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A series of O2 and O3-derivatized methyl beta-d-talopyranosides were synthesized and evaluated in vitro as inhibitors of the galactose-binding galectin-1, -2, -3, -4 (N- and C-terminal domains), 8 (N-terminal domain), and 9 (N-terminal domain). Galectin-4C and 8N were found to prefer the d-talopyranose configuration to the natural ligand d-galactopyranose configuration. Derivatization at talose O2

The title of this special issue, Gesture and SLA: Toward an Integrated Approach, stems in large part from the idea known as integrationism, principally set forth by Harris (2003, 2005), which posits that it is time to “demythologize” linguistics, moving away from the “orthodox exponents” that have idealized the notion of language. The integrationist approach intends a view that focuses on communic

The measurement of subtle morphologic beat-to-beat variability in the electrocardiogram (ECG)/vectorcardiogram (VCG) is complicated by the presence of noise which is caused by, e.g., respiration and muscular activity. A method was recently presented which reduces the influence of such noise by performing spatial and temporal alignment of VCG loops. The alignment is performed in terms of scaling, r

Abstract not available

Fishing expedition and the Nordic legal systems on discovery and disclosure

The report summarises the project Design based on quantitative risk. The project has been divided into five parts; model uncertainty, fire statistics, design values based on reliability index beta method, quantitative risk analysis and cost optimisation. The report gives a short description on all parts and refers to the more detailed reports from the project. In total 16 publications have been pr

Purpose: The detection of malignant tumours relies on a variety of diagnostic procedures including X-ray images and, for hollow organs, endoscopy. The purpose of this study was to present a new technique for non-invasive tumour detection based on tissue fluorescence imaging. Material and Methods: A clinically adapted multi-colour fluorescence system was employed in the real-time imaging of maligna

Jesper Svenbro samtalar med sociologen Lena Lindgren om sin hemstad Landskrona och om tidens och platsens roll för vad som kan sägas och tänkas

Although Chinese journalists are not able to create their own independent organisations, they are engaging in informal networking on-line and off-line that has created a strong sense of community among investigative journalists in particular. Through sharing experiences, stories, and struggles, journalists create a collective identity and define their roles in society. Earlier studies of Chinese j

Carotid surgery prevents recurrent stroke in patients with symptomatic tight stenosis of the carotid artery. The Swedish Carotid Surgery Monitoring Registry seeks to promote selection of patients with significant spontaneous risk for recurrent stroke, with an eye toward expediting evaluation and minimizing surgical complications. To this end, professionals at participating hospitals are informed a