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Review article : exposure to microbes and risk of coeliac disease

Background: Coeliac disease is an immune-mediated intestinal disease characterised by lifelong intolerance to dietary gluten in genetically predisposed individuals. Microbial factors including infections or bacterial microbiota have long been suspected to be involved in the aetiology, but the scientific literature on the topic is scattered and heterogeneous. Aims: To review human observational stu

Value of treatment by comprehensive stroke services for the reduction of critical gaps in acute stroke care in Europe

Stroke is the second leading cause of death and dependency in Europe and costs the European Union more than €30bn, yet significant gaps in the patient pathway remain and the cost-effectiveness of comprehensive stroke care to meet these needs is unknown. The European Brain Council Value of Treatment Initiative combined patient representatives, stroke experts, neurological societies and literature r

From iPS Cells to Rodents and Nonhuman Primates : Filling Gaps in Modeling Parkinson's Disease

Parkinson's disease (PD) is primarily known as a movement disorder because of typical clinical manifestations associated with the loss of dopaminergic neurons in the substantia nigra. However, it is now widely recognized that PD is a much more complex condition, with multiple and severe nonmotor features implicating additional brain areas and organs in the disease process. Pathologically, typical

Effects of blood parasite infections on spatiotemporal migration patterns and activity budgets in a long-distance migratory passerine

How blood parasite infections influence the migration of hosts remains a lively debated issue as past studies found negative, positive, or no response to infections. This particularly applies to small birds, for which monitoring of detailed migration behavior over a whole annual cycle has been technically unachievable so far. Here, we investigate how bird migration is influenced by parasite infect

Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of

Att göra många till en – om populismens logik

Den här artikeln introducerar Ernesto Laclaus teori om populism för den skan-dinaviska retorikforskningen i syfte att adressera en befintlig brist på begrepps liga resurser för att analysera populistiska artikulationer. Laclaus teori om populism syftar till att förklara de retoriska processer inneboende i varje politisk kamp såväl som att förstå konfliktdimensionen som konstitutiv för demokratisk po

Gradient corrections for reference dosimetry using Farmer-type ionization chambers in single-layer scanned proton fields

Purpose: The local depth dose gradient and the displacement correction factor for Farmer-type ionization chambers are quantified for reference dosimetry at shallow depth in single-layer scanned proton fields. Method: Integrated radial profiles as a function of depth (IRPDs) measured at three proton therapy centers were smoothed by polynomial fits. The local relative depth dose gradient at measurem

Tactical avoidance of statistics? – How students choose methods in writing theses in interdisciplinary higher education programmes

Eldh discusses the challenges in teaching quantitative methods, in this case statistics, in interdisciplinary courses with mixed methods where both qualitative and quantitative methods are taught. Despite this, most students tend to choose to use qualitative methods in their thesis research and the author researches why this is the case. Literature suggests that students often find statistics cour

ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children

Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease. The diagnosis is made using evaluated clinical criteria. Disease activity and burden are best measured with a composite score, assessing both objective and subjective symptoms, such as SCORing Atopic Dermatitis (SCORAD). AD management must take into account clinical and pathogenic variabilities, the patient’s age and a

Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time : An IMI-DIRECT study

Aim: To examine the hypothesis that, based on their glucose curves during a seven-point oral glucose tolerance test, people at elevated type 2 diabetes risk can be divided into subgroups with different clinical profiles at baseline and different degrees of subsequent glycaemic deterioration. Methods: We included 2126 participants at elevated type 2 diabetes risk from the Diabetes Research on Patie

New World geometrid moths (Lepidoptera: Geometridae) : Molecular phylogeny, biogeography, taxonomic updates and description of 11 new tribes

We analysed a molecular dataset of 1206 Geometroidea terminal taxa. In this paper we focus on New World taxa, with 102 Nearctic terminal taxa (97 of which have not previously been subject to molecular phylogenetic analysis) and 398 Neotropical terminal taxa (375 not previously analysed). Up to eleven molecular markers per specimen were included: one mitochondrial (COI) and ten proteincoding nuclea

Molecular phylogeny of Sterrhinae moths (Lepidoptera: : Geometridae): towards a global classification

A multigene phylogenetic study was carried out to test current, mostly morphology-based hypotheses on Sterrhinae phylogeny with additional material included from further geographical areas and morphologically different lineages. A maximum likelihood analysis (11 molecular markers and 7665 bp) was conducted on 76 species and 41 genera using iq-tree software. The resulting phylogenetic hypothesis is

Species delimitation and evolutionary relationships among Phoebis New World sulphur butterflies (Lepidoptera, Pieridae, Coliadinae)

The most accepted taxonomic treatment of the New World sulphurs of the genus Phoebis Hübner, [1819] recognizes 16 species including those in the current synonyms Aphrissa and Rhabdodryas. This total conflicts with the results of several recent pierid DNA barcode studies across the Neotropics. We used a five-locus dataset to carry out species delimitation analyses using the coalescence-based method

Association between anthropometry and lifestyle factors and risk of B-cell lymphoma : An exposome-wide analysis

To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 part

Depicting the Ethereal, Part I: Visual Art and Psi

The turn from figurative art to the depiction of internal experiences opened the door for artists to represent anomalous experiences and ostensible psi phenomena. Various studies have described how Abstract art was influenced by Occultism, but there were other important influences. They include scientific theories of the ether and hypergeometric dimensions, the development of technological advance