The ability to capture alterations in the genome or transcriptome by next-generation sequencing has provided critical insight into molecular changes and programs underlying cancer biology. With the rapid technological development in single-cell sequencing, it has become possible to study individual cells at the transcriptional, genetic, epigenetic, and protein level. Using single-cell analysis, an

While traditional forms of urban planning are oriented towards the future, the recent turn towards experimental and challenge-led urban developments is characterized by an overarching presentism. We explore in this article how an experimental approach to urban planning can consider the long-term through setting-up ‘conversations with a future situation.’ In doing so, we draw on a unique experiment

Background: Bark beetles are major pests of conifer forests, and their behavior is primarily mediated via olfaction. Targeting the odorant receptors (ORs) may thus provide avenues towards improved pest control. Such an approach requires information on the function of ORs and their interactions with ligands, which is also essential for understanding the functional evolution of these receptors. Henc

Over the last two decades, electrification has gained importance as a means to decarbonise the transport sector. As the number of Electric Vehicles (EVs) increases, it is important to consider broader system aspects as well, especially when deciding the type, coverage, size and location of the charging infrastructure required. This article proposes a new approach using agent-based simulations to a

Purpose: To translate and culturally adapt the Swedish version of the ‘Blue flags’ questionnaire into Dutch and to examine the validity and reliability aspects of the Dutch version. Methods: The ‘Blue flags’ questionnaire was translated and culturally adapted to the Dutch situation. A total of 58 participants filled in the first questionnaire at baseline and 51 participants filled in the second qu

Purpose: This study was designed to evaluate the performance of typically developing Swedish-speaking children on DYMTA (Dynamisk Motorisk Talbedömning), a Swedish dynamic motor speech assessment. Method: Participants were 94 children, 45 boys/49 girls (9/8 multilingual), with typical oral motor, speech, and language skills, between 37 and 106 months divided into five age-groups. They performed tw

High-performance polymer donors when paired with nonfullerene acceptors are mainly limited to flanking halogenated benzodithiophene (BDT)-based π-conjugated copolymers, which however involve complex synthetic procedures. Herein, a series of halogen-free polymer donors that link BDT moiety with two highly electron-deficient benzodithiophene-dione (BDD) and diketopyrrolopyrrole (DPP) units with vari

This article reviews the geology of the Sveconorwegian orogen in south Scandinavia and existing tectonic models for the Mesoproterozoic to Neoproterozoic Sveconorwegian orogeny. It proposes an updated geodynamic scenario of large, hot, long-duration continental collision starting at c. 1065 Ma between proto-Baltica and another plate, presumably Amazonia, in a Rodinia-forming context. An orogenic p

Three-dimensional growth of nanostructures can be used to reduce the threading dislocation density that degrades III-nitride laser performance. Here, nanowire-based hexagonal GaN microprisms with flat top and bottom c-facets are embedded between two dielectric distributed Bragg reflectors to create dislocation-free vertical optical cavities. The cavities are electron beam pumped, and the quality (

In Sweden, at the turn of the 20th century, the Social Democrats created a network of radically communal spaces. These deserve new attention as a usable past that can inform our own contentious times, especially as we contend with a pandemic that is upending our daily lives and political landscapes.

Polycyclic aromatic hydrocarbons (PAHs) are produced by anthropogenic activities, such as traffic and domestic heating. Due to their adverse effects to humans and natural habitats, the presence of PAHs in the environment needs to be monitored. Plants are known as natural accumulators of persistent organic pollutants (POPs) and can therefore be used for the monitoring of PAHs emitted into the envir