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Human Primary Bone Marrow Mesenchymal Stromal Cells and Their in vitro Progenies Display Distinct Transcriptional Profile Signatures

Bone marrow mesenchymal stromal cells (BM-MSCs) are a rare population of cells that gives rise to skeletal tissues and the hematopoietic stroma in vivo. Recently, we have demonstrated that BM-MSCs fulfill stringent in vivo stem cell criteria when propagated as non-adherent mesenspheres but not as adherent-cultured cells. Motivated by these profound functional differences, the current study aimed t

Simulated sample heating from a nanofocused X-ray beam

Recent developments in synchrotron brilliance and X-ray optics are pushing the flux density in nanofocusing experiments to unprecedented levels, which increases the risk of different types of radiation damage. The effect of X-ray induced sample heating has been investigated using time-resolved and steady-state three-dimensional finite-element modelling of representative nanostructures. Simulations

Transport and excitations in a negative-U quantum dot at the LaAlO3/SrTiO3 interface

In a solid-state host, attractive electron-electron interactions can lead to the formation of local electron pairs which play an important role in the understanding of prominent phenomena such as high T c superconductivity and the pseudogap phase. Recently, evidence of a paired ground state without superconductivity was demonstrated at the level of single electrons in quantum dots at the interface

Substantial decline of Northern European peatland bird populations : Consequences of drainage

Northern European peatlands are important habitats for biological conservation because they support rich biodiversity and unique species compositions. However, historical management of peatland habitats has had negative consequences for biodiversity and their degradation remains a major conservation concern. Despite increasing awareness of the conservation value of peatlands, the statuses and ecol

Clean water technologies and urban mortality in Sweden 1885-1925

Using a newly digitised historical dataset on clean water technologies in Swedish cities, this study tries to find the causal effect (and the magnitude of this effect) of the introduction of clean water technology on mortality in urban areas. Using urban mortality data on a county level, and clean water access data on city level, both OLS, fixed effects, and difference-in-differences models are tr

Field trials with in-car speed limiter

Within the framework of the EU-financed project MASTER field trials with in-car speed limiter were carried out in three “region-typical” countries: Sweden, the Netherlands, and Spain. The speed limiter is an active gas pedal which provides a gas pedal counter-force whenever the driver tries to depress the pedal beyond a pre-set speed limit. Twenty subjects per country drove two times along the tes

Performance evaluation of complex fenestration systems

It is known that shading systems often combined with solar control glasses are used to avoid glare and overheating at expenses of daylight. In Dynamic Thermal Modelling tools, there is no assessment method where the shading use is expressed when predicting the building performance. Furthermore, literature often refers to studies where complex fenestration systems are optimized for specific cases.

Bi-directional algebraic graphic statics

A pre-existing algebraic graphic statics method is extended to allow for interactive manipulations of the force diagram, from which an updated form diagram is determined. Newton's method is used to solve a set of non-linear equations, and the required Jacobian matrix is derived. Additional geometric constraints on the form diagram are introduced, and methods for improving the robustness of the met

Bi-directional plasticity : Rotifer prey adjust spine length to different predator regimes

Numerous prey organisms, including many rotifers, exhibit inducible defensive plasticity, such as spines, in response to predators. Here, we test the hypothesis that prey modify their defence response to different predator sizes with a bi-directional adjustment in spine length. First, we show experimentally, that large-sized predators induce a reduction in prey spine length. Second, we conducted a

Cellobiose dehydrogenase : Insights on the nanostructuration of electrodes for improved development of biosensors and biofuel cells

Cellobiose dehydrogenase (CDH) is a versatile bioelectrocatalyst lately at focus due to its sugar oxidising properties in combination with its inherent ability for direct electron transfer communication with electrodes making it possible to be used in bioanodes in the enzymatic fuel cells (EFCs), self-powered biosensors, and biosupercapacitors. During the last 20 years, many new nanomaterials and

Everyday life after a radical prostatectomy – A qualitative study of men under 65 years of age

Purpose The purpose of this study was to illuminate how men under 65 years of age experience their everyday Life one year or more after a radical prostatectomy for localised prostate cancer. Method Interviews with 19 men aged under 65 were performed 12–18 months after their radical prostatectomy. The interviews were analysed using a thematic content analysis. Results The analysis of the interviews