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Experimental design trade-offs for gene regulatory network inference: An in silico study of the yeast Saccharomyces cerevisiae cell cycle

Time-series of high throughput gene sequencing data intended for gene regulatory network (GRN) inference are often short due to the high costs of sampling cell systems. Moreover, experimentalists lack a set of quantitative guidelines that prescribe the minimal number of samples required to infer a reliable GRN model. We study the temporal resolution of data vs. quality of GRN inference in order to

Linear Dynamic Network Reconstruction from Heterogeneous Datasets

This paper addresses reconstruction of linear dynamic networks from heterogeneous datasets. Those datasets consist of measurements from linear dynamical systems in multiple experiments subjected to different experimental conditions, e.g., changes/perturbations in parameters, disturbance or noise. A main assumption is that the Boolean structures of the underlying networks are the same in all experi

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A presentation of the results and experiences from a PhD- and excavation project in 1983 concerning the medieval cultural landscape of Bornholm.

Proof of Concept : Typesetting of Research in the Academic Publishing Industry

The production, reading and correcting of article proofs is a highly important part of scholarly publishing, and the proof of an article is the only place where researcher, journal production team and publisher come together, directly or indirectly. Yet, the proof process is rarely examined or discussed, and scholars seem to regard it as something separated from the research process. This paper waThe production, reading, and correcting of article proofs is a highly important part of scholarly publishing, and the proof of an article is the only place where researcher, journal production team, and publisher come together, directly or indirectly. Yet, the proof process is rarely examined or discussed, and scholars seem to regard it as something separated from the research process. This paper

Rapid imaging of intravenous gadolinium-based contrast agent (GBCA) entering ventricular cerebrospinal fluid (CSF) through the choroid plexus in healthy human subjects

BACKGROUND: Pathways for intravenously administered gadolinium-based-contrast-agents (GBCAs) entering cerebrospinal-fluid (CSF) circulation in the human brain are not well-understood. The blood-CSF-barrier (BCSFB) in choroid-plexus (CP) has long been hypothesized to be a main entry-point for intravenous-GBCAs into CSF. Most existing studies on this topic were performed in animals and human patient

Reviewing University Community Gardens for Sustainability : taking stock, comparisons with urban community gardens and mapping research opportunities

Community gardens (CGs) in university settings are faced with challenges associated with a transient and inexperienced population of student gardeners, but they also have the potential to have a lasting impact on the food behaviours of many young people. This paper undertakes a systematic critical review of literature about University Community Gardens for Sustainability (UCGS) in order to suggest

The internet-based intervention strategies for empowering activities in everyday life: A qualitative study of experiences of client with stroke.

BackgroundThere is a need to enhance access to and support for self-management of activities in everyday life after a stroke. Internet-based solutions have the potential to contribute to this development. Consequently, an internet-based intervention called Strategies for Empowering Activities in Everyday Life (SEE) was developed. The intervention aims to assist clients in developing management str

Swedish Dissertations and their Subjects, 1600–1820 : An Annotated Catalogue

This book challenges earlier understandings of early modern dissertations as unimaginative academic exercises. It argues for their continuous importance in scholarly and scientific discourse, and describes the richness and diversity of their subjects and themes. The book contains a complete catalogue of the almost 20,000 Swedish dissertations defended in Uppsala, Lund and Åbo, 1600 to 1820. The ca

Distributed synchronization of Euclidean transformations with guaranteed convergence

This paper addresses synchronization of Euclidean transformations over graphs. Synchronization in this context, unlike rendezvous or consensus, means that composite transformations over loops in the graph are equal to the identity. Given a set of non-synchronized transformations, the problem at hand is to find a set of synchronized transformations approximating well the non-synchronized transforma

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Statistical shape models based on point distribution models are powerful tools for image segmentation or shape analysis. The most challenging part in the generation of point distribution models is the identification of corresponding landmarks among all training shapes. Since in general the true correspondences are unknown, correspondences are frequently established under the hypothesis that correc

Optimal output consensus for linear systems : A topology free approach

In this paper, for any homogeneous system of agents with linear continuous time dynamics, we formulate an optimal control problem. In this problem a convex cost functional of the control signals of the agents shall be minimized, while the outputs of the agents shall coincide at some given finite time. This is an instance of the rendezvous or finite time consensus problem. We solve this problem wit

Moderate and stable pain reductions as a result of interdisciplinary pain rehabilitation—A cohort study from the Swedish quality registry for pain rehabilitation (SQRP)

Few studies have investigated the real-life outcomes of interdisciplinary multimodal pain rehabilitation programs (IMMRP) for chronic pain. This study has four aims: investigate effect sizes (ES); analyse correlation patterns of outcome changes; define a multivariate outcome measure; and investigate whether the clinical self-reported presentation pre-IMMRP predicts the multivariate outcome. To thi