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Bcl-x L blocks mitochondrial multiple conductance channel activation and inhibits 6-OHDA-induced death in SH-SY5Y cells

Apoptosis is an active process that is regulated by different signalling pathways. One of the more important organelles involved in apoptosis regulation is the mitochondrion. Electron chain transport disruption increases free radical production leading to multiple conductance channel opening, release of cytochrome c and caspase activation. This death pathway can be blocked by anti-apoptotic member

Superoxide anions mediate veratridine-induced cytochrome c release and caspase activity in bovine chromaffin cells

1. Mitochondrial mechanisms involved in veratridine-induced chromaffin cell death have been explored. 2. Exposure to veratridine (30 micro M, 1 h) produces cytochrome c release to the cytoplasm that seems to be mediated by superoxide anions and that is blocked by cyclosporin A (10 micro M), MnTBAP (10 nM), catalase (100 IU ml(-1)) and vitamin E (50 micro M). 3. Following veratridine treatment, the

Efficient Predictor for Co-Simulation with Multistep Sub-System Solvers

An industrial model of a dynamic system is usually not just a set of differential equations. External inputs acting on the system are common, such as an external force acting on a body or wind pressing on a car. Update of these inputs needs to be handled by the numerical solver in an efficient way.In dynamical simulation, multistep methods are commonly used. A multistep method uses the solution hi

Human anaplastic thyroid carcinoma cells are sensitive to NK cell-mediated lysis via ULBP2/5/6 and chemoattract NK cells

PURPOSE: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive forms of cancer with no curative therapies available. To date, strategies to target ATC by immunotherapy have not been evaluated. We investigated whether ATC would be a suitable target for natural killer (NK) cell-based immunotherapy.EXPERIMENTAL DESIGN: We first established seven new cell lines from ATC tumors, three from p

The Gas6-Axl Interaction Mediates Endothelial Uptake of Platelet Microparticles

Upon activation, platelets release plasma-membrane derived microparticles (PMPs) exposing phosphatidylserine (PS) on their surface. The function and clearance mechanism of these MPs are incompletely understood. As they are pro-coagulant and potentially pro-inflammatory, rapid clearance from the circulation is essential for prevention of thrombotic diseases. The tyrosine kinase receptors Tyro3, Axl

Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy and is characterized by recurring structural genetic alterations. Previous studies of DNA methylation suggest epigenetic alterations may also be important, but an integrated genome-wide analysis of genetic and epigenetic alterations in ALL has not been performed. We analyzed 137 B-lineage and 30 T-lineage childhood ALL cases

Experimental evidence for ovarian hypofunction in sparrow hybrids

BackgroundPostzygotic isolation in the form of reduced viability and/or fertility of hybrids may help maintain species boundaries in the face of interspecific gene flow. Past hybridization events between house sparrows (Passer domesticus) and Spanish sparrows (P. hispaniolensis) have given rise to a homoploid hybrid species, the Italian sparrow (P. italiae). Although genetic incompatibilities are

Functional implications of the pH-trait distribution of the microbial community in a re-inoculation experiment across a pH gradient

We compared the influence of the microbial community composition and the environmental conditions for the functioning - microbial growth and respiration - and trait distribution - bacterial pH tolerance - of soil microorganisms across a pH gradient. Sterilised soil microcosms, including pH 4.1, 5.2, 6.7 and 8.3, with added plant litter were inoculated with unsterilized soil in a factorial design a

Harmonic morphisms from five-dimensional Lie groups

We consider 5-dimensional Lie groups equipped with a left-invariant Riemannian metric. On such groups we construct left-invariant conformal foliations with minimal leaves of codimension 2. These foliations produce complex-valued harmonic morphisms locally defined on the Lie group.

Producing anxiety in the neoliberal university

This paper presents a theoretical analysis of the neoliberal production of anxiety in academic faculty members in universities in Northern Europe. The paper focuses on neoliberalization as it is instantiated through audit and ranking systems designed to produce academia as a space of economic efficiency and intensifying competition. We suggest that powerful forms of competition and ranking of acad

The death of an emperor – Mohammad Reza Shah Pahlavi and his political cancer

Mohammad Reza Pahlavi, the Shah of Iran, was toppled in the Islamic Revolution of 1979. A year later he passed away from lymphoma, a disease he had secretly battled for several years, but still it remains unknown exactly when he was diagnosed with cancer, if he was aware of his condition and who close to him knew about his illness. Following his 1979 exile from Iran, physicians from numerous count

Fighting infectious disease: Evidence from Sweden 1870-1940

Even more than in developing countries today, public health strategies to fight infectious disease in the past focused on the prevention of new infections by stopping their spread. These strategies were motivated by new insights into the causes of disease and the modes of transmission in the mid-nineteenth century. By combining longitudinal individual-level data on 17,000 children in a rural/semi-

Assessment of breast reconstruction with DIEP flaps

Reconstruction with a Deep Inferior Epigastric Perforator (DIEP) flap is considered to be the first choice forautologous breast reconstruction. Skin and fat are transplanted from the lower abdomen to the chest were theblood vessels are reconnected through microsurgery. A total of 309 patients with unilateral DIEP flap and 23patients with expander prosthesis (EP) reconstructions were included in th

Recognising health care assistants' prior learning through a caring ideology

This article critically appraises a process of recognising prior learning (RPL) using analytical tools from Habermas' theory of communicative action. The RPL process is part of an in-service training program for health care assistants where the goal is to become a licensed practical nurse. Data about the RPL process were collected using interviews and observations. Through appraising RPL as a soci