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Protein dynamics contribute to protein function on different time scales. Ultrafast X-ray diffraction snapshots can visualize the location and amplitude of atom displacements after perturbation. Since amplitudes of ultrafast motions are small, high-quality X-ray diffraction data is necessary for detection. Diffraction from bovine trypsin crystals using single femtosecond X-ray pulses was recorded

The aim of the dissertation is to explore how actors within the food value chain form meaningful relationships, practically and emotionally, with food and through food. It analyzes the making of these relations through the lens of organic, local and heritage food. It demonstrates that the impetus common to various food initiatives – such as organic, local and heritage food – is that they try to br

The Organic Consumer Association (OCA) in Iceland was established by domestic producers, importers, retailers and consumers. What separated this consumer association from conventional ones was that its founders included both organic producers and “middlemen” (importers, wholesalers and retailers). These same middlemen are often criticized for destroying valuable connections between producers and c

Objectives: The aim of this study was to evaluate the short-term safety and efficacy of transcatheter aortic valve replacement (TAVR) with the LOTUS Edge system. Background: The LOTUS Edge system was commercially re-released in April 2019. The authors report the first European experience with this device. Methods: A multicenter, single-arm, retrospective registry was initiated to evaluate short-te

This paper discusses unfortified thirteenth century palaces in Sweden. The palaces were unfortified already when built, and never became fortified before being abandoned. The palaces are analysed in relation to a power-grammar of architectural properties as well as the capitalization of the use of the past. It is argued that the absence of fortifications was a way for the medieval kings and royal

An agent is morally competent if she can respond to moral considerations. There is a debate about whether agents are open to moral blame only if they are morally competent, and Dana Nelkin’s “Psychopaths, Incorrigible Racists, and the Faces of Responsibility” is an important contribution to this debate. Like others involved in this dispute, Nelkin takes the case of the psychopath to be instructive

Bernard Williams (1929–2003) was one of the great philosophical figures of the second half of the twentieth century. This collection, devoted to Williams’s ethical thought, is divided into two sections. The chapters in the first section deal with Williams’s attempts to explore theoretical options beyond the confines of what he called “the morality system.” These chapters show how, through a critic

Objectives To investigate whether artificial intelligence (AI) can reduce interval cancer in mammography screening. Materials and methods Preceding screening mammograms of 429 consecutive women diagnosed with interval cancer in Southern Sweden between 2013 and 2017 were analysed with a deep learning–based AI system. The system assigns a risk score from 1 to 10. Two experienced breast radiologists

Model programs such as the ‘environmental protection model city’ have become an inherent part of China’s urban environmental governance. The role of these incentive schemes for promoting best practice, however, has been neglected so far. In this study, we show that model city programs raise the bar in terms of environmental standards. What is more, model cities have a positive impact on regional e

This study seeks to explain how Chinese state media bolster the use of visions in global internet governance. The empirical data for the article consists of 1,158 internet related articles published in the Global Times between 2009 and 2018. I develop a theoretical perspective that distinguishes between grand and strategic narratives. Based on a mixed-methods approach, I show that “internet sovere

Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains. These chains have intricate structural patterns based on the position of sulfate groups and uronic acid epimers, which dictate their ability to engage a large repertoire of heparan sulfate-binding proteins, including extracellular matrix prote

Protein-protein interactions are central in many biological processes, but they are challenging to characterize, especially in complex samples. Protein cross-linking combined with mass spectrometry (MS) and computational modeling is gaining increased recognition as a viable tool in protein interaction studies. Here, we provide insights into the structure of the multicomponent human complement syst

Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi

BACKGROUND: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk.METHODS: We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560