Hypertension is considered the major modifiable risk factor for the development of cognitive impairment. Because increased blood pressure is often accompanied by an activation of the immune system, the concept of neuro-inflammation gained increasing attention in the field of hypertension-associated neurodegeneration. Particularly, hypertension-associated elevated circulating T-lymphocyte populatio

Great hopes have been placed in the sharing economy to provide a new business model based on peer-to-peer (P2P) exchanges of underutilized assets. As a model, the sharing economy has been expected to make significant contributions to sustainability, providing new opportunities for entrepreneurship, more sustainable use of resources, and consumer co-operation in tight economic networks. However, in

Aim: Perineal hemangiomas rarely occur in patients with anorectal malformations (ARMs), but they can pose a significant challenge and warrant special attention. Surgical incision of posterior sagittal anorectoplasty (PSARP) may involve the hemangioma site resulting in hemorrhage, damage to blood supply, leading to complications and adversely affecting outcome. The aim of this study was to review t

A growing body of research highlights how the Internet and social media offer new platforms for advocacy. This article contributes to the debates on digital advocacy by combining interest group and social media studies and present the notions of digital access politics, digital information politics, and digital protest politics for a comprehensive analysis of digital advocacy. Based on a netnograp

The acquisition of preverbal liaison (e.g. ils arrivent /ilzaʀiv/) in second language (L2) French has rarely been explored in detail in previous studies on obligatory liaison. In this study, we conducted an elicited imitation test in order to study the influence of proficiency level, modality (spoken or written), and verb frequency on the use of preverbal liaison among 42 Swedish learners of L2 Fr

Importance: It is uncertain to what extent established cardiovascular risk factors are associated with venous thromboembolism (VTE). Objective: To estimate the associations of major cardiovascular risk factors with VTE, ie, deep vein thrombosis and pulmonary embolism. Design, Setting, and Participants: This study included individual participant data mostly from essentially population-based cohort

The case for competition in health-care markets rests on economic models in which providers seek to maximize profits. However, little is known regarding how public health-care providers, who might not have a profit motive, react to increased competition from private providers. This study considers the heterogeneous effects of a primary health-care reform in a Swedish region that considerably loose

This introduction to the special issue presents a brief overview of the phonological phenomenon of liaison in French, drawing on the morphosyntactic contexts of its use by native speakers. We outline previous research on liaison in second language acquisition, focusing on the challenges this phenomenon presents to learner comprehension and production, and on major findings in each area. We then pr

This paper describes a frequency generator supporting over-an-octave tuning range for 5G receiver front-end. Generator is built by composition of smaller-range oscillators multiplexed to the common output that drives a downconversion mixer. Simulated in 28nm CMOS with full physical device models the composite oscillator exhibits a frequency tuning range from 21.5 to 60.7GHz (95.3%) dissipating les

The endothelin type B receptor (ETB or EDNRB) is highly plastic and is upregulated in smooth muscle cells (SMCs) by arterial injury and following organ culture in vitro. We hypothesized that this transcriptional plasticity may arise, in part, because EDNRB is controlled by a balance of transcriptional inputs from myocardin-related transcription factors (MRTFs) and ternary complex factors (TCFs). W

Results from previous research suggest that the ability to manage ambiguous problems during acute emergency and disaster management is a desirable quality among decision-makers. Ambiguity is a perception that arises when the problem-solver is dissatisfied with his or her understanding of the structure of the problem, and consequently of the problem-solving process. This article presents the result

JavaScript is a dynamically typed and object-based scripting language with runtime evaluation. It has emerged as an important language for client-side computation of web applications. Previous studies have shown differences in behavior between established JavaScript benchmarks and real-world web applications. However, there still remains several important aspects to explore. In this paper, we comp

Precis som för bilindustrin, investeras stora belopp på att skapa obemannade fartyg. De huvudsakliga fördelarna är att säkerheten förväntas förbättras, vinsternakommer att öka, samt att utsläppen kommer att minska. Helt autonoma fraktfartyg förväntas kunna korsa Atlanten helt obemannat innan år 2030, och fram tillsdess förväntas tekniken gradvis förbättra säkerheten och ersätta arbetsuppgiftersom As for the automotive industry, large efforts are being made by industry andacademia to create autonomous ships. Te solutions for this is very technologyintense, as many building blocks, often relying on AI technology, need to worktogether to create a complete system that is safe and reliable to use. Even whenthe ships are fully unmanned, humans are still foreseen to guide the ships whenunknown si

Atopic dermatitis (AD) is a clinically defined, highly pruritic, chronic inflammatory skin disease of children and adults. The diagnosis is made using evaluated clinical criteria. Disease activity is best measured with a composite score assessing both objective signs and subjective symptoms, such as SCORAD. The management of AD must consider the clinical and pathogenic variabilities of the disease

IMPORTANCE The extent to which large-caliber axonal degeneration contributes to Alzheimer disease (AD) progression is unknown. Cerebrospinal fluid (CSF) neurofilament light (NFL) concentration is a general marker of damage to large-calibermyelinated axons. OBJECTIVE To test whether CSF NFL concentration is associated with cognitive decline and imaging evidence of neurodegeneration and white matter