Filetype
Platelet-derived growth factor (PDGF) receptor signaling is a major functional determinant of cancer-associated fibroblasts (CAF). Elevated expression of PDGF receptors on stromal CAFs is associated with metastasis and poor prognosis, but mechanism(s) that underlie these connections are not understood. Here, we report the identification of the secreted glycoprotein stanniocalcin-1 (STC1) as a medi
Although it has been known for many years that long-term exposure of pancreatic islets to a high level of free fatty acids (FFA) or glucose negatively modulates islet hormone release, the identities of signals mediating these effects are not yet fully clarified. The overall objective of this study was to investigate signal transduction pathways involved in FFA- and glucose-exerted effects on beta-
Distributions sensitive to the underlying event in QCD jet events have been measured with the ATLAS detector at the LHC, based on of proton-proton collision data collected at a centre-of-mass energy of 7 . Charged-particle mean and densities of all-particle and charged-particle multiplicity and have been measured in regions azimuthally transverse to the hardest jet in each event. These are present
Double-differential three-jet production cross-sections are measured in proton-proton collisions at a centre-of-mass energy of [Formula: see text] using the ATLAS detector at the large hadron collider. The measurements are presented as a function of the three-jet mass [Formula: see text], in bins of the sum of the absolute rapidity separations between the three leading jets [Formula: see text]. In
Five recent techniques from hybrid and optimal control are evaluated on two power electronics benchmark problems. The benchmarks involve a number of practically interesting operating scenarios for fixed-frequency synchronous dc-dc converters. The specifications are defined such that good performance can only be obtained if the switched and nonlinear nature of the problem is accounted for during th
This paper focuses on the issue plasticity within the framework of a micromechanical model for single-crystal shape-memory alloys. As a first step towards a complete micromechanical formulation of such models, we work with classical J(2)-von Mises-type plasticity for simplicity. The modeling of martensitic phase transitions is based on the concept of energy relaxation (quasiconvexification) in con
In this paper public participation in Swedish municipal traffic planning is studied with the focus onto what extent and how municipalities and consultants interact with participants in traffic-planning processes. Telephone interviews with planners were performed and planners' insight and knowledge of participation methods are analysed in order to give an indication of which prerequisites seem to d
Popular Abstract in Swedish Livmoderhalscancer är den näst vanligaste cancern för kvinnor i världen, över 500 000 kvinnor insjuknar varje år. Varje år dör dessutom 275 000 kvinnor av denna sjukdom. De flesta av de som insjuknar och dör bor i utvecklingsländer. I Sverige drabbas ca 400 kvinnor varje år. På sextiotalet i Sverige började vi screena för denna cancertyp i Sverige. Detta genom hälsokonCervical cancer is the fourth most common reason for cancer death amongst women worldwide, with 500 000 new cases every year. Most of these women live in developing countries. Cervical screening programs can reduce the incidence by 50%, but are not common in the developing world. In Sweden there are approximately 400 new cases of cervical cancer yearly, despite the existence of a screening program
Effective dopamine (DA) neuron differentiation from neural precursor cells (NPCs) is prerequisite for precursor/stem cell-based therapy of Parkinson's disease (PD). Nurr1, an orphan nuclear receptor, has been reported as a transcription factor that can drive DA neuron differentiation from non-dopaminergic NPCs in vitro. However, Nurr1 alone neither induces full neuronal maturation nor expression o
In this paper we describe the find of an early Mesolithic skeleton from Österöd, Bro parish, in central Bohuslän. The skeleton was originally found in 1903 by diggers in a shell bank, but was only recovered in 1933 by Johan Alin. In 2007, 14C analysis of a tooth produced the date 9025±65 BP uncalibrated, making the skeleton one of the oldest known from Scandinavia. Osteological determinations show
Finanskrisen 2008 har väckt starkt intresse för kreditvolymens och skuldsättningens roll i samhällsekonomin. Här kartlägger vi framväxten av en svensk kreditcykel. Den har längre varaktighet och större svängningar än den traditionella konjunkturcykeln samt en nära koppling till den internationella kreditcykeln. Långvarig och hög tillväxt i kreditvolymen i förhållande till den reala tillväxten lede
Conclusion: This study shows a persistent trend of an increase in the incidence of carcinoma of the tongue into the twenty-first century for both sexes and all age groups except for young males. Objectives: During the last decades increased incidence of squamous cell carcinoma (SCC) of the tongue in young adults has been reported. We previously showed an increased incidence in SCC of the tongue in
Energifrågan berör många politikområden, inte minst säkerhetspolitiken. Föreställningar om framtida energisäkerhet, eller energi och säkerhet, baseras oundvikligen på underliggande antaganden och subjektiva perspektiv som gärna färgas av dagsaktuella problem. Detta kan innebära problem för dem som ägnar sig åt beslutsfattande i ett långsiktigt perspektiv. Denna rapport har ett säkerhetspolitiskt
The g factors of the first excited 2(+) states in the Sn-112,Sn-114,Sn-116,Sn-122,Sn-124 isotopes have been measured with high accuracy using the transient field technique in combination with Coulomb excitation in inverse kinematics. The experimental results are discussed in a qualitative way on the basis of empirical single-particle g factors of the relevant proton and neutron orbitals and are co
