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PURPOSEAdjuvant radiotherapy (RT) is used for women with early-stage invasive breast cancer treated with breast-conserving surgery. However, some women with low risk of recurrence may safely be spared RT. This study aimed to identify these women using a molecular-based approach.METHODSWe analyzed two randomized trials of women with node-negative invasive breast cancer to ± RT following breast-cons

Direct oral anticoagulants (DOACs) used in nonvalvular atrial fibrillation (NVAF) are dose-reduced in elderly and patients with impaired renal function. Only reduced dose dabigatran is concluded as having similar stroke risk reduction and lower risk of major bleeding than warfarin in the pivotal studies. In clinical practice, reduced dose is prescribed more often than expected making this an impor

In this research project, the measurements of the ultrasonic P- and S-waves and seismic cone penetration testing (CPT) were applied to identify subsurface conditions and properties of clayey soil stabilized with lime/cement columns in the Stockholm Norvik Port, Sweden. Applied geophysical methods enabled to identify a connection between the resistance of soil and strength in the stabilized columns

This chapter discusses fundamental considerations related to the measurement of knowledge of multiword items (MWI). Central concepts like validity and reliability are accounted for, as are steps for linking theoretical and operational definitions with scoring procedures. Next, different approaches for MWI measurement are presented. This includes an account of traditional pencil-and-paper test form

Shell galaxies make a class of tidally distorted galaxies, characterized by wide concentric arc(s), extending out to large galactocentric distances with sharp outer edges. Recent observations of young massive star clusters in the prominent outer shell of NGC 474 suggest that such systems host extreme conditions of star formation. In this paper, we present a hydrodynamic simulation of a galaxy merg

Both plasma tau phosphorylated at threonine-181 (pTau181) and tau PET show potential for detecting Alzheimer’s disease (AD) pathology and predicting clinical progression. In this study, we performed a head-to-head comparison between plasma pTau181 and tau PET along the AD continuum. Methods: We included participants from the Amsterdam Dementia Cohort who underwent 18F-flortaucipir (tau) PET and ha

Purpose: Co-morbidities are common in chronic obstructive pulmonary disease (COPD) and are associated with increased morbidity and mortality. The aim of the present study was to explore the prevalence of several comorbid conditions in severe COPD, and to investigate and compare their associations with long-term mortality. Methods: In May 2011 to March 2012, 241 patients with COPD stage 3 or 4 were

OBJECTIVE: To summarize the effectiveness of management strategies and rehabilitation approaches for knee joint structural and molecular biomarker outcomes following anterior cruciate ligament (ACL) and/or meniscal tear. DESIGN: Intervention systematic review. LITERATURE SEARCH: We searched the MEDLINE, Embase, CINAHL, CENTRAL, and SPORTDiscus databases from their inception up to November 3, 2021.

High-order harmonic generation (HHG) provides scalable sources of coherent extreme ultraviolet radiation with pulse duration down to the attosecond time scale. Efficient HHG requires the constructive interplay between microscopic and macroscopic effects in the generation volume, which can be achieved over a large range of experimental parameters from the driving field properties to those of the ge

The specific angular momenta (j J/M) of stars (j∗), gas (jgas), baryons as a whole (jb) and dark matter haloes (jh) contain clues of vital importance about how galaxies form and evolve. Using one of the largest samples of disc galaxies (S0-BCD) with high-quality rotation curves and near-infrared surface photometry, we perform a detailed comparative analysis of j that stretches across a variety of

Finding new sustainable means of diagnosing and treating diseases is one of the most pressing issues of our time. In recent years, several endogenous peptides have been found to be both excellent biomarkers for many diseases and to possess important physiological roles which may be utilized in treatments. The detection of peptides has been facilitated by the rapid development of biological mass sp

We introduce two families of criteria for detecting and quantifying the entanglement of a bipartite quantum state of arbitrary local dimension. The first is based on measurements in mutually unbiased bases and the second is based on equiangular measurements. Both criteria give a qualitative result in terms of the state's entanglement dimension and a quantitative result in terms of its fidelity wit

In this paper, we study how the distributional preferences of planners and the public diverge in the context of national infrastructure planning. To do so, we surveyed a sample of 323 planners working at the Swedish Transport Administration and 2,108 members of the Swedish public. The most striking difference is that planners place a relatively higher value on aggregate benefits than the public. P

Importance: Blood phosphorylated tau (p-tau) and amyloid-β peptides (Aβ) are promising peripheral biomarkers of Alzheimer disease (AD) pathology. However, their potential alterations due to alternative mechanisms, such as hypoxia in patients resuscitated from cardiac arrest, are not known. Objective: To evaluate whether the levels and trajectories of blood p-tau, Aβ42, and Aβ40 following cardiac a

This paper addresses the weak signal detection problem in a massive colocated multiple-input multiple-output (MIMO) radar. To cope with the sheer amount of data produced by the large-scale antennas, a low-bit quantizer is introduced in the sampling process to enable both for hardware limitations and a high detection performance. The generalized likelihood ratio test (GLRT) detector is proposed for

The electrical control of a material's conductivity is at the heart of modern electronics. Conventionally, this control is achieved by tuning the density of mobile charge carriers. A completely different approach is possible in Mott insulators such as Ca2RuO4, where an insulator-to-metal transition (IMT) can be induced by a weak electric field or current. While the driving force of the IMT is poor

Since its public release in November 2022, ChatGPT has gained a widespread attention and received mixed responses in the academia. Promising applications of ChatGPT in university education has been suggested; however, several concerns were raised. The aim of this descriptive study was to investigate the pros and cons of ChatGPT use in medical, dental, pharmacy, and public health education. Based o

Background: Pain is a common feature of hemophilia, but prevalence of depression and anxiety is less studied. Registry data on prescription drugs can provide an objective measure of the magnitude of these complications. Objectives: To identify treatment patterns of prescribed pain, antidepressant, and antianxiety medications compared with those of matched controls in 4 Nordic countries. Methods: T

Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bidirectional mechanical exchange is crucial for many cell functions, it remains poorly understood. Key challenges are that the majority of available matrices for such studies, either natural or synthet

Current pulse driven Néel vector rotation in metallic antiferromagnets is one of the most promising concepts in antiferromagnetic spintronics. We show microscopically that the Néel vector of epitaxial thin films of the prototypical compound Mn2Au can be reoriented reversibly in the complete area of cross shaped device structures using single current pulses. The resulting domain pattern with aligne