tensor-valued encoding, and diffusion-relaxation correlation have been used to study microstructure and heterogeneity in healthy and pathological biological tissues. Recently, acquisition schemes with free gradient waveforms exploring both the frequency-dependent and tensorial aspects of the encoding spectrum b(ω) have enabled estimation of nonpara

This study tested for an association between early cancer-related biomarkers and low-to-moderate exposure to fumes from welding mild steel. Methods Male, non-smoking participants from southern Sweden were recruited and examined (N=338, 171 welders and 167 controls); of these, 78 welders and 96 controls were examined on two occasions six years apart. Exposure to welding fumes was evaluated by measu

To provide more integrated care, several countries have implemented the Flexible Assertive Community Treatment (FACT) model. However, this model does not guarantee full integration, especially in complex and fragmented service systems like in Norway. Hence, we investigated which barriers that might reduce the potential for integrated care in the Norwegian system, as described by staff in FACT team

This study explores the experiences of Swedish upper secondary school chemistry students working with a socioscientific issue about per- and polyfluoroalkyl substances (PFAS) in everyday products, and how they perceive that this teaching has influenced them in their role as citizens in a democratic society. Data collection has been carried out on several occasions over a period of one and a half y

Azo dyes are recalcitrant organic pollutants present in textile industry effluents. Conventional treatment methods to remove them come with a range of disadvantages. Nanoparticles and their nanocomposites offer more efficient, less expensive and easy to handle wastewater treatment alternative. Methods. In this study, nanoparticles of nickel oxide (NiO-NPs), copper oxide (CuO-NPs) and their nanocom

AMP-activated protein kinase (AMPK) activation is considered a useful strategy for the treatment of type 2 diabetes (T2D). It is unclear whether the expression and/or activity of AMPK in adipocytes is dysregulated in obesity. Also, the expression/activity pattern of AMPKβ isoforms, which are targets for AMPK activators, in adipocytes remains elusive. In this study we show that the two AMPKβ isofor

Results from the application of a new seismic technique for non-destructive testing of pavement layer moduli are presented. The method is based on the multichannel analysis of surface waves (MASW) method and multichannel simulation with one receiver (MSOR). The MSOR method uses one accelerometer (receiver), a light hammer (source), and a single-channel recording device to generate a simulated mult

The Baltic Sea is one of the fastest-warming marginal seas globally, and its temperature rise has adversely affected its physical and biochemical characteristics. In this study, forty years (1982–2021) of sea surface temperature (SST) data from the advanced very high resolution radiometer (AVHRR) were used to investigate spatial and temporal SST variability of the Baltic Sea. To this end, annual m

Background: Preeclampsia (PE) is a “multifactorial syndrome” in which ambient air pollution may contribute to the etiology of PE. However, the underlying mechanism of this association is not clearly elucidated. This dissertation aims at understanding the placental molecular mechanism underlying the relationship of prenatal exposure to ambient air pollution with preeclampsia and fetal growth by cha

Kyrkspirorna och tornen på Stockholms horisont blandar sig med radiosändningar som flyger ut över staden bredvid privatiserade våglängder, driver ner genom atmosfären och sjunker ner i det övergivna underjordiska telefonsystemet. Stockholm har byggnader som funnits där i århundraden, men är också full av den mest moderna och samtida arkitektur. Allt konkurrerar om sin plats i det kollektiva minnetThe towers of the Stockholm skyline twine with radio transmissions, flying out over the city, drifting down through the streets and sinking into the underground telephone system below. Stockholm has buildings that have been there for centuries, but is also full of modern and contemporary architectures, all jostling for their place in parallel collective memory. In taking the city up as a subject,

In this audio paper I will focus on two ideas. The first is the ephemeral city. The conscious re-imagining of the cityscape, from elements ranging from the historic to the fantastical, can effect an individual’s sense of place as much as the physical structures that comprise it. These imagined – or ephemeral – cities can be a way of coming to grips with an urban environment changing in rapid and dis