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Deoxyhypusine synthase (DHS) catalyzes the rate-limiting step of hypusination, a unique post-translational modification of eukaryotic translation factor 5 A (eIF5A). While DHS activity plays a critical role in both normal cellular processes and disease development, the lack of specific molecular tools has hindered detailed studies of this enzyme and the hypusination pathway in general. Existing in

Articles pose a particular challenge to second-language learners whose first language does not have them. Variability in article production in these learners is often explained in terms of first-language influence, but there are also suggestions that frequency-biased regularities in the target language itself might play a role. While most second-language research on articles has focused on English

While Generative Artificial Intelligence (GAI), particularly tools powered by Large Language Models (LLMs), offer benefits in teaching and learning, they also raise critical concerns about academic integrity, fairness in examinations d ue to their potential for generating educational content. This evolving landscape requires higher education institutions to rethink their assessment models, ensurin

Rapidly evolving academic and professional environments require essential skills such as communication, collaboration, creativity and critical thinking, which are not typically learned and assessed explicitly in formal education. These skills encompass a significant part of the competencies and are increasingly valued in an AI-driven workforce because they cannot be easily replicated by machines.

Denna bok ger ett helhetsperspektiv över hur redovisning används i samband med värdering av och kreditgivning till företag. I boken presenteras metoder för beräkning och analys av ett stort antal nyckeltal baserade på redovisning.Vi lyfter även fram de faktorer som kan påverka redovisningens användbarhet samt hur det praktiskt kan gå till att bedöma kvalitet i redovisning. Boken ger läsaren kunska

Age estimation based on the dentition of animal remains is one of the most important methods used for analysis of the demography of past as well as contemporary animal populations by zooarchaeologists and wild game biologists (Wagenknecht 1967; Silver 1969; Morris 1972; Wilson et al. 1982). By constructing age profiles from faunal remains it is possible to study hunting of wild boar and pig husban

Background and purpose: Accurate grading and genotyping of gliomas are critical for tailoring personalized therapeutic strategies and predicting patient outcomes. This study investigates the potential of 5T glutamate chemical exchange saturation transfer (GluCEST) imaging in differentiating glioma grades and predicting pivotal molecular biomarker status. Methods: We first validated the specificity

Silk fibres derive their exceptional properties from hierarchical protein organisation, yet the molecular pathways that guide this structural transformation remain poorly resolved. During regenerated silk fibroin gelation under biomimetic gradual acidification, we identify a stepwise assembly pathway comprising nanoscale clustering, domain growth within clusters, and mesoscale network formation. T

**Mindre data, bättre mat: Konsten att gissa rätt med statistik** Att ställa om till hållbar mat är dyrt och riskabelt. Företag förlitar sig på smakpaneler, men med få provsmakare blir resultaten ofta osäkra gissningar. Detta examensarbete visar att avancerad sannolikhetslära kan vaska fram guld ur små datamängder. Men nyckeln till framgång var oväntad: för att fatta bättre beslut måste vi våga tConsumer sensory panels are the gold standard for evaluating food products, yet they often suffer from small sample sizes and sparse, ordinal data. Standard frequentist methods for analyzing this data (e.g. ANOVA, McNemar's test) often violate assumptions or lack statistical power. This thesis evaluates the efficacy of Bayesian Hierarchical Models (BHMs) with cumulative link likelihoods for an

Poor postoperative outcomes following colon cancer (CC) resection are influenced by multiple factors, including both patient-related characteristics as well as surgeon-related factors. However, the influence of surgical specialization, surgeon resection volume and surgeon gender on patient’s postoperative out- come, after complex procedures such as emergency CC resection, remains incompletely unde

The demographic development suggests a dramatic growth in the number of elderly patients undergoing surgery in Europe. Most red blood cell transfusions (RBCT) are administered to older people, but little is known about perioperative transfusion practices in this population. In this secondary analysis of the prospective observational multicentre European Transfusion Practice and Outcome Study (ETPO

BackgroundIt is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time–weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTW with intraoperative adverse events.MethodsPos

The 244Pu(48Ca,xn)292-xFl reaction was investigated at Lawrence Berkeley National Laboratory's 88 Inch Cyclotron using the Berkeley Gas-filled Separator (BGS), the newly installed SuperHeavy RECoil (SHREC) detector, along with an upgraded digital electronics and data acquisition system. Seven decay chains were observed starting with an evaporation residue (EVR) followed by a single α decay and a s

Background: The 2015 Lancet Commission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system streng

BackgroundSurgical services were poorly prepared for the COVID-19 pandemic, leading to widescale disruption to elective activity. This study aimed to identify actionable priorities to strengthen pandemic preparedness of surgical and hospital systems.MethodsThis study pooled data from three international, prospective cohort studies including patients who had a positive SARS-CoV-2 test result in the