Objectives/Hypothesis: Data from patients registered for myringoplasty during 2002 to 2012 in the Swedish National Quality Registry for Myringoplasty. Study Design: Both conventional myringoplasty and fat-graft techniques were used aimed at healing the tympanic membrane in noninfected ears. Methods: Analysis was performed on data in a national database collected from 32 ear, nose, and throat clini

The delivery of immunomodulators directly into the tumor potentially harnesses the existing antigen, tumor-specific infiltrating lymphocytes, and antigen presenting cells. This can confer specificity and generate a potent systemic anti-tumor immune response with lower doses and less toxicity compared to systemic administration, in effect an in situ vaccine. Here, we test this concept using the nov

Linked data is one of the most successful practices in semantic web, which has led to the opening and interlinking of data. Though many agents (mostly academic organizations and government) have published a large amount of linked data, numerous agents such as private companies and industries either do not have the ability or do not want to make an additional effort to publish linked data. Thus, fo

Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD), where its role and mechanism of action remain unknown. We have previously established that the membrane receptor FGFR2 drives LUAD progression through aberrant protein-protein interactions mediated via its C-terminal proline-rich motif. Here we report that the N-terminal ankyrin repeats of TRPA1 direct

Our presentation builds on a research project on the emergence of medical genetics and genetic counselling in Sweden 1940-1980. During our study, we have been able to track some aspects of biological, or eugenic, citizenship throughout this period.In Sweden, a rudimentary form of genetic counselling can be tracked within the context of state-controlled eugenics, namely in some applications of the Our presentation builds on a research project on the emergence of medical genetics and genetic counselling in Sweden 1940-1980. During our study, we have been able to track some aspects of biological, or eugenic, citizenship throughout this period.In Sweden, a rudimentary form of genetic counselling can be tracked within the context of state-controlled eugenics, namely in some applications of the

This paper analyses the role of regional context on innovation persistency of firms. Using the Community Innovation Survey in Sweden, we have traced firms' innovative behaviour from 2002 to 2012, in terms of four Schumpeterian types of innovation: product, process, organizational, and marketing. Controlling for an extensive set of firm-level characteristics, we find that certain regional character

Disease-modifying treatments remain an unmet medical need in Parkinson's disease (PD). Such treatments can be operationally defined as interventions that slow down the clinical evolution to advanced disease milestones. A treatment may achieve this outcome by either inhibiting primary neurodegenerative events ("neuroprotection") or boosting compensatory and regenerative mechanisms in the brain ("ne

We have seen a considerable effort in colloid sciences to copy Nature’s successful strategies to fabricate complex functional structures through self-assembly. This includes attempts to design colloidal building blocks and their intermolecular interactions, such as creating the colloidal analogs of directional molecular interactions, molecular recognition, host-guest systems, and specific binding.

The authors report a method to achieve Al-Al Ox -Al tunnel junctions with high specific resistance in a controlled manner using a double oxidation technique. The technique is based on the standard method for oxidation repeated on an additional Al layer. The tunnel junctions were characterized with standard methods, such as comparison of room temperature resistance with liquid helium resistance and

Cross-correlations between inter-annual summer rainfall time series (June to August: JJA) for arid Mongolia and global sea surface temperatures (GSST) were calculated for prediction purposes. Prediction of summer rainfall for four vegetation zones, Desert Steppe (DS), Steppe (ST), Forest Steppe (FS), and High Mountain (HM) using GSSTs for time lags of 5, 6, and 7 months prior to JJA rainfall was e

Sand grains from Quaternary glacial, aeolian and fluvial deposits in the Mazovian Lowland, central Poland, were examined to characterize the effects of different Quaternary processes on sand-grain surfaces that experienced repeated cycles of intense polar-desert-like conditions during the Middle and Late Pleistocene. A cold, dry and windy periglacial environment prevailed here at least twice betwe

Importance: Active surveillance is an important option to reduce prostate cancer overtreatment, but it remains underutilized in many countries. Models from the United States show that greater use of active surveillance is important for prostate cancer screening to be cost-effective.Objectives: To perform an up-to-date, nationwide, population-based study on use of active surveillance for localized

To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLADRB5 (odds ratio (

Although, for current laser pulse energies, the weakly nonlinear regime of laser wakefield acceleration is known to be the optimal for reaching the highest possible electron energies, the capabilities of upcoming large laser systems will provide the possibility of running highly nonlinear regimes of laser pulse propagation in underdense or near-critical plasmas. Using an extended particle-in-cell