Background: Severe eosinophilic asthma is a high-burden disease. Mepolizumab has been effective in several randomized clinical trials. However, such success might not be applicable to patients treated in usual clinical practice. The objectives of this article are to evaluate the efficacy of mepolizumab in severe uncontrolled eosinophilic asthma under usual clinical practice, and to determine chara

Introduction: Decline in physical function varies substantially across older individuals due to several extrinsic modifiable factors such as dietary patterns, physical activity and social support. We aimed to determine the association of these factors and their interaction with mobility and muscle strength decline. Methods: We analyzed data from 1686 functionally healthy individuals aged 60 + from

This thesis focuses on the modelling and controlling of polymer electrolyte fuelcell (PEFC) systems. A system level dynamic PEFC model has been developedto test the system performance (output voltage, reactants gas partial pressures,and stack temperature) for different operating conditions. The simulation resultsare in good agreement with the experimental data, which indicates that thePEFC model i

The preschool years presents an important opportunity to support children’s social and emotional development. Social and emotional learning (SEL) programs in early childhood education and care (ECEC) have gained an increased interest due to its potential to improve child health and educational outcomes. We aimed to identify existing systematic reviews on universal, curriculum-based SEL interventio

Hypertension is the leading risk factor for premature death worldwide. The identification of modifiable causes of hypertension remains an imperative task. We aimed to investigate associations between 79 proteins implicated in cardiovascular disease and longitudinal blood pressure (BP) changes in three Swedish prospective cohorts. In a discovery phase, we investigated associations between baseline

I here argue that Ted Sider's indeterminacy argument against vaguenessin quantifiers fails. Sider claims that vagueness entails precisifications, but holds that precisifications of quantifiers cannot be coherently described: they will either deliver the wrong logical form to quantified sentences, or involve a presupposition that contradicts the claim that the quantifier is vague. Assuming (as does

The gaze behavior in sports and other applied settings has been studied for more than 20 years. A common finding is related to the “quiet eye” (QE), predicting that the duration of the last fixation before a critical event is associated with higher performance. Unlike previous studies conducted in applied settings with mobile eye trackers, we investigate the QE in a context similar to esport, in w

The study aims to understand the influence of environmental and lifestyle factors and more specifically the role of tobacco smoke–infused water (tuibur) on Helicobacter pylori infection. It was a cross-sectional study to measure the epidemiological risk factors associated with H. pylori infection among the tribal population in Northeast India. Endoscopic samples were collected from the antrum regi

IntroductionThe study was carried out to identify the polymorphisms in mitochondrial genes (ATPase and ND1) in type 2 Diabetes Mellitus (T2DM) from Mizo population and to correlate the involvement of demographic factors.FindingsIn the present study, 58 patients and 50 healthy volunteers were considered. The mutations observed were mostly base substitutions and were similar as reported for other po

For lossless universal source coding of memoryless sequences with an a priori unknown alphabet size (multialphabet coding), the alphabet of the sequence must be described as well as the sequence itself. Usually an efficient description of the alphabet can be made only by taking into account some additional information. We show that these descriptions can be separated in such a way that the encodin

This article explores the Egyptian state’s production of desired manhood and destruction of unwanted masculinities in relation to home and displacement through audio-focused analysis and a focus on sonic infrastructures. While sonic infrastructures can be used as a form of political control and violence, my work in Egypt also shows how people, through sound and sonic resistance, navigate and shape

The paper presents and briefly analyses some of the provisions of a Romanian legislative proposal which arrived at the Presidency for ratification twice, in slightly different forms, and which was rejected twice: the first time at the Presidency in October 2004, and the second at the Constitutional Court in July 2005. The proposal was finally dropped in February 2006. My intention here is to point

Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life immune development, and the gut microbiota can impact host physiology in various ways, such as through the production of metabolites. However, few breastmilk-dependent microbial metabolites mediating host–microbiota interactions are currently known. Here, we demonstrate that breastmilk-promoted Bifidobacter

Aim To explore the temporal impact of mild COVID-19 on need for primary and specialist health care services. Methods In all adults (≥20 years) tested for SARS-CoV-2 in Norway March 1st 2020 to February 1st 2021 (N = 1 401 922), we contrasted the monthly all-cause health care use before and up to 6 months after the test (% relative difference), for patients with a positive test for SARSCoV-2 (non-h